MAD2 mitotic arrest deficient-like 2 (yeast)

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Synonym

MAD2 mitotic arrest deficient-like 2 (yeast), MAD2L2, hREV7, MAD2-like 2, REV7, Mitotic spindle assembly checkpoint protein MAD2B, MAD2B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:17.60 artery/aorta:- vein:66.60 lymphnode:10.10 peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:80.70 bone:12.80 skin:9.60
GeneChip nodata
CAGE cerebrum:2.59 cerebellum:- brain stem:2.57 corpus callosum/glia:2.81 pineal gland:1.98 peripheral nerve:- spine:2.67 retina:- eye:- artery/aorta:2.48 vein:2.80 lymphnode:2.68 peripheral blood:- spleen:2.48 thymus:3.62 bone marrow:- adipose:2.45 bone:- skin:-
RNA-seq cerebrum:0.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:18.20 prostate:33.80 ovary:- testis:34.60 heart:38.30 muscle:40.20 esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:10.60        lung:34.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:46.50 salivary:-
GeneChip nodata
CAGE uterus:2.29 placenta:2.18 prostate:2.61 ovary:2.77 testis:3.77 heart:2.76 muscle:2.75 esophagus:2.44 stomach:- intestine:2.10 colon:2.42     liver/hepato:3.44    lung:2.63 bladder:2.47 kidney:2.41 pituitary:2.15 thyroid/parathyroid:2.49 adrenal gland:- pancreas:3.02 breast:2.74 salivary:2.60
RNA-seq uterus:- placenta:- prostate:0.09 ovary:0.31 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.45 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001127325
Gene ID 10459
Unigene ID Hs.19400
Probe set ID -
Ensembl ID ENSG00000116670
GTEx ID ENSG00000116670

Orthologous Gene

Mouse[1]  NM_027985
Rat[1]  NM_001012106

Chromosomal Region

1p36.22  [11,734,538  -  11,751,707]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10366450
10527948
10660610
11277934
11459825
11459826
11485998
11717438
12477932
12529368
12951035
14667819
14702039
15189446
15380106
15489334
15988022
16618761
16710414
17044027
17268814
17296730
17333263
17541814
17719540
18624398
19060904
19443654
19753112
20054135
20164194
20360068
20554254
21139048
21143968
21152103
21690293
21890473
21906983
21926160
22303021
22505724
22589738
22660985
22828282
22859296
22869133
23000965
23007861
23287467
24100295
24597627

Gene Ontology  (GO ID)

Biological Process

GO:0007015  actin filament organization
GO:0051301  cell division
GO:0042772  DNA damage response, signal transduction resulting in transcription
GO:0006281  DNA repair
GO:0006302  double-strand break repair
GO:0007067  mitosis
GO:0007094  mitotic cell cycle spindle assembly checkpoint
GO:0060564  negative regulation of anaphase-promoting complex activity during mitotic cell cycle
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0042177  negative regulation of protein catabolic process
GO:0010944  negative regulation of transcription by competitive promoter binding
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0001558  regulation of cell growth
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005680  anaphase-promoting complex
GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005819  spindle
GO:0016035  zeta DNA polymerase complex

Molecular Function

GO:0008432  JUN kinase binding
GO:0005515  protein binding