sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

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Synonym

Semaphorin-3C precursor, SEMA3C, SEMAE, Sema E, Semaphorin E, SemE

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:75.80 cerebellum:12.60 brain stem:- corpus callosum/glia:116.60 pineal gland:- peripheral nerve:122.70 spine:336.90 retina:118.60 eye:47 artery/aorta:60 vein:66.60 lymphnode:- peripheral blood:- spleen:56.70 thymus:- bone marrow:59 adipose:- bone:255.90 skin:52.80
GeneChip cerebrum:5.18 cerebellum:4.03 brain stem:6.23 corpus callosum/glia:5.90 pineal gland:- peripheral nerve:6.80 spine:5.91 retina:- eye:- artery/aorta:6.93 vein:7.43 lymphnode:3.71 peripheral blood:- spleen:6.38 thymus:3.87 bone marrow:3.68 adipose:8.13 bone:- skin:7.12
CAGE cerebrum:2.65 cerebellum:- brain stem:4.20 corpus callosum/glia:3.39 pineal gland:2.72 peripheral nerve:- spine:3.24 retina:- eye:- artery/aorta:4.30 vein:3.89 lymphnode:1.55 peripheral blood:- spleen:3.39 thymus:1.10 bone marrow:- adipose:4.57 bone:- skin:-
RNA-seq cerebrum:2.86 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.17 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.31 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:18.20 prostate:146.40 ovary:- testis:86.50 heart:38.30 muscle:- esophagus:- stomach:- intestine:97.20 colon:101.80     liver/hepato:31.70        lung:127.10    bladder:- kidney:52 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:176.60 salivary:-
GeneChip uterus:8.25 placenta:4.74 prostate:8.96 ovary:7.78 testis:6.20 heart:7.19 muscle:7.33 esophagus:5.39 stomach:7.12 intestine:6.80 colon:6.06 liver/hepato:3.66 lung:6.54 bladder:- kidney:4.92 pituitary:4.14 thyroid/parathyroid:4.48 adrenal gland:5.49 pancreas:3.57 breast:7.90 salivary:6.31
CAGE uterus:4.78 placenta:3.04 prostate:4.44 ovary:4.32 testis:3.78 heart:4.09 muscle:2.65 esophagus:4.24 stomach:- intestine:3.62 colon:4.22     liver/hepato:0.78    lung:3.77 bladder:4.83 kidney:3.05 pituitary:2.46 thyroid/parathyroid:1.64 adrenal gland:- pancreas:1.42 breast:4.07 salivary:4.01
RNA-seq uterus:- placenta:- prostate:5.06 ovary:4.10 testis:4.15 heart:3.36 muscle:1.79 esophagus:- stomach:- intestine:- colon:5.44     liver/hepato:0.25        lung:4.70    bladder:- kidney:2.72 pituitary:- thyroid/parathyroid:2.84 adrenal gland:1.26 pancreas:- breast:6.40 salivary:-

Gene Information

IDs

Refseq ID NM_006379
Gene ID 10512
Unigene ID Hs.269109
Probe set ID 203789_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000075223
GTEx ID ENSG00000075223

Orthologous Gene

Mouse[1]  NM_013657
Rat[1]  NM_001106578

Chromosomal Region

7q21.11  [80,371,854  -  80,551,675]

Gene Family (Interpro ID)

IPR003659  Plexin/semaphorin/integrin
IPR001627  Semaphorin/CD100 antigen
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

7748561
7829101
8889548
9168980
9331348
9405678
12174914
12477932
12690205
12730958
12853948
15077297
15146197
15489334
15609325
17390026
19414484
19666519
19915008
22899844
22924992
23666167

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0001974  blood vessel remodeling
GO:0003215  cardiac right ventricle morphogenesis
GO:0060666  dichotomous subdivision of terminal units involved in salivary gland branching
GO:0006955  immune response
GO:0060174  limb bud formation
GO:0001755  neural crest cell migration
GO:0021915  neural tube development
GO:0003151  outflow tract morphogenesis
GO:0009791  post-embryonic development
GO:0003350  pulmonary myocardium development
GO:0042493  response to drug
GO:0001756  somitogenesis

Cellular Component

GO:0005615  extracellular space
GO:0016020  membrane

Molecular Function

GO:0004872  receptor activity
GO:0030215  semaphorin receptor binding