sorbin and SH3 domain containing 1

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Synonym

SH3P12, DKFZp586P1422, sh3p12, SORBS1, SORB1, ponsin, SH3-domain protein 5 (ponsin), SH3 domain protein 5, DKFZp451C066, R85FL, c-Cbl-associated protein, Sorbin and SH3 domain-containing protein 1, KIAA1296, Ponsin, FLJ12406, SH3D5, sorbin and SH3 domain containing 1, FLAF2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.27 cerebellum:8.08 brain stem:7.71 corpus callosum/glia:8.88 pineal gland:- peripheral nerve:9.58 spine:9.66 retina:- eye:- artery/aorta:9.68 vein:10.16 lymphnode:4.52 peripheral blood:- spleen:4.87 thymus:3.85 bone marrow:4.48 adipose:9.63 bone:- skin:7.88
CAGE cerebrum:4.92 cerebellum:- brain stem:4.65 corpus callosum/glia:5.30 pineal gland:4.14 peripheral nerve:- spine:5.50 retina:- eye:- artery/aorta:6.47 vein:4.51 lymphnode:2.83 peripheral blood:- spleen:2.51 thymus:0.50 bone marrow:- adipose:5.91 bone:- skin:-
RNA-seq cerebrum:2.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.36 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:8.22 placenta:7.66 prostate:9.31 ovary:6.57 testis:5.17 heart:9.93 muscle:9.71 esophagus:7.23 stomach:9 intestine:8.56 colon:8.49 liver/hepato:7.32 lung:6.52 bladder:- kidney:5.84 pituitary:4.77 thyroid/parathyroid:5.35 adrenal gland:6.47 pancreas:5.12 breast:8.77 salivary:6.65
CAGE uterus:5.26 placenta:4.31 prostate:5.78 ovary:4.67 testis:3.84 heart:5.81 muscle:5.84 esophagus:5.76 stomach:- intestine:4.33 colon:5.31     liver/hepato:4.37    lung:4.08 bladder:6.42 kidney:3.63 pituitary:3.26 thyroid/parathyroid:3.41 adrenal gland:- pancreas:3.20 breast:5.48 salivary:3.72
RNA-seq uterus:- placenta:- prostate:0.85 ovary:0.09 testis:1.11 heart:2.94 muscle:2.99 esophagus:- stomach:- intestine:- colon:0.57     liver/hepato:0.00        lung:0.90    bladder:- kidney:0.15 pituitary:- thyroid/parathyroid:2.21 adrenal gland:0.89 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_024991
Gene ID 10580
Unigene ID -
Probe set ID 218087_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000095637
GTEx ID ENSG00000095637

Orthologous Gene

Mouse[45]  NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362
Rat[45]  NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362

Chromosomal Region

10q24.1  [97,071,528  -  97,321,171]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

9447983
9461600
10085297
10583506
10718198
11001060
11076863
11230166
11371513
11374898
11481476
11532984
11557983
11997497
12079283
12395215
12421765
12477932
12504111
12510380
12650714
12690089
12765336
12849814
14627618
14702039
15031295
15128873
15489334
15489336
15716063
15777793
15939299
16374509
16381901
16385451
17082770
17353931
17462669
17548467
18029348
18394047
18660489
19165527
19282865
19891780
20129698
20201926
20379614
20936779
21041247
21988832
22094256
22235335
22745667
23251661
23382691
23793025
23892081
24255178

Gene Ontology  (GO ID)

Biological Process

GO:0007160  cell-matrix adhesion
GO:0032869  cellular response to insulin stimulus
GO:0048041  focal adhesion formation
GO:0015758  glucose transport
GO:0008286  insulin receptor signaling pathway
GO:0006936  muscle contraction
GO:0090004  positive regulation of establishment of protein localization in plasma membrane
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0046889  positive regulation of lipid biosynthetic process
GO:0043149  stress fiber formation

Cellular Component

GO:0005913  cell-cell adherens junction
GO:0005924  cell-substrate adherens junction
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005925  focal adhesion
GO:0005899  insulin receptor complex
GO:0045121  membrane raft
GO:0016363  nuclear matrix
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0001725  stress fiber
GO:0005915  zonula adherens

Molecular Function

GO:0003779  actin binding
GO:0008092  cytoskeletal protein binding
GO:0005158  insulin receptor binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0005070  SH3/SH2 adaptor activity