adenylate cyclase 2 (brain)

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Synonym

KIAA1060, ADCY2, ATP pyrophosphate-lyase 2, FLJ16822, Adenylyl cyclase 2, adenylate cyclase 2 (brain), Adenylate cyclase type 2, Adenylate cyclase type II, HBAC2, FLJ45092, MGC133314

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:116.10 cerebellum:- brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:224.60 retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:- thymus:- bone marrow:- adipose:161.30 bone:64 skin:28.80
GeneChip cerebrum:4.96 cerebellum:4.88 brain stem:4.91 corpus callosum/glia:4.81 pineal gland:- peripheral nerve:4.65 spine:5.28 retina:- eye:- artery/aorta:4.94 vein:4.97 lymphnode:4.57 peripheral blood:- spleen:4.57 thymus:4.56 bone marrow:4.98 adipose:4.82 bone:- skin:4.97
CAGE cerebrum:3.99 cerebellum:- brain stem:3.66 corpus callosum/glia:4.21 pineal gland:4.17 peripheral nerve:- spine:4.67 retina:- eye:- artery/aorta:2.34 vein:1.29 lymphnode:0.65 peripheral blood:- spleen:0 thymus:0.12 bone marrow:- adipose:1.44 bone:- skin:-
RNA-seq cerebrum:4.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.43 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:- prostate:56.30 ovary:- testis:60.60 heart:12.80 muscle:100.50 esophagus:- stomach:21.20 intestine:- colon:8.50     liver/hepato:21.10        lung:34.20    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:4.75 placenta:4.68 prostate:4.91 ovary:4.61 testis:4.88 heart:4.65 muscle:5.53 esophagus:4.71 stomach:4.69 intestine:5.11 colon:4.75 liver/hepato:4.76 lung:4.59 bladder:- kidney:4.65 pituitary:5.16 thyroid/parathyroid:4.59 adrenal gland:4.58 pancreas:5.11 breast:4.58 salivary:4.63
CAGE uterus:2.06 placenta:0.81 prostate:2.17 ovary:1.82 testis:2.19 heart:0.65 muscle:3.69 esophagus:1.64 stomach:- intestine:1.53 colon:1.89     liver/hepato:0.14    lung:0.42 bladder:1.58 kidney:0.71 pituitary:2.74 thyroid/parathyroid:0.67 adrenal gland:- pancreas:0 breast:1.16 salivary:1.15
RNA-seq uterus:- placenta:- prostate:1.27 ovary:1.21 testis:1.67 heart:0.11 muscle:4.64 esophagus:- stomach:- intestine:- colon:1.47     liver/hepato:0        lung:0.44    bladder:- kidney:0.20 pituitary:- thyroid/parathyroid:2.71 adrenal gland:0.43 pancreas:- breast:0.89 salivary:-

Gene Information

IDs

Refseq ID NM_020546
Gene ID 108
Unigene ID Hs.481545
Probe set ID 217687_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000078295
GTEx ID ENSG00000078295

Orthologous Gene

Mouse[1]  NM_153534
Rat [0]  

Chromosomal Region

5p15.31  [7,396,321  -  7,830,194]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1427768
2165385
7937899
7959689
8619474
8663304
8692867
9110174
9268375
9417641
10089566
10470851
10807185
10808179
11299302
11549699
11884542
12477932
12503609
12626323
14702039
14993377
15489334
16344560
18519826
19156168
20379614
20664520
21228062
21528083
21890473
22461431
22505724
22589738
22864933
23504261
23889134

Gene Ontology  (GO ID)

Biological Process

GO:0007189  activation of adenylate cyclase activity by G-protein signaling pathway
GO:0007202  activation of phospholipase C activity
GO:0034199  activation of protein kinase A activity
GO:0006171  cAMP biosynthetic process
GO:0071377  cellular response to glucagon stimulus
GO:0006112  energy reserve metabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0007193  inhibition of adenylate cyclase activity by G-protein signaling pathway
GO:0045087  innate immune response
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007165  signal transduction
GO:0007268  synaptic transmission
GO:0055085  transmembrane transport
GO:0006833  water transport

Cellular Component

GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0005622  intracellular
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005886  plasma membrane
GO:0043234  protein complex

Molecular Function

GO:0004016  adenylate cyclase activity
GO:0008179  adenylate cyclase binding
GO:0005524  ATP binding
GO:0008294  calcium- and calmodulin-responsive adenylate cyclase activity
GO:0031683  G-protein beta/gamma-subunit binding
GO:0046872  metal ion binding
GO:0046982  protein heterodimerization activity