leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

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Synonym

LILRB1, CD85j antigen, ILT-2, ILT2, LIR1, MIR-7, MIR7, Immunoglobulin-like transcript 2, Leukocyte immunoglobulin-like receptor 1, Monocyte/macrophage immunoglobulin-like receptor 7, CD85j, LIR-1, CD85, CD85J

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.69 cerebellum:5.72 brain stem:5.78 corpus callosum/glia:6 pineal gland:- peripheral nerve:5.43 spine:5.85 retina:- eye:- artery/aorta:5.79 vein:5.85 lymphnode:6.21 peripheral blood:- spleen:6.56 thymus:5.64 bone marrow:6.66 adipose:5.78 bone:- skin:5.93
CAGE cerebrum:1.24 cerebellum:- brain stem:2.03 corpus callosum/glia:2.15 pineal gland:0.82 peripheral nerve:- spine:2.34 retina:- eye:- artery/aorta:1.72 vein:2.25 lymphnode:2.89 peripheral blood:- spleen:4.36 thymus:1.01 bone marrow:- adipose:1.60 bone:- skin:-
RNA-seq cerebrum:0.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.72 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.72 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.40 placenta:5.58 prostate:5.35 ovary:5.63 testis:5.24 heart:5.79 muscle:5.80 esophagus:5.34 stomach:5.59 intestine:5.89 colon:5.83 liver/hepato:5.88 lung:6.27 bladder:- kidney:5.50 pituitary:5.55 thyroid/parathyroid:5.29 adrenal gland:5.62 pancreas:5.96 breast:5.38 salivary:5.66
CAGE uterus:0.89 placenta:1.90 prostate:1.58 ovary:1.16 testis:0.57 heart:1.17 muscle:0.42 esophagus:1.08 stomach:- intestine:1.24 colon:1.53     liver/hepato:1.81    lung:2.21 bladder:1.15 kidney:1.06 pituitary:0.86 thyroid/parathyroid:0.49 adrenal gland:- pancreas:0.94 breast:1.36 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0.72 ovary:0.00 testis:0.56 heart:0.02 muscle:0.05 esophagus:- stomach:- intestine:- colon:0.32     liver/hepato:0.54        lung:0.63    bladder:- kidney:0.21 pituitary:- thyroid/parathyroid:0.12 adrenal gland:2.37 pancreas:- breast:0.40 salivary:-

Gene Information

IDs

Refseq ID NM_001081637
Gene ID 10859
Unigene ID -
Probe set ID 207104_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000104972
GTEx ID ENSG00000104972

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

19q13.42  [55,085,346  -  55,148,979]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8125298
8258145
9079806
9259559
9285411
9382880
9548455
9842885
9933109
10591185
10941837
11114384
11169396
11491530
11751964
11907092
12130517
12390682
12477932
12847262
12853576
12874224
12897781
14662864
14702039
15100307
15304001
15474475
15489334
15585844
15670976
15905516
16014635
16210603
16305801
16344560
16455647
17056715
17400057
17567994
17601702
17869268
17998301
18094328
18398485
18538388
18550825
18632577
18684926
18802077
18821690
18946352
19124746
19136885
19304799
19658091
19841038
19913121
20139023
20194892
20580616
20600445
20628086
20631139
21092455
21213105
21233315
21242521
21270408
21551166
21559424
21817101
22028331
22242197
22296096
22574131
22623953
22844324
22965785
23103378
23208495
23228398
23348966
23404538
23415844
23476104
23514593
23552990
23666960
23685425
23756160
23955630
23997222
24156302
24453251
24550301

Gene Ontology  (GO ID)

Biological Process

GO:0071222  cellular response to lipopolysaccharide
GO:0051607  defense response to virus
GO:0002774  Fc receptor mediated inhibitory signaling pathway
GO:0002767  immune response-inhibiting cell surface receptor signaling pathway
GO:0032609  interferon-gamma production
GO:0046636  negative regulation of alpha-beta T cell activation
GO:0051926  negative regulation of calcium ion transport
GO:0045786  negative regulation of cell cycle
GO:0002740  negative regulation of cytokine secretion during immune response
GO:0045806  negative regulation of endocytosis
GO:0045077  negative regulation of interferon-gamma biosynthetic process
GO:0032689  negative regulation of interferon-gamma production
GO:0032945  negative regulation of mononuclear cell proliferation
GO:0045953  negative regulation of natural killer cell mediated cytotoxicity
GO:0014063  negative regulation of serotonin secretion
GO:0001915  negative regulation of T cell mediated cytotoxicity
GO:0042130  negative regulation of T cell proliferation
GO:0042536  negative regulation of tumor necrosis factor biosynthetic process
GO:0043065  positive regulation of apoptosis
GO:0045919  positive regulation of cytolysis
GO:0002230  positive regulation of defense response to virus by host
GO:0010628  positive regulation of gene expression
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0031623  receptor internalization
GO:0050776  regulation of immune response
GO:0009615  response to virus
GO:0007165  signal transduction
GO:0002309  T cell proliferation during immune response

Cellular Component

GO:0005737  cytoplasm
GO:0009897  external side of plasma membrane
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0030107  HLA-A specific inhibitory MHC class I receptor activity
GO:0030109  HLA-B specific inhibitory MHC class I receptor activity
GO:0042288  MHC class I protein binding
GO:0032393  MHC class I receptor activity
GO:0042803  protein homodimerization activity
GO:0008157  protein phosphatase 1 binding
GO:0042169  SH2 domain binding