ADAM metallopeptidase domain 28

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Synonym

A disintegrin and metalloproteinase domain 28, eMDCII, MDC-Ls, ADAM 28 precursor, ADAM23, a disintegrin and metalloproteinase domain 28, ADAM28, eMDC II, MDC-Lm, MDCL, ADAM metallopeptidase domain 28, MDC-L

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:101.10 peripheral blood:18.20 spleen:37.80 thymus:51.50 bone marrow:59 adipose:- bone:25.60 skin:43.20
GeneChip cerebrum:6.22 cerebellum:6.11 brain stem:6.26 corpus callosum/glia:6.45 pineal gland:- peripheral nerve:6.15 spine:6.35 retina:- eye:- artery/aorta:6.43 vein:6.48 lymphnode:6.79 peripheral blood:- spleen:6.76 thymus:6.22 bone marrow:6.49 adipose:6.29 bone:- skin:6.11
CAGE cerebrum:2.81 cerebellum:- brain stem:3.63 corpus callosum/glia:3.69 pineal gland:2.78 peripheral nerve:- spine:4.22 retina:- eye:- artery/aorta:2.73 vein:3.41 lymphnode:3.84 peripheral blood:- spleen:3.66 thymus:1.60 bone marrow:- adipose:1.88 bone:- skin:-
RNA-seq cerebrum:0.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.92 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.60 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:- prostate:- ovary:372.60 testis:13 heart:- muscle:- esophagus:- stomach:233.70 intestine:- colon:17     liver/hepato:-        lung:34.20    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.18 placenta:5.88 prostate:5.92 ovary:6.16 testis:5.70 heart:6.10 muscle:6.22 esophagus:6.17 stomach:6.79 intestine:6.28 colon:6.70 liver/hepato:5.97 lung:6.04 bladder:- kidney:6.10 pituitary:6.40 thyroid/parathyroid:5.97 adrenal gland:6.19 pancreas:6.38 breast:5.92 salivary:6.17
CAGE uterus:2.39 placenta:1.11 prostate:2.13 ovary:2.13 testis:1.57 heart:0.97 muscle:0.84 esophagus:1.92 stomach:- intestine:2.71 colon:2.83     liver/hepato:1.07    lung:2.44 bladder:3.13 kidney:2.14 pituitary:3.87 thyroid/parathyroid:0.64 adrenal gland:- pancreas:1.74 breast:1.36 salivary:2.78
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.46 testis:1.11 heart:0.09 muscle:0.04 esophagus:- stomach:- intestine:- colon:0.38     liver/hepato:0.15        lung:0.14    bladder:- kidney:0.12 pituitary:- thyroid/parathyroid:0.26 adrenal gland:3.30 pancreas:- breast:0.31 salivary:-

Gene Information

IDs

Refseq ID NM_021777
Gene ID 10863
Unigene ID Hs.174030
Probe set ID 208269_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000042980
GTEx ID ENSG00000042980

Orthologous Gene

Mouse[10]  NM_001048175, NM_010082, NM_183366
Rat [0]  

Chromosomal Region

8p21.2  [24,151,553  -  24,216,531]

Gene Family (Interpro ID)

IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

8125298
10506182
10587367
10794709
11724793
12477932
12667064
12777399
15013428
16052521
17047053
17597069
18690470
19054571
19527685
19896699
20112342
20450360
20544843
20881960
20971063
21077327
21329817
21698479
21782798
21913264
22636800
23010875
23527725
23640157
23643150
24007880
24613731

Gene Ontology  (GO ID)

Biological Process

GO:0006508  proteolysis
GO:0007283  spermatogenesis

Cellular Component

GO:0005576  extracellular region
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0008270  zinc ion binding