ADAM metallopeptidase with thrombospondin type 1 motif, 6

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Synonym

ADAMTS-6 precursor, ADAMTS6, ADAM-TS 6, ADAM-TS6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:35.30 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:18.90 thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:3.96 cerebellum:4.12 brain stem:3.96 corpus callosum/glia:4 pineal gland:- peripheral nerve:4.09 spine:3.99 retina:- eye:- artery/aorta:4.19 vein:4.45 lymphnode:3.89 peripheral blood:- spleen:4.01 thymus:3.92 bone marrow:4.10 adipose:4.07 bone:- skin:3.97
CAGE cerebrum:0.64 cerebellum:- brain stem:0.41 corpus callosum/glia:0.79 pineal gland:0.56 peripheral nerve:- spine:1.30 retina:- eye:- artery/aorta:2.19 vein:0.70 lymphnode:1.27 peripheral blood:- spleen:1.65 thymus:1.46 bone marrow:- adipose:0.63 bone:- skin:-
RNA-seq cerebrum:0.09 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:87.40 prostate:- ovary:- testis:13 heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:84.80     liver/hepato:10.60        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.11 placenta:5.81 prostate:3.78 ovary:3.92 testis:4.01 heart:3.90 muscle:4.21 esophagus:3.91 stomach:3.92 intestine:3.97 colon:4.16 liver/hepato:3.91 lung:3.92 bladder:- kidney:3.85 pituitary:4.11 thyroid/parathyroid:4.02 adrenal gland:4.01 pancreas:4.34 breast:3.91 salivary:3.88
CAGE uterus:1.76 placenta:3.54 prostate:1.44 ovary:1.18 testis:1.11 heart:1.21 muscle:0.17 esophagus:0.94 stomach:- intestine:0.93 colon:1.14     liver/hepato:0.46    lung:0.80 bladder:1.49 kidney:1.09 pituitary:1.18 thyroid/parathyroid:0.28 adrenal gland:- pancreas:0.58 breast:1.16 salivary:0
RNA-seq uterus:- placenta:- prostate:0.86 ovary:0.21 testis:0.62 heart:0.13 muscle:0.06 esophagus:- stomach:- intestine:- colon:0.12     liver/hepato:0.02        lung:0.11    bladder:- kidney:0.16 pituitary:- thyroid/parathyroid:0.12 adrenal gland:0.43 pancreas:- breast:0.14 salivary:-

Gene Information

IDs

Refseq ID NM_197941
Gene ID 11174
Unigene ID Hs.482291
Probe set ID 220866_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000049192
GTEx ID ENSG00000049192

Orthologous Gene

Mouse[1]  NM_001081020
Rat[1]  NM_001081020

Chromosomal Region

5q12.3  [64,444,563  -  64,777,747]

Gene Family (Interpro ID)

IPR000884  Thrombospondin, type 1 repeat

Link to Pubmed  (Pubmed ID)

7566098
8401585
10464288
11167130
12477932
15123239
16129570
18579725
20379614
20889312
23212062
23291589
23727862
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006508  proteolysis

Cellular Component

GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0008270  zinc ion binding