interleukin-1 receptor-associated kinase 3

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Synonym

IRAK-3, interleukin-1 receptor-associated kinase 3, IRAK-M, Interleukin-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M, IRAK3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:118.60 eye:23.50 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:36.40 spleen:18.90 thymus:12.90 bone marrow:177.10 adipose:80.70 bone:25.60 skin:28.80
GeneChip cerebrum:3.70 cerebellum:3.61 brain stem:3.73 corpus callosum/glia:3.59 pineal gland:- peripheral nerve:3.57 spine:3.54 retina:- eye:- artery/aorta:4.22 vein:4.10 lymphnode:3.83 peripheral blood:- spleen:4.24 thymus:3.46 bone marrow:6.03 adipose:4.23 bone:- skin:4.14
CAGE cerebrum:2.06 cerebellum:- brain stem:2.39 corpus callosum/glia:2.08 pineal gland:2.34 peripheral nerve:- spine:3.01 retina:- eye:- artery/aorta:3.44 vein:2.95 lymphnode:3.36 peripheral blood:- spleen:3.99 thymus:1.44 bone marrow:- adipose:4.00 bone:- skin:-
RNA-seq cerebrum:1.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.24 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.75 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:123.90 prostate:- ovary:- testis:21.60 heart:25.50 muscle:- esophagus:- stomach:786 intestine:- colon:17     liver/hepato:-        lung:24.40    bladder:- kidney:20.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.72 placenta:3.63 prostate:3.72 ovary:3.85 testis:3.52 heart:4.14 muscle:3.66 esophagus:3.71 stomach:4.02 intestine:3.66 colon:3.78 liver/hepato:3.78 lung:4.50 bladder:- kidney:3.64 pituitary:3.91 thyroid/parathyroid:3.56 adrenal gland:4 pancreas:3.42 breast:3.78 salivary:3.83
CAGE uterus:2.93 placenta:2.35 prostate:2.99 ovary:2.79 testis:2.59 heart:3.55 muscle:2.60 esophagus:2.63 stomach:- intestine:2.27 colon:2.78     liver/hepato:1.86    lung:3.90 bladder:3.21 kidney:2.32 pituitary:3.88 thyroid/parathyroid:2.35 adrenal gland:- pancreas:1.74 breast:3.58 salivary:1.67
RNA-seq uterus:- placenta:- prostate:0.22 ovary:0.86 testis:0.88 heart:2.13 muscle:0.48 esophagus:- stomach:- intestine:- colon:2.01     liver/hepato:1.10        lung:2.37    bladder:- kidney:0.25 pituitary:- thyroid/parathyroid:1.62 adrenal gland:2.46 pancreas:- breast:1.19 salivary:-

Gene Information

IDs

Refseq ID NM_007199
Gene ID 11213
Unigene ID Hs.369265
Probe set ID 220034_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000090376
GTEx ID ENSG00000090376

Orthologous Gene

Mouse[1]  NM_028679
Rat[1]  NM_001108101

Chromosomal Region

12q14.3  [66,582,659  -  66,648,402]

Gene Family (Interpro ID)

IPR000488  Death
IPR011029  DEATH-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10383454
12054681
12138165
12150927
12477932
12721283
14592437
14702039
15342556
15489334
15728517
16344560
16432636
16437636
17379480
17503328
17558906
17982103
18156187
18354163
18987746
19013233
19114913
19166926
19264973
19372141
19414798
19423540
19453261
19561104
19913121
20237496
20331378
20406964
20438785
20448286
20628086
21098228
21278795
21297081
21890473
21903422
21987497
21988832
22070913
22154382
22272346
22634523
22886503
22939624
23376919
23588345
24074582

Gene Ontology  (GO ID)

Biological Process

GO:0019221  cytokine-mediated signaling pathway
GO:0070498  interleukin-1-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0001960  negative regulation of cytokine-mediated signaling pathway
GO:0045824  negative regulation of innate immune response
GO:0032695  negative regulation of interleukin-12 production
GO:0032715  negative regulation of interleukin-6 production
GO:0010936  negative regulation of macrophage cytokine production
GO:0043407  negative regulation of MAP kinase activity
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0042177  negative regulation of protein catabolic process
GO:0043242  negative regulation of protein complex disassembly
GO:0034122  negative regulation of toll-like receptor signaling pathway
GO:0032720  negative regulation of tumor necrosis factor production
GO:0010933  positive regulation of macrophage tolerance induction
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0043244  regulation of protein complex disassembly
GO:0043330  response to exogenous dsRNA
GO:0070555  response to interleukin-1
GO:0032496  response to lipopolysaccharide
GO:0032494  response to peptidoglycan
GO:0009615  response to virus

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004674  protein serine/threonine kinase activity