serine/threonine kinase 38

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Synonym

NDR1, serine/threonine kinase 38, Nuclear Dbf2-related kinase 1, NDR1 protein kinase, Serine/threonine-protein kinase 38, STK38, NDR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:48.60 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:122.70 spine:- retina:118.60 eye:29.40 artery/aorta:119.90 vein:- lymphnode:91 peripheral blood:72.90 spleen:94.50 thymus:128.80 bone marrow:452.60 adipose:80.70 bone:64 skin:72
GeneChip cerebrum:6.02 cerebellum:6.30 brain stem:5.95 corpus callosum/glia:6.34 pineal gland:- peripheral nerve:7.51 spine:6.13 retina:- eye:- artery/aorta:7.43 vein:7.22 lymphnode:8.04 peripheral blood:- spleen:8.23 thymus:8.30 bone marrow:8.56 adipose:7.42 bone:- skin:7.88
CAGE cerebrum:3.14 cerebellum:- brain stem:3.07 corpus callosum/glia:3.04 pineal gland:3.44 peripheral nerve:- spine:3.66 retina:- eye:- artery/aorta:3.95 vein:4.08 lymphnode:4.43 peripheral blood:- spleen:3.75 thymus:4.20 bone marrow:- adipose:3.83 bone:- skin:-
RNA-seq cerebrum:1.09 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.62 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:154.90 placenta:36.40 prostate:33.80 ovary:37.30 testis:86.50 heart:76.60 muscle:20.10 esophagus:- stomach:63.70 intestine:129.60 colon:76.30     liver/hepato:42.20        lung:107.50    bladder:251.20 kidney:104 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:130.10 salivary:-
GeneChip uterus:7.74 placenta:7.23 prostate:7.28 ovary:7.45 testis:7.05 heart:7.11 muscle:6.33 esophagus:8.17 stomach:7.58 intestine:7.13 colon:7.66 liver/hepato:7.29 lung:7.86 bladder:- kidney:7.17 pituitary:6.72 thyroid/parathyroid:6.96 adrenal gland:6.86 pancreas:5.35 breast:7.79 salivary:7.18
CAGE uterus:3.82 placenta:3.47 prostate:3.63 ovary:3.17 testis:3.90 heart:3.87 muscle:3.20 esophagus:3.75 stomach:- intestine:4.12 colon:4.45     liver/hepato:3.46    lung:3.95 bladder:3.84 kidney:3.52 pituitary:3.17 thyroid/parathyroid:2.86 adrenal gland:- pancreas:2.76 breast:4.40 salivary:3.45
RNA-seq uterus:- placenta:- prostate:4.08 ovary:3.84 testis:3.75 heart:3.18 muscle:2.43 esophagus:- stomach:- intestine:- colon:3.82     liver/hepato:3.15        lung:3.65    bladder:- kidney:4.02 pituitary:- thyroid/parathyroid:2.66 adrenal gland:3.65 pancreas:- breast:4.17 salivary:-

Gene Information

IDs

Refseq ID NM_007271
Gene ID 11329
Unigene ID Hs.409578
Probe set ID 202951_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000112079
GTEx ID ENSG00000112079

Orthologous Gene

Mouse[1]  NM_134115
Rat [0]  

Chromosomal Region

6p21.31  [36,461,669  -  36,515,247]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7761441
9647638
9774336
12477932
12493777
14574404
14661952
15067004
15197186
15324660
15489334
15582665
15670829
16135814
16884686
17317633
17620599
17707232
17906693
18029348
18362890
19058789
19062280
19167051
19327996
19875983
19919647
20360068
20624913
21139048
21262772
21730291
21906983
21942715
21963094
22142472
22268729
22354994
22505724
22674419
22939624
22952844
23022380
23084401
23178486
23184937
23402259
23886587
23897809
24250222
24657165
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0043407  negative regulation of MAP kinase activity
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0006464  protein modification process

Cellular Component

GO:0005737  cytoplasm
GO:0043231  intracellular membrane-bounded organelle
GO:0070688  MLL5-L complex
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity