monoglyceride lipase

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Synonym

MGL, Monoglyceride lipase, MGLL, HU-K5, monoglyceride lipase, Lysophospholipase-like, Lysophospholipase homolog

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:123.30 cerebellum:138.50 brain stem:- corpus callosum/glia:29.20 pineal gland:296.70 peripheral nerve:61.30 spine:- retina:118.60 eye:176.30 artery/aorta:30 vein:399.90 lymphnode:40.40 peripheral blood:145.70 spleen:208 thymus:38.70 bone marrow:39.40 adipose:201.70 bone:51.20 skin:96
GeneChip cerebrum:8.44 cerebellum:8.72 brain stem:7.83 corpus callosum/glia:7.46 pineal gland:- peripheral nerve:8.82 spine:7.76 retina:- eye:- artery/aorta:8.83 vein:9.03 lymphnode:7.33 peripheral blood:- spleen:8.72 thymus:6.11 bone marrow:7.13 adipose:10.03 bone:- skin:8.27
CAGE cerebrum:4.09 cerebellum:- brain stem:3.63 corpus callosum/glia:3.44 pineal gland:3.40 peripheral nerve:- spine:3.18 retina:- eye:- artery/aorta:4.37 vein:4.28 lymphnode:3.62 peripheral blood:- spleen:3.43 thymus:2.17 bone marrow:- adipose:5.20 bone:- skin:-
RNA-seq cerebrum:4.17 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.13 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.09 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:94.70 prostate:78.90 ovary:74.50 testis:21.60 heart:89.40 muscle:120.50 esophagus:- stomach:42.50 intestine:32.40 colon:220.50     liver/hepato:147.80        lung:166.20    bladder:- kidney:124.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:139.40 salivary:328.40
GeneChip uterus:7.59 placenta:7.59 prostate:7.28 ovary:7 testis:6.28 heart:8.97 muscle:7.95 esophagus:9.85 stomach:8.29 intestine:7.96 colon:9.16 liver/hepato:8.92 lung:8.72 bladder:- kidney:8.85 pituitary:6.75 thyroid/parathyroid:6.89 adrenal gland:7.37 pancreas:6.50 breast:8.95 salivary:8.38
CAGE uterus:3.34 placenta:3.83 prostate:3.17 ovary:2.73 testis:2.79 heart:4.70 muscle:4.44 esophagus:4.36 stomach:- intestine:3.75 colon:4.44     liver/hepato:4.34    lung:4.29 bladder:3.45 kidney:4.08 pituitary:2.53 thyroid/parathyroid:2.59 adrenal gland:- pancreas:1.42 breast:4.89 salivary:3.70
RNA-seq uterus:- placenta:- prostate:4.60 ovary:2.56 testis:3.45 heart:4.29 muscle:3.46 esophagus:- stomach:- intestine:- colon:4.79     liver/hepato:5.05        lung:4.72    bladder:- kidney:4.81 pituitary:- thyroid/parathyroid:3.29 adrenal gland:4.00 pancreas:- breast:6.83 salivary:-

Gene Information

IDs

Refseq ID NM_001003794
Gene ID 11343
Unigene ID Hs.277035
Probe set ID 211026_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000074416
GTEx ID ENSG00000074416

Orthologous Gene

Mouse[10]  NM_001166249, NM_001166250, NM_001166251, NM_011844
Rat[1]  NM_138502, NM_001166250, NM_001166251, NM_011844

Chromosomal Region

3q21.3  [127,407,909  -  127,558,019]

Gene Family (Interpro ID)

IPR000073  Alpha/beta hydrolase fold-1

Link to Pubmed  (Pubmed ID)

8619474
8889548
9110174
9495531
11470505
12477932
14702039
15342556
15489334
16169070
16344560
16806233
17621164
18452279
18721756
19014633
19233690
19913121
19957260
19962385
20079333
20464001
20628086
20855465
20976246
21118518
21308848
21543155
21802006
22349814
22664939
22827915
23455058
23509962
23553709
24368842

Gene Ontology  (GO ID)

Biological Process

GO:0046464  acylglycerol catabolic process
GO:0019369  arachidonic acid metabolic process
GO:0007596  blood coagulation
GO:0006633  fatty acid biosynthetic process
GO:0046474  glycerophospholipid biosynthetic process
GO:0006954  inflammatory response
GO:0006629  lipid metabolic process
GO:0060292  long term synaptic depression
GO:0006644  phospholipid metabolic process
GO:0030168  platelet activation
GO:0050727  regulation of inflammatory response
GO:0051930  regulation of sensory perception of pain
GO:0009966  regulation of signal transduction
GO:0019433  triglyceride catabolic process

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0005886  plasma membrane
GO:0045202  synapse

Molecular Function

GO:0047372  acylglycerol lipase activity
GO:0004091  carboxylesterase activity
GO:0008289  lipid binding
GO:0004622  lysophospholipase activity
GO:0042803  protein homodimerization activity