cholinergic receptor, nicotinic, beta 2 (neuronal)

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Synonym

cholinergic receptor, nicotinic, beta 2 (neuronal), EFNL3, CHRNB2, nAChRB2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.10 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:41.10 artery/aorta:89.90 vein:- lymphnode:50.60 peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:40.30 bone:12.80 skin:33.60
GeneChip cerebrum:7.34 cerebellum:7.28 brain stem:7.37 corpus callosum/glia:7.18 pineal gland:- peripheral nerve:7.05 spine:7.14 retina:- eye:- artery/aorta:7.42 vein:7.49 lymphnode:7.38 peripheral blood:- spleen:7.07 thymus:6.99 bone marrow:7.44 adipose:7.33 bone:- skin:7.51
CAGE cerebrum:3.18 cerebellum:- brain stem:1.94 corpus callosum/glia:1.91 pineal gland:3.46 peripheral nerve:- spine:1.43 retina:- eye:- artery/aorta:0.18 vein:0 lymphnode:0.06 peripheral blood:- spleen:0.09 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:2.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.06 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:65.60 prostate:709.70 ovary:- testis:47.60 heart:51.10 muscle:140.60 esophagus:- stomach:- intestine:97.20 colon:212     liver/hepato:10.60        lung:34.20    bladder:125.60 kidney:114.40 pituitary:116 thyroid/parathyroid:327.50 adrenal gland:101.60 pancreas:53.30 breast:9.30 salivary:-
GeneChip uterus:7.20 placenta:7.01 prostate:7.13 ovary:7.29 testis:7.16 heart:7.34 muscle:7.52 esophagus:7.37 stomach:7.21 intestine:7.35 colon:7.48 liver/hepato:7.48 lung:7.31 bladder:- kidney:7.42 pituitary:7.42 thyroid/parathyroid:7.43 adrenal gland:7.56 pancreas:7.65 breast:7.22 salivary:7.47
CAGE uterus:0.06 placenta:0 prostate:0.15 ovary:0.14 testis:0.04 heart:0 muscle:0 esophagus:0 stomach:- intestine:0.27 colon:0.12     liver/hepato:0    lung:0 bladder:0.18 kidney:0.15 pituitary:2.29 thyroid/parathyroid:0 adrenal gland:- pancreas:0.94 breast:0 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.09 ovary:0.08 testis:0.49 heart:0.01 muscle:0 esophagus:- stomach:- intestine:- colon:0.14     liver/hepato:0        lung:0.03    bladder:- kidney:0.08 pituitary:- thyroid/parathyroid:0.01 adrenal gland:0.09 pancreas:- breast:0.15 salivary:-

Gene Information

IDs

Refseq ID NM_000748
Gene ID 1141
Unigene ID Hs.230601
Probe set ID 206635_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000160716
GTEx ID ENSG00000160716

Orthologous Gene

Mouse[1]  NM_009602
Rat [0]  

Chromosomal Region

1q21.3  [154,540,257  -  154,552,502]

Gene Family (Interpro ID)

IPR006201  Neurotransmitter-gated ion-channel

Link to Pubmed  (Pubmed ID)

1397297
1505988
2377478
8906617
8987816
9009220
9921897
10441742
10771020
11054772
11062464
11104662
11261808
11771745
11906688
11952766
12185808
12189247
12202488
12214130
12477932
12663058
12681012
15026168
15033200
15046869
15154117
15489334
15681842
15944128
15964197
16023355
16174636
16183856
16238698
16314871
16407231
16636791
16928859
17192785
17226798
17373692
17385675
17559419
17900292
18043764
18226955
18242781
18534558
18534914
18593715
18762859
18830724
18991851
19058950
19059502
19063970
19086053
19101612
19156168
19259974
19279256
19482438
19620239
19755656
19874574
20231857
20301348
20371741
20413850
20441771
20534741
20574532
20603624
20649589
20677014
20734064
20736995
20854418
20880607
20881005
20923852
20943775
21252231
21287502
21396349
21451042
21536845
21606948
21757735
22359659
22553201
23000369
23037950
23429692
23437071
23734673

Gene Ontology  (GO ID)

Biological Process

GO:0008306  associative learning
GO:0042113  B cell activation
GO:0035095  behavioral response to nicotine
GO:0006816  calcium ion transport
GO:0021952  central nervous system projection neuron axonogenesis
GO:0050890  cognition
GO:0001661  conditioned taste aversion
GO:0006811  ion transport
GO:0021771  lateral geniculate nucleus development
GO:0007612  learning
GO:0007626  locomotory behavior
GO:0051899  membrane depolarization
GO:0007613  memory
GO:0045759  negative regulation of action potential
GO:0050877  neurological system process
GO:0021631  optic nerve morphogenesis
GO:0030890  positive regulation of B cell proliferation
GO:0033603  positive regulation of dopamine secretion
GO:0032226  positive regulation of synaptic transmission, dopaminergic
GO:0045188  regulation of circadian sleep/wake cycle, non-REM sleep
GO:0042320  regulation of circadian sleep/wake cycle, REM sleep
GO:0048814  regulation of dendrite morphogenesis
GO:0042053  regulation of dopamine metabolic process
GO:0014059  regulation of dopamine secretion
GO:0032225  regulation of synaptic transmission, dopaminergic
GO:0051963  regulation of synaptogenesis
GO:0042220  response to cocaine
GO:0045471  response to ethanol
GO:0001666  response to hypoxia
GO:0035094  response to nicotine
GO:0019233  sensory perception of pain
GO:0007605  sensory perception of sound
GO:0007165  signal transduction
GO:0006939  smooth muscle contraction
GO:0035176  social behavior
GO:0007268  synaptic transmission
GO:0060084  synaptic transmission involved in micturition
GO:0007271  synaptic transmission, cholinergic
GO:0021562  vestibulocochlear nerve development
GO:0008542  visual learning
GO:0007601  visual perception

Cellular Component

GO:0030054  cell junction
GO:0009897  external side of plasma membrane
GO:0016021  integral to membrane
GO:0005892  nicotinic acetylcholine-gated receptor-channel complex
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane

Molecular Function

GO:0042166  acetylcholine binding
GO:0015464  acetylcholine receptor activity
GO:0015276  ligand-gated ion channel activity
GO:0004889  nicotinic acetylcholine-activated cation-selective channel activity