toll-interleukin 1 receptor (TIR) domain containing adaptor protein

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Synonym

MyD88 adapter-like protein, Adaptor protein Wyatt, FLJ42305, TIRAP, TIR domain-containing adapter protein, wyatt, Mal

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:- retina:118.60 eye:17.60 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:18.20 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:33.60
GeneChip nodata
CAGE cerebrum:1.87 cerebellum:- brain stem:1.66 corpus callosum/glia:1.87 pineal gland:2.45 peripheral nerve:- spine:1.98 retina:- eye:- artery/aorta:2.81 vein:2.60 lymphnode:2.77 peripheral blood:- spleen:2.79 thymus:1.52 bone marrow:- adipose:2.42 bone:- skin:-
RNA-seq cerebrum:0.16 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:14.60 prostate:33.80 ovary:74.50 testis:- heart:12.80 muscle:20.10 esophagus:- stomach:1741.90 intestine:- colon:-     liver/hepato:-        lung:34.20    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:26.70 breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:2.73 placenta:2.40 prostate:2.68 ovary:2.65 testis:1.69 heart:2.46 muscle:2.31 esophagus:2.51 stomach:- intestine:3.04 colon:3.11     liver/hepato:2.76    lung:2.82 bladder:2.69 kidney:2.45 pituitary:2.57 thyroid/parathyroid:2.25 adrenal gland:- pancreas:2.98 breast:3.09 salivary:3.05
RNA-seq uterus:- placenta:- prostate:0.09 ovary:0.44 testis:0.06 heart:0.11 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.20     liver/hepato:0.08        lung:0.00    bladder:- kidney:0.29 pituitary:- thyroid/parathyroid:0.29 adrenal gland:0.21 pancreas:- breast:0.02 salivary:-

Gene Ontology  (GO ID)

Biological Process

GO:0070935  3'-UTR-mediated mRNA stabilization
GO:0007166  cell surface receptor linked signal transduction
GO:0071221  cellular response to bacterial lipopeptide
GO:0071223  cellular response to lipoteichoic acid
GO:0050830  defense response to Gram-positive bacterium
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0030099  myeloid cell differentiation
GO:0044130  negative regulation of growth of symbiont in host
GO:0030890  positive regulation of B cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032735  positive regulation of interleukin-12 production
GO:0032738  positive regulation of interleukin-15 production
GO:0045410  positive regulation of interleukin-6 biosynthetic process
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0090073  positive regulation of protein homodimerization activity
GO:0034137  positive regulation of toll-like receptor 2 signaling pathway
GO:0034141  positive regulation of toll-like receptor 3 signaling pathway
GO:0034145  positive regulation of toll-like receptor 4 signaling pathway
GO:0032760  positive regulation of tumor necrosis factor production
GO:0045088  regulation of innate immune response
GO:0032648  regulation of interferon-beta production
GO:0032496  response to lipopolysaccharide
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030139  endocytic vesicle
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0005515  protein binding
GO:0030674  protein binding, bridging
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0005080  protein kinase C binding