membrane-associated ring finger (C3HC4) 3

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Synonym

RNF173, RING finger protein 173, MARCH3, Membrane-associated RING-CH protein III, membrane-associated ring finger (C3HC4) 3, Membrane-associated RING finger protein 3, MGC48332, MARCH-III

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.40 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:296.70 peripheral nerve:- spine:- retina:- eye:99.90 artery/aorta:- vein:- lymphnode:40.40 peripheral blood:- spleen:18.90 thymus:25.80 bone marrow:39.40 adipose:- bone:- skin:-
GeneChip cerebrum:5.12 cerebellum:5.25 brain stem:5.13 corpus callosum/glia:5.58 pineal gland:- peripheral nerve:4.69 spine:6.53 retina:- eye:- artery/aorta:5.29 vein:5.42 lymphnode:5.14 peripheral blood:- spleen:5.09 thymus:4.74 bone marrow:6.37 adipose:5.34 bone:- skin:6.03
CAGE cerebrum:2.50 cerebellum:- brain stem:2.80 corpus callosum/glia:2.90 pineal gland:3.29 peripheral nerve:- spine:3.68 retina:- eye:- artery/aorta:2.77 vein:2.74 lymphnode:2.56 peripheral blood:- spleen:1.80 thymus:1.80 bone marrow:- adipose:2.75 bone:- skin:-
RNA-seq cerebrum:1.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.57 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.90 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:14.60 prostate:11.30 ovary:- testis:56.20 heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:42.40     liver/hepato:10.60        lung:29.30    bladder:- kidney:- pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:17.80 breast:46.50 salivary:-
GeneChip uterus:4.65 placenta:5.14 prostate:4.44 ovary:4.88 testis:7.64 heart:6.37 muscle:5.39 esophagus:4.71 stomach:5.02 intestine:5.35 colon:6.01 liver/hepato:4.36 lung:5.12 bladder:- kidney:4.35 pituitary:5.33 thyroid/parathyroid:4.73 adrenal gland:5.88 pancreas:4.92 breast:5.35 salivary:7.02
CAGE uterus:2.02 placenta:2.10 prostate:2.11 ovary:2.33 testis:3.54 heart:3.34 muscle:2.50 esophagus:1.83 stomach:- intestine:2.07 colon:3.04     liver/hepato:1.16    lung:2.47 bladder:2.71 kidney:1.53 pituitary:3.08 thyroid/parathyroid:2.16 adrenal gland:- pancreas:2.18 breast:2.64 salivary:3.27
RNA-seq uterus:- placenta:- prostate:1.42 ovary:1.16 testis:2.38 heart:1.84 muscle:0.48 esophagus:- stomach:- intestine:- colon:2.27     liver/hepato:0.34        lung:1.68    bladder:- kidney:0.62 pituitary:- thyroid/parathyroid:1.02 adrenal gland:2.38 pancreas:- breast:1.04 salivary:-

Gene Information

IDs

Refseq ID NM_178450
Gene ID 115123
Unigene ID Hs.132441
Probe set ID 213256_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000173926
GTEx ID ENSG00000173926

Orthologous Gene

Mouse[1]  NM_177115
Rat[1]  NM_001007759

Chromosomal Region

5q23.2  [126,203,406  -  126,366,500]

Gene Family (Interpro ID)

IPR018957  Zinc finger, C3HC4 RING-type
IPR011016  Zinc finger, RING-CH-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

8619474
9110174
12477932
14722266
15489334
16428329
19549727
21832049

Gene Ontology  (GO ID)

Biological Process

GO:0006897  endocytosis
GO:0016567  protein ubiquitination

Cellular Component

GO:0030659  cytoplasmic vesicle membrane
GO:0031901  early endosome membrane
GO:0005768  endosome
GO:0016021  integral to membrane
GO:0005764  lysosome

Molecular Function

GO:0016874  ligase activity
GO:0008270  zinc ion binding