cytokine inducible SH2-containing protein

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Synonym

Suppressor of cytokine signaling, Cytokine-inducible SH2-containing protein, SOCS, CISH, CIS-1, cytokine inducible SH2-containing protein, Protein G18, G18, CIS

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.03 cerebellum:6.04 brain stem:5.94 corpus callosum/glia:5.99 pineal gland:- peripheral nerve:6.24 spine:6.25 retina:- eye:- artery/aorta:6.61 vein:6.47 lymphnode:6.64 peripheral blood:- spleen:6.55 thymus:6.34 bone marrow:6.85 adipose:6.72 bone:- skin:6.88
CAGE cerebrum:1.14 cerebellum:- brain stem:1.26 corpus callosum/glia:1.01 pineal gland:0.64 peripheral nerve:- spine:2.24 retina:- eye:- artery/aorta:2.50 vein:3.04 lymphnode:2.80 peripheral blood:- spleen:2.84 thymus:3.30 bone marrow:- adipose:3.31 bone:- skin:-
RNA-seq cerebrum:1.06 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.95 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.68 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.43 placenta:7.79 prostate:6.27 ovary:6.45 testis:6.31 heart:6.45 muscle:6.32 esophagus:6.62 stomach:6.46 intestine:6.62 colon:6.66 liver/hepato:7.12 lung:6.86 bladder:- kidney:7.02 pituitary:6.87 thyroid/parathyroid:6.90 adrenal gland:6.30 pancreas:7.30 breast:6.98 salivary:6.63
CAGE uterus:2.80 placenta:4.60 prostate:2.65 ovary:3.21 testis:1.81 heart:3.23 muscle:3.17 esophagus:2.86 stomach:- intestine:2.63 colon:2.86     liver/hepato:4.20    lung:4.07 bladder:2.58 kidney:4.03 pituitary:2.25 thyroid/parathyroid:4.14 adrenal gland:- pancreas:2.81 breast:4.51 salivary:3.77
RNA-seq uterus:- placenta:- prostate:2.63 ovary:2.89 testis:1.89 heart:1.11 muscle:3.25 esophagus:- stomach:- intestine:- colon:1.68     liver/hepato:4.08        lung:4.30    bladder:- kidney:3.99 pituitary:- thyroid/parathyroid:4.11 adrenal gland:2.15 pancreas:- breast:2.22 salivary:-

Gene Information

IDs

Refseq ID NM_145071
Gene ID 1154
Unigene ID -
Probe set ID 221223_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000114737
GTEx ID ENSG00000114737

Orthologous Gene

Mouse[1]  NM_009895
Rat[1]  NM_031804

Chromosomal Region

3p21.2  [50,643,921  -  50,649,262]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7796808
9465889
9774439
10514520
10517496
10585430
10902923
10969179
11032736
11713228
12076535
12077274
12477932
12586763
12618484
12648219
14630083
14707129
15231748
15470047
15489334
15644415
16273093
16344560
16684815
16961462
17666591
18420585
18508766
18647318
18820827
19592657
19595407
19622774
19807022
19913121
20484391
20628086
21234523
21383382
21988832
22033525
22213096
22817871
23426819
23867815
23898208
24131863

Gene Ontology  (GO ID)

Biological Process

GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0009968  negative regulation of signal transduction
GO:0016567  protein ubiquitination
GO:0001558  regulation of cell growth

Cellular Component

GO:0005575  cellular_component
GO:0005829  cytosol

Molecular Function

GO:0003674  molecular_function