adenylate cyclase activating polypeptide 1 (pituitary)

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Synonym

MGC126852, PACAP, ADCYAP1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.68 cerebellum:4.23 brain stem:4.81 corpus callosum/glia:3.97 pineal gland:- peripheral nerve:5.09 spine:4.31 retina:- eye:- artery/aorta:4.04 vein:4.11 lymphnode:3.84 peripheral blood:- spleen:3.88 thymus:3.86 bone marrow:4.07 adipose:3.91 bone:- skin:3.88
CAGE cerebrum:1.80 cerebellum:- brain stem:1.89 corpus callosum/glia:0.96 pineal gland:0.35 peripheral nerve:- spine:2.22 retina:- eye:- artery/aorta:1.48 vein:1.92 lymphnode:0.93 peripheral blood:- spleen:0.25 thymus:0.64 bone marrow:- adipose:0.84 bone:- skin:-
RNA-seq cerebrum:0.69 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.12 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.99 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:- salivary:-
GeneChip uterus:3.96 placenta:4.01 prostate:3.94 ovary:3.85 testis:4.07 heart:4.01 muscle:4.24 esophagus:4.08 stomach:4.01 intestine:4.02 colon:4.08 liver/hepato:3.94 lung:3.84 bladder:- kidney:4.02 pituitary:4.05 thyroid/parathyroid:3.87 adrenal gland:3.91 pancreas:4.28 breast:3.92 salivary:4.07
CAGE uterus:1.39 placenta:0.24 prostate:0.44 ovary:0.68 testis:1.86 heart:0.99 muscle:0.24 esophagus:2.29 stomach:- intestine:0.99 colon:1.76     liver/hepato:0.14    lung:1.17 bladder:2.19 kidney:0.08 pituitary:1.83 thyroid/parathyroid:0.17 adrenal gland:- pancreas:1.74 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.09 testis:0.70 heart:0.00 muscle:0 esophagus:- stomach:- intestine:- colon:1.56     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.34 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001099733
Gene ID 116
Unigene ID Hs.531719
Probe set ID 206281_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000141433
GTEx ID ENSG00000141433

Orthologous Gene

Mouse[1]  NM_009625
Rat[1]  NM_009625

Chromosomal Region

18p11.32  [904,414  -  912,173]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1335692
1483839
1544422
1730060
1739432
2302217
7680413
8146174
8253796
8353512
8504103
8577931
9313778
9346858
9603988
10562300
10583729
10698193
10921074
11175907
11350957
11515750
11713978
11968092
11972030
12145407
12409223
12409225
12417650
12429744
12477932
12504599
12573802
12686458
12716746
12754213
12948842
15036651
15048918
15356166
15489334
15518890
15834139
16148159
16226889
16344560
16493055
16687279
16697281
16805430
16888207
16939974
17175032
17387318
17430174
17431645
17470806
17962362
18349695
18353507
18782879
19086053
19120039
19269029
19470168
19701709
19712974
19805477
19914336
19926922
20034524
20072116
20133634
20180986
20414143
20468064
20500521
20554694
20671407
20675276
21109983
21259400
21350482
21383633
21388403
21898124
22108610
22415357
22539193
22581436
22610912
22638857
22644900
22648511
23147486
23220033
23251661
23598374
24041830
24220567
24696141

Gene Ontology  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0046034  ATP metabolic process
GO:0001662  behavioral fear response
GO:0007267  cell-cell signaling
GO:0071385  cellular response to glucocorticoid stimulus
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007565  female pregnancy
GO:0001821  histamine secretion
GO:0002865  negative regulation of acute inflammatory response to antigenic stimulus
GO:0002878  negative regulation of acute inflammatory response to non-antigenic stimulus
GO:0045786  negative regulation of cell cycle
GO:0060253  negative regulation of glial cell proliferation
GO:0043267  negative regulation of potassium ion transport
GO:0034259  negative regulation of Rho GTPase activity
GO:0048011  nerve growth factor receptor signaling pathway
GO:0001541  ovarian follicle development
GO:0021983  pituitary gland development
GO:0010579  positive regulation of adenylate cyclase activity by G-protein signaling pathway
GO:0008284  positive regulation of cell proliferation
GO:0060124  positive regulation of growth hormone secretion
GO:0032755  positive regulation of interleukin-6 production
GO:0010976  positive regulation of neuron projection development
GO:0051968  positive regulation of synaptic transmission, glutamatergic
GO:0045909  positive regulation of vasodilation
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0070445  regulation of oligodendrocyte progenitor proliferation
GO:0060078  regulation of postsynaptic membrane potential
GO:0032880  regulation of protein localization
GO:0045471  response to ethanol
GO:0042594  response to starvation
GO:0019233  sensory perception of pain
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0043195  terminal button

Molecular Function

GO:0005184  neuropeptide hormone activity
GO:0051428  peptide hormone receptor binding
GO:0016521  pituitary adenylate cyclase activating polypeptide activity
GO:0031858  pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0005102  receptor binding
GO:0005057  receptor signaling protein activity