adaptor-related protein complex 3, sigma 1 subunit

 jump to detail

Synonym

AP3S1, Sigma-3A-adaptin, AP-3 complex subunit sigma-1, Adapter-related protein complex 3 sigma-1 subunit, adaptor-related protein complex 3, sigma 1 subunit, AP-3 complex sigma-3A subunit, CLAPS3, Sigma3A, Sigma-adaptin 3a

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.65 cerebellum:8.40 brain stem:8.81 corpus callosum/glia:8.15 pineal gland:- peripheral nerve:8.77 spine:8.47 retina:- eye:- artery/aorta:8.93 vein:8.99 lymphnode:8.47 peripheral blood:- spleen:8.28 thymus:8.32 bone marrow:8.92 adipose:9.03 bone:- skin:8.91
CAGE cerebrum:3.44 cerebellum:- brain stem:3.48 corpus callosum/glia:2.94 pineal gland:3.22 peripheral nerve:- spine:3.26 retina:- eye:- artery/aorta:4.11 vein:3.12 lymphnode:3.27 peripheral blood:- spleen:2.98 thymus:2.91 bone marrow:- adipose:3.31 bone:- skin:-
RNA-seq cerebrum:5.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.60 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.68 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:9.21 placenta:8.84 prostate:8.63 ovary:9.09 testis:9.05 heart:8.41 muscle:7.69 esophagus:8.86 stomach:8.55 intestine:8.65 colon:8.41 liver/hepato:8.08 lung:8.48 bladder:- kidney:8.09 pituitary:8.65 thyroid/parathyroid:8.67 adrenal gland:8.40 pancreas:9 breast:8.78 salivary:9.02
CAGE uterus:3.26 placenta:3.49 prostate:3.35 ovary:3.50 testis:3.75 heart:3.40 muscle:2.30 esophagus:3.43 stomach:- intestine:3.89 colon:3.34     liver/hepato:3.24    lung:3.25 bladder:3.56 kidney:3.00 pituitary:3.66 thyroid/parathyroid:3.45 adrenal gland:- pancreas:3.96 breast:3.90 salivary:3.34
RNA-seq uterus:- placenta:- prostate:6.07 ovary:6.05 testis:6.04 heart:4.58 muscle:3.88 esophagus:- stomach:- intestine:- colon:6.07     liver/hepato:4.83        lung:5.34    bladder:- kidney:5.02 pituitary:- thyroid/parathyroid:5.44 adrenal gland:5.10 pancreas:- breast:5.74 salivary:-

Gene Information

IDs

Refseq ID NM_001284
Gene ID 1176
Unigene ID -
Probe set ID 202442_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000177879
GTEx ID ENSG00000177879

Orthologous Gene

Mouse[1]  NM_009681
Rat[1]  NM_001106933

Chromosomal Region

5q22.3  [115,177,178  -  115,249,778]

Gene Family (Interpro ID)

IPR016635  Adaptor protein complex, sigma subunit
IPR000804  Clathrin adaptor, sigma subunit/coatomer, zeta subunit

Link to Pubmed  (Pubmed ID)

8697810
9118953
9151686
9792713
12370188
12477932
12967569
14657250
14702039
15469849
15489334
16162817
18076669
19322201
20379614
20512086
21139048
21890473
21906983
21963094
22505724
22863883
22875976
22939629
22990118
23000965
23125841
24797263

Gene Ontology  (GO ID)

Biological Process

GO:0008089  anterograde axon cargo transport
GO:0048490  anterograde synaptic vesicle transport
GO:0008286  insulin receptor signaling pathway
GO:0006886  intracellular protein transport

Cellular Component

GO:0030123  AP-3 adaptor complex
GO:0030119  AP-type membrane coat adaptor complex
GO:0030659  cytoplasmic vesicle membrane
GO:0005794  Golgi apparatus
GO:0030133  transport vesicle

Molecular Function

GO:0005515  protein binding
GO:0008565  protein transporter activity
GO:0005215  transporter activity