chloride channel 3

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Synonym

ClC-3, CLCN3, chloride channel 3, Chloride channel protein 3, CLC3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:139.80 cerebellum:125.90 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:153.40 spine:336.90 retina:118.60 eye:117.50 artery/aorta:89.90 vein:66.60 lymphnode:91 peripheral blood:- spleen:- thymus:38.70 bone marrow:59 adipose:80.70 bone:12.80 skin:201.60
GeneChip cerebrum:8.63 cerebellum:8.67 brain stem:8.84 corpus callosum/glia:8.87 pineal gland:- peripheral nerve:8.54 spine:9.14 retina:- eye:- artery/aorta:6.40 vein:6.47 lymphnode:7.14 peripheral blood:- spleen:7.03 thymus:7.07 bone marrow:7.60 adipose:7.37 bone:- skin:7.61
CAGE cerebrum:4.95 cerebellum:- brain stem:5.10 corpus callosum/glia:5.09 pineal gland:5.87 peripheral nerve:- spine:5.34 retina:- eye:- artery/aorta:3.60 vein:3.36 lymphnode:3.81 peripheral blood:- spleen:3.82 thymus:3.85 bone marrow:- adipose:3.80 bone:- skin:-
RNA-seq cerebrum:4.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.88 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:69.20 prostate:123.90 ovary:37.30 testis:73.50 heart:63.90 muscle:- esophagus:- stomach:21.20 intestine:- colon:110.20     liver/hepato:84.40        lung:88    bladder:- kidney:83.20 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:97.80 breast:74.30 salivary:-
GeneChip uterus:7.16 placenta:7.43 prostate:8.62 ovary:7.63 testis:7.83 heart:7.82 muscle:7.49 esophagus:8.09 stomach:7.36 intestine:7.70 colon:7.08 liver/hepato:7.13 lung:7.25 bladder:- kidney:7.51 pituitary:8.76 thyroid/parathyroid:7.79 adrenal gland:7.95 pancreas:7.98 breast:7.72 salivary:9.37
CAGE uterus:3.89 placenta:4.20 prostate:3.97 ovary:3.76 testis:4.44 heart:4.30 muscle:3.68 esophagus:4.35 stomach:- intestine:4.28 colon:4.07     liver/hepato:3.76    lung:3.89 bladder:4.08 kidney:4.34 pituitary:5.24 thyroid/parathyroid:3.87 adrenal gland:- pancreas:4.28 breast:3.24 salivary:5.55
RNA-seq uterus:- placenta:- prostate:1.98 ovary:3.07 testis:3.21 heart:3.19 muscle:2.81 esophagus:- stomach:- intestine:- colon:3.05     liver/hepato:2.70        lung:2.89    bladder:- kidney:4.07 pituitary:- thyroid/parathyroid:3.05 adrenal gland:1.80 pancreas:- breast:3.31 salivary:-

Gene Information

IDs

Refseq ID NM_001829
Gene ID 1182
Unigene ID Hs.481186
Probe set ID 201734_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000109572
GTEx ID ENSG00000109572

Orthologous Gene

Mouse[30]  NM_007711, NM_173873, NM_173874, NM_173876
Rat [0]  

Chromosomal Region

4q33  [170,533,784  -  170,644,824]

Gene Family (Interpro ID)

IPR002245  Chloride channel CLC-3
IPR001807  Chloride channel, voltage gated

Link to Pubmed  (Pubmed ID)

7665160
9521585
9678416
9843494
10198195
11076863
11230166
11274166
11306429
11967229
12183454
12471024
12477932
12842831
12843258
15073168
15342556
15489336
15596438
16033995
16344560
16381901
16522634
17360969
17869465
17882904
17908687
17976378
17977943
18077605
18986326
19946888
20139089
20945353
21071705
21115901
21378974
21445064
21792908
22049206
22108225
22371056
22496242
23006728
23270726
23345219
23408563
23873092

Gene Ontology  (GO ID)

Biological Process

GO:0048388  endosomal lumen acidification
GO:0034220  ion transmembrane transport
GO:0006885  regulation of pH
GO:0055085  transmembrane transport
GO:0006810  transport

Cellular Component

GO:0016324  apical plasma membrane
GO:0009986  cell surface
GO:0005769  early endosome
GO:0031901  early endosome membrane
GO:0005794  Golgi apparatus
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0005770  late endosome
GO:0031902  late endosome membrane
GO:0030658  transport vesicle membrane
GO:0012506  vesicle membrane

Molecular Function

GO:0015297  antiporter activity
GO:0005524  ATP binding
GO:0005254  chloride channel activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0005247  voltage-gated chloride channel activity