CDC-like kinase 2

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Synonym

hCLK2, clk2, MGC61500, Dual specificity protein kinase CLK2, CLK2, CDC-like kinase 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:34.40 cerebellum:37.80 brain stem:- corpus callosum/glia:58.30 pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:58.80 artery/aorta:30 vein:- lymphnode:91 peripheral blood:54.70 spleen:18.90 thymus:64.40 bone marrow:118.10 adipose:80.70 bone:64 skin:52.80
GeneChip cerebrum:7.02 cerebellum:7.37 brain stem:7 corpus callosum/glia:7.23 pineal gland:- peripheral nerve:7.26 spine:6.97 retina:- eye:- artery/aorta:7.66 vein:6.93 lymphnode:8.31 peripheral blood:- spleen:8.23 thymus:8.26 bone marrow:7.70 adipose:7.56 bone:- skin:7.81
CAGE cerebrum:3.17 cerebellum:- brain stem:3.19 corpus callosum/glia:3.46 pineal gland:3.16 peripheral nerve:- spine:2.98 retina:- eye:- artery/aorta:3.22 vein:3.29 lymphnode:3.43 peripheral blood:- spleen:3.05 thymus:3.23 bone marrow:- adipose:3.01 bone:- skin:-
RNA-seq cerebrum:1.85 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.70 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.44 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:32.80 prostate:78.90 ovary:149.10 testis:30.30 heart:63.90 muscle:- esophagus:- stomach:- intestine:64.80 colon:17     liver/hepato:31.70        lung:44    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:65.10 salivary:-
GeneChip uterus:8 placenta:7.73 prostate:8.05 ovary:7.98 testis:7.67 heart:7.03 muscle:7.01 esophagus:7.57 stomach:7.60 intestine:7.28 colon:7.38 liver/hepato:7.58 lung:7.70 bladder:- kidney:7.48 pituitary:8.03 thyroid/parathyroid:8 adrenal gland:7.89 pancreas:6.58 breast:7.95 salivary:7.50
CAGE uterus:3.60 placenta:3.40 prostate:3.44 ovary:3.32 testis:3.03 heart:2.92 muscle:2.58 esophagus:3.01 stomach:- intestine:2.97 colon:3.39     liver/hepato:2.65    lung:2.92 bladder:3.06 kidney:2.74 pituitary:3.47 thyroid/parathyroid:3.22 adrenal gland:- pancreas:2.98 breast:2.91 salivary:3.13
RNA-seq uterus:- placenta:- prostate:3.75 ovary:3.25 testis:2.64 heart:1.73 muscle:2.40 esophagus:- stomach:- intestine:- colon:2.60     liver/hepato:2.25        lung:2.64    bladder:- kidney:3.15 pituitary:- thyroid/parathyroid:3.20 adrenal gland:3.63 pancreas:- breast:2.27 salivary:-

Gene Information

IDs

Refseq ID NM_003993
Gene ID 1196
Unigene ID Hs.73986
Probe set ID 203229_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000176444
GTEx ID ENSG00000176444

Orthologous Gene

Mouse[2]  NM_001163432, NM_007712
Rat[2]  NM_001014254, NM_031724

Chromosomal Region

1q22  [155,232,659  -  155,248,282]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7990150
8910305
9331372
9637771
9758629
9852100
9856501
10480872
11285245
11579209
12477932
12705895
14702039
14759258
15324660
15489334
16189514
16344560
17384638
18978788
18995830
19097996
19168442
19282290
20064461
20682768
21682887
21988832
22939624
23376537
23602568
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0045721  negative regulation of gluconeogenesis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0043484  regulation of RNA splicing
GO:0010212  response to ionizing radiation
GO:0032526  response to retinoic acid

Cellular Component

GO:0016607  nuclear speck
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0004712  protein serine/threonine/tyrosine kinase activity
GO:0004713  protein tyrosine kinase activity