U2AF homology motif (UHM) kinase 1

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Synonym

U2AF homology motif kinase 1, KIST, Kist, KIS, UHMK1, U2AF homology motif (UHM) kinase 1, Kinase interacting with stathmin, Serine/threonine-protein kinase Kist

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:66.60 lymphnode:60.70 peripheral blood:36.40 spleen:18.90 thymus:- bone marrow:- adipose:- bone:- skin:19.20
GeneChip nodata
CAGE cerebrum:4.11 cerebellum:- brain stem:4.32 corpus callosum/glia:4.05 pineal gland:3.23 peripheral nerve:- spine:3.89 retina:- eye:- artery/aorta:3.59 vein:3.90 lymphnode:4.20 peripheral blood:- spleen:4.21 thymus:4.11 bone marrow:- adipose:4.19 bone:- skin:-
RNA-seq cerebrum:1.14 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.61 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.37 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:21.90 prostate:- ovary:- testis:13 heart:- muscle:20.10 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:14.70    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:88.90 breast:46.50 salivary:-
GeneChip nodata
CAGE uterus:3.47 placenta:3.91 prostate:3.54 ovary:3.43 testis:3.62 heart:3.57 muscle:3.72 esophagus:3.64 stomach:- intestine:4.23 colon:3.94     liver/hepato:4.22    lung:4.13 bladder:3.49 kidney:4.06 pituitary:3.71 thyroid/parathyroid:3.70 adrenal gland:- pancreas:3.57 breast:4.35 salivary:3.68
RNA-seq uterus:- placenta:- prostate:0.63 ovary:0.46 testis:1.12 heart:1.64 muscle:0.77 esophagus:- stomach:- intestine:- colon:1.12     liver/hepato:0.00        lung:0.10    bladder:- kidney:0.64 pituitary:- thyroid/parathyroid:1.69 adrenal gland:0.48 pancreas:- breast:1.65 salivary:-

Gene Information

IDs

Refseq ID NM_175866
Gene ID 127933
Unigene ID Hs.127310
Probe set ID -
Ensembl ID ENSG00000152332
GTEx ID ENSG00000152332

Orthologous Gene

Mouse[6]  NM_010633
Rat [0]  

Chromosomal Region

1q23.3  [162,467,041  -  162,499,419]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR000504  RNA recognition motif, RNP-1
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7724523
10574929
12093740
12477932
12782393
15489334
16710414
16978587
17474147
17726090
17984092
18316326
18384876
18414510
19322201
19747464
21399567
21906983
21963094
22505724
23419774

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0031175  neuron projection development
GO:0018105  peptidyl-serine phosphorylation
GO:0045948  positive regulation of translational initiation
GO:0046777  protein amino acid autophosphorylation
GO:0046825  regulation of protein export from nucleus

Cellular Component

GO:0030424  axon
GO:0032839  dendrite cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0019899  enzyme binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0043021  ribonucleoprotein binding
GO:0003723  RNA binding
GO:0016740  transferase activity