IQ motif containing GTPase activating protein 3

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Synonym

MGC10831, MGC10170, IQGAP3, IQ motif containing GTPase activating protein 3, Ras GTPase-activating-like protein IQGAP3, MGC1947

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:30.30 peripheral blood:- spleen:- thymus:- bone marrow:39.40 adipose:- bone:- skin:19.20
GeneChip nodata
CAGE cerebrum:0.00 cerebellum:- brain stem:0.03 corpus callosum/glia:0.07 pineal gland:0.26 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:0 vein:0.47 lymphnode:0.97 peripheral blood:- spleen:0.39 thymus:1.73 bone marrow:- adipose:0.78 bone:- skin:-
RNA-seq cerebrum:0.18 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.04 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:74.50 testis:13 heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:101.80     liver/hepato:21.10        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:46.50 salivary:-
GeneChip nodata
CAGE uterus:0.36 placenta:1.35 prostate:0.27 ovary:0.07 testis:1.21 heart:0.20 muscle:0.09 esophagus:1.68 stomach:- intestine:1.86 colon:2.28     liver/hepato:0    lung:0.46 bladder:0.09 kidney:0.27 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.04 ovary:0.11 testis:0.90 heart:0.09 muscle:0.06 esophagus:- stomach:- intestine:- colon:0.27     liver/hepato:0.06        lung:0.15    bladder:- kidney:0.11 pituitary:- thyroid/parathyroid:0.10 adrenal gland:0.10 pancreas:- breast:0.21 salivary:-

Gene Information

IDs

Refseq ID NM_178229
Gene ID 128239
Unigene ID Hs.591495
Probe set ID -
Ensembl ID ENSG00000183856
GTEx ID ENSG00000183856

Orthologous Gene

Mouse[1]  NM_001033484
Rat [0]  

Chromosomal Region

1q23.1  [156,495,197  -  156,542,396]

Gene Family (Interpro ID)

IPR016146  Calponin-homology
IPR001715  Calponin-like actin-binding
IPR001936  Ras GTPase-activating protein
IPR008936  Rho GTPase activation protein

Link to Pubmed  (Pubmed ID)

12477932
14702039
17244649
17314511
19322201
20360068
20800603
21139048
21565611
21890473
22505724
23000965
23667531
23956138
24639526
24778252

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0071310  cellular response to organic substance
GO:0070371  ERK1 and ERK2 cascade
GO:0000082  G1/S transition of mitotic cell cycle
GO:0010629  negative regulation of gene expression
GO:0010628  positive regulation of gene expression
GO:0033601  positive regulation of mammary gland epithelial cell proliferation
GO:0007265  Ras protein signal transduction
GO:0008361  regulation of cell size

Cellular Component

GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0016328  lateral plasma membrane

Molecular Function

GO:0005516  calmodulin binding
GO:0005099  Ras GTPase activator activity
GO:0017048  Rho GTPase binding