mitogen-activated protein kinase kinase kinase 8

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Synonym

mitogen-activated protein kinase kinase kinase 8, COT proto-oncogene serine/threonine-protein kinase, MAP3K8, C-COT, EST, TPL2, Mitogen-activated protein kinase kinase kinase 8, c-COT, COT, Cancer Osaka thyroid oncogene, ESTF, Tpl-2, FLJ10486

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:22.50 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:5.90 artery/aorta:30 vein:266.60 lymphnode:50.60 peripheral blood:236.80 spleen:37.80 thymus:25.80 bone marrow:19.70 adipose:40.30 bone:51.20 skin:33.60
GeneChip cerebrum:2.91 cerebellum:2.88 brain stem:3.05 corpus callosum/glia:2.97 pineal gland:- peripheral nerve:3.38 spine:3.15 retina:- eye:- artery/aorta:4 vein:3.96 lymphnode:4.15 peripheral blood:- spleen:5.04 thymus:3.31 bone marrow:4 adipose:3.98 bone:- skin:4.86
CAGE cerebrum:1.99 cerebellum:- brain stem:2.16 corpus callosum/glia:1.94 pineal gland:2.43 peripheral nerve:- spine:2.95 retina:- eye:- artery/aorta:4.24 vein:3.52 lymphnode:3.85 peripheral blood:- spleen:3.88 thymus:1.67 bone marrow:- adipose:3.78 bone:- skin:-
RNA-seq cerebrum:0.88 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.33 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.90 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:87.40 prostate:33.80 ovary:- testis:8.70 heart:51.10 muscle:- esophagus:- stomach:- intestine:32.40 colon:25.40     liver/hepato:31.70        lung:68.40    bladder:125.60 kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:74.30 salivary:-
GeneChip uterus:3.79 placenta:5.74 prostate:3.92 ovary:3.89 testis:2.76 heart:3.56 muscle:3.23 esophagus:3.83 stomach:3.51 intestine:3.56 colon:3.17 liver/hepato:3.26 lung:5.82 bladder:- kidney:3.06 pituitary:2.94 thyroid/parathyroid:3.58 adrenal gland:3.94 pancreas:3.01 breast:3.86 salivary:3
CAGE uterus:3.07 placenta:3.88 prostate:2.88 ovary:3.03 testis:2.21 heart:3.49 muscle:2.55 esophagus:3.33 stomach:- intestine:2.55 colon:2.54     liver/hepato:2.58    lung:3.67 bladder:3.26 kidney:2.54 pituitary:1.81 thyroid/parathyroid:2.45 adrenal gland:- pancreas:1.87 breast:3.99 salivary:2.01
RNA-seq uterus:- placenta:- prostate:1.84 ovary:1.26 testis:1.06 heart:1.59 muscle:0.43 esophagus:- stomach:- intestine:- colon:1.02     liver/hepato:1.59        lung:3.29    bladder:- kidney:1.74 pituitary:- thyroid/parathyroid:1.20 adrenal gland:3.10 pancreas:- breast:2.89 salivary:-

Gene Information

IDs

Refseq ID NM_005204
Gene ID 1326
Unigene ID Hs.432453
Probe set ID 205027_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000107968
GTEx ID ENSG00000107968

Orthologous Gene

Mouse[1]  NM_007746
Rat [0]  

Chromosomal Region

10p11.23  [30,722,866  -  30,750,762]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1833717
2072910
8226782
8479752
8631303
8889549
9257820
9603908
9742107
9950430
10072079
10669751
10896655
11278268
11932422
12138205
12477932
12667451
12975377
14517305
14743216
15164054
15169888
15188402
15287022
15466476
15489334
15575964
15670770
16087150
16291755
16344560
16371247
16385451
16565081
16806191
17290588
17324460
17398070
17724252
17848581
18029348
18187448
18319612
18439422
18518937
18572386
18795070
18984674
19001140
19054068
19272346
19804365
19939924
19953087
20227498
20379614
20487506
20603871
20945381
21107320
21267413
21539449
21741362
21868363
21988832
22197930
22939624
23125217
23128233
23252623
23322277
23527104
23533274
23828905
23982215
24275658
24404585

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0006468  protein amino acid phosphorylation
GO:0031295  T cell costimulation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0004709  MAP kinase kinase kinase activity
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity