adenosine A1 receptor

 jump to detail

Synonym

RDC7, ADORA1, Adenosine A1 receptor, adenosine A1 receptor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:147 cerebellum:50.40 brain stem:- corpus callosum/glia:116.60 pineal gland:- peripheral nerve:- spine:- retina:- eye:35.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:- bone marrow:- adipose:- bone:38.40 skin:4.80
GeneChip cerebrum:6.87 cerebellum:5.70 brain stem:6.81 corpus callosum/glia:7 pineal gland:- peripheral nerve:4.77 spine:6.21 retina:- eye:- artery/aorta:4.77 vein:4.85 lymphnode:4.28 peripheral blood:- spleen:4.77 thymus:4.09 bone marrow:4.76 adipose:5.08 bone:- skin:4.82
CAGE cerebrum:4.07 cerebellum:- brain stem:4.47 corpus callosum/glia:4.61 pineal gland:2.18 peripheral nerve:- spine:4.00 retina:- eye:- artery/aorta:0.47 vein:1.53 lymphnode:0.78 peripheral blood:- spleen:1.50 thymus:0.06 bone marrow:- adipose:1.12 bone:- skin:-
RNA-seq cerebrum:1.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:32.80 prostate:- ovary:- testis:73.50 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:18.60 salivary:-
GeneChip uterus:4.49 placenta:5.47 prostate:4.11 ovary:4.56 testis:6.31 heart:5.25 muscle:4.66 esophagus:4.56 stomach:4.67 intestine:5 colon:4.61 liver/hepato:4.87 lung:4.38 bladder:- kidney:4.90 pituitary:4.63 thyroid/parathyroid:4.46 adrenal gland:4.31 pancreas:5.86 breast:4.83 salivary:5.20
CAGE uterus:0.73 placenta:2.38 prostate:0.62 ovary:0.89 testis:3.49 heart:1.85 muscle:0.94 esophagus:0.68 stomach:- intestine:0.33 colon:0.66     liver/hepato:0.14    lung:1.04 bladder:1.02 kidney:2.00 pituitary:0.83 thyroid/parathyroid:1.32 adrenal gland:- pancreas:2.86 breast:1.92 salivary:2.35
RNA-seq uterus:- placenta:- prostate:0.22 ovary:0.18 testis:0.16 heart:0.47 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.22 pituitary:- thyroid/parathyroid:0.53 adrenal gland:0.00 pancreas:- breast:0.52 salivary:-

Gene Information

IDs

Refseq ID NM_000674
Gene ID 134
Unigene ID Hs.77867
Probe set ID 205481_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000163485
GTEx ID ENSG00000163485

Orthologous Gene

Mouse[4]  NM_001008533, NM_001039510
Rat [0]  

Chromosomal Region

1q32.1  [203,059,782  -  203,136,533]

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR001068  Adenosine A1 receptor
IPR001634  Adenosine receptor
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

1339301
1530647
1551861
1662665
2541503
2825071
7601478
7818494
8300646
8360491
8450977
8889548
9166747
9247966
10455026
10487528
10502296
10521440
10890919
11278325
11369591
11390975
11703426
11934694
12150791
12475223
12477932
12764156
12773115
12812995
12825092
12826838
12920396
12974671
14702039
14997566
15257174
15485865
15489334
16118787
16344560
16481441
16709961
16713569
17088462
17542617
17728764
17901362
18052973
18240029
18281812
18373090
18500760
18577758
18680557
18996102
19019012
19019667
19047957
19193874
19207864
19536175
19558453
19574994
19794965
19820430
19822392
19883624
19913121
19919976
20085598
20105183
20354569
20392501
20468064
20599769
20602615
20609566
20628086
21506953
21542986
21590734
21603615
21701065
21730968
21988832
22215671
22356216
22370739
22449383
22462821
22787201
22867902
23193172
23657626
23682121
23813214

Gene Ontology  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0007267  cell-cell signaling
GO:0050890  cognition
GO:0050965  detection of temperature stimulus involved in sensory perception of pain
GO:0006954  inflammatory response
GO:0007193  inhibition of adenylate cyclase activity by G-protein signaling pathway
GO:0016042  lipid catabolic process
GO:0002674  negative regulation of acute inflammatory response
GO:0043066  negative regulation of apoptosis
GO:0045776  negative regulation of blood pressure
GO:0055118  negative regulation of cardiac muscle contraction
GO:0008285  negative regulation of cell proliferation
GO:0042323  negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0014050  negative regulation of glutamate secretion
GO:0045822  negative regulation of heart contraction
GO:0046888  negative regulation of hormone secretion
GO:0002686  negative regulation of leukocyte migration
GO:0050995  negative regulation of lipid catabolic process
GO:0070256  negative regulation of mucus secretion
GO:0032900  negative regulation of neurotrophin production
GO:0032229  negative regulation of synaptic transmission, GABAergic
GO:0051967  negative regulation of synaptic transmission, glutamatergic
GO:0045908  negative regulation of vasodilation
GO:0007399  nervous system development
GO:0006909  phagocytosis
GO:0045777  positive regulation of blood pressure
GO:0045741  positive regulation of epidermal growth factor receptor activity
GO:0032244  positive regulation of nucleoside transport
GO:0002793  positive regulation of peptide secretion
GO:0043268  positive regulation of potassium ion transport
GO:0035307  positive regulation of protein amino acid dephosphorylation
GO:0006612  protein targeting to membrane
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0003093  regulation of glomerular filtration
GO:0002087  regulation of respiratory gaseous exchange by neurological system process
GO:0048167  regulation of synaptic plasticity
GO:0060087  relaxation of vascular smooth muscle
GO:0001666  response to hypoxia
GO:0007165  signal transduction
GO:0001659  temperature homeostasis

Cellular Component

GO:0032279  asymmetric synapse
GO:0030673  axolemma
GO:0016323  basolateral plasma membrane
GO:0043025  cell soma
GO:0030425  dendrite
GO:0012505  endomembrane system
GO:0005783  endoplasmic reticulum
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0048786  presynaptic active zone
GO:0042734  presynaptic membrane
GO:0043195  terminal button

Molecular Function

GO:0001609  adenosine receptor activity, G-protein coupled
GO:0031683  G-protein beta/gamma-subunit binding
GO:0001664  G-protein-coupled receptor binding
GO:0032795  heterotrimeric G-protein binding
GO:0004629  phospholipase C activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0001883  purine nucleoside binding