corticotropin releasing hormone

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Synonym

Corticotropin-releasing hormone, corticotropin releasing hormone, CRF, Corticoliberin precursor, CRH, Corticotropin-releasing factor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:11.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.58 cerebellum:3.66 brain stem:3.81 corpus callosum/glia:3.85 pineal gland:- peripheral nerve:3.68 spine:3.76 retina:- eye:- artery/aorta:3.60 vein:3.75 lymphnode:3.54 peripheral blood:- spleen:3.56 thymus:3.65 bone marrow:4.71 adipose:3.62 bone:- skin:3.58
CAGE cerebrum:1.42 cerebellum:- brain stem:0.58 corpus callosum/glia:1.44 pineal gland:0.98 peripheral nerve:- spine:0.36 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0.12 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.69 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:295.10 prostate:- ovary:- testis:- heart:- muscle:20.10 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:151.10 breast:- salivary:-
GeneChip uterus:3.57 placenta:11.51 prostate:3.48 ovary:3.55 testis:3.64 heart:3.65 muscle:3.87 esophagus:3.39 stomach:3.63 intestine:3.76 colon:3.65 liver/hepato:3.87 lung:3.77 bladder:- kidney:3.56 pituitary:3.65 thyroid/parathyroid:3.57 adrenal gland:3.73 pancreas:4.89 breast:3.62 salivary:3.54
CAGE uterus:0 placenta:6.98 prostate:0.27 ovary:0 testis:0.12 heart:0 muscle:0 esophagus:0 stomach:- intestine:0.07 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0.24 thyroid/parathyroid:0 adrenal gland:- pancreas:1.21 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.49 ovary:0 testis:0.28 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0.08 salivary:-

Gene Information

IDs

Refseq ID NM_000756
Gene ID 1392
Unigene ID Hs.75294
Probe set ID 205630_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000147571
GTEx ID ENSG00000147571

Orthologous Gene

Mouse[1]  NM_205769
Rat [0]  

Chromosomal Region

8q13.1  [67,088,620  -  67,090,960]

Gene Family (Interpro ID)

IPR000187  Corticotropin-releasing factor, CRF

Link to Pubmed  (Pubmed ID)

2365075
2783917
3259914
3262120
6605851
7477348
7489943
7585095
7589495
7867564
8161822
8243338
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12036966
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12114295
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12734882
12784189
12853091
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14573312
14576187
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14706771
15072543
15077295
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15468147
15489334
15591024
15816833
15883387
16222669
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19379831
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23466050
23477585
23478074
23593457
23644483
23666959
23849813
23928667
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23987517
24597258

Gene Ontology  (GO ID)

Biological Process

GO:0030325  adrenal gland development
GO:0008306  associative learning
GO:0071314  cellular response to cocaine
GO:0016101  diterpenoid metabolic process
GO:0007631  feeding behavior
GO:0007565  female pregnancy
GO:0033494  ferulate metabolic process
GO:0006704  glucocorticoid biosynthetic process
GO:0021854  hypothalamus development
GO:0008628  induction of apoptosis by hormones
GO:0006954  inflammatory response
GO:0050801  ion homeostasis
GO:0007611  learning or memory
GO:0007616  long-term memory
GO:0030324  lung development
GO:0045776  negative regulation of blood pressure
GO:0060548  negative regulation of cell death
GO:0042322  negative regulation of circadian sleep/wake cycle, REM sleep
GO:0032811  negative regulation of epinephrine secretion
GO:0010629  negative regulation of gene expression
GO:0070093  negative regulation of glucagon secretion
GO:0033685  negative regulation of luteinizing hormone secretion
GO:0010700  negative regulation of norepinephrine secretion
GO:0007567  parturition
GO:0051461  positive regulation of adrenocorticotropin secretion
GO:0030819  positive regulation of cAMP biosynthetic process
GO:0010942  positive regulation of cell death
GO:0008284  positive regulation of cell proliferation
GO:0010841  positive regulation of circadian sleep/wake cycle, wakefulness
GO:0051464  positive regulation of cortisol secretion
GO:0060456  positive regulation of digestive system process
GO:0010628  positive regulation of gene expression
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0014062  regulation of serotonin secretion
GO:0051412  response to corticosterone stimulus
GO:0042493  response to drug
GO:0043627  response to estrogen stimulus
GO:0045471  response to ethanol
GO:0045472  response to ether
GO:0048265  response to pain
GO:0007165  signal transduction
GO:0007268  synaptic transmission
GO:0001963  synaptic transmission, dopaminergic

Cellular Component

GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0043204  perikaryon
GO:0043196  varicosity

Molecular Function

GO:0017045  adrenocorticotropin-releasing hormone activity
GO:0051430  corticotropin-releasing hormone receptor 1 binding
GO:0051431  corticotropin-releasing hormone receptor 2 binding
GO:0005179  hormone activity
GO:0005184  neuropeptide hormone activity
GO:0005515  protein binding
GO:0005102  receptor binding