NIMA (never in mitosis gene a)-related kinase 7

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Synonym

Serine/threonine-protein kinase Nek7, NIMA (never in mitosis gene a)-related kinase 7, NimA-related protein kinase 7, NEK7

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:28.40 cerebellum:12.60 brain stem:- corpus callosum/glia:233.30 pineal gland:- peripheral nerve:30.70 spine:- retina:355.90 eye:52.90 artery/aorta:89.90 vein:133.30 lymphnode:60.70 peripheral blood:18.20 spleen:- thymus:51.50 bone marrow:59 adipose:- bone:12.80 skin:81.60
GeneChip cerebrum:7.23 cerebellum:5.72 brain stem:7.53 corpus callosum/glia:8.23 pineal gland:- peripheral nerve:8.01 spine:8.12 retina:- eye:- artery/aorta:7.76 vein:8.32 lymphnode:7.22 peripheral blood:- spleen:7.83 thymus:7.84 bone marrow:6.64 adipose:8.27 bone:- skin:7.18
CAGE cerebrum:4.15 cerebellum:- brain stem:4.38 corpus callosum/glia:4.75 pineal gland:3.89 peripheral nerve:- spine:4.75 retina:- eye:- artery/aorta:4.84 vein:4.25 lymphnode:3.98 peripheral blood:- spleen:4.26 thymus:4.22 bone marrow:- adipose:4.99 bone:- skin:-
RNA-seq cerebrum:3.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.58 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:214.90 prostate:33.80 ovary:37.30 testis:21.60 heart:76.60 muscle:180.80 esophagus:- stomach:- intestine:- colon:33.90     liver/hepato:52.80        lung:63.50    bladder:- kidney:62.40 pituitary:- thyroid/parathyroid:163.70 adrenal gland:101.60 pancreas:62.20 breast:83.60 salivary:-
GeneChip uterus:7.85 placenta:9.28 prostate:7.90 ovary:8 testis:6.12 heart:8.94 muscle:8.16 esophagus:7.02 stomach:7.29 intestine:7.42 colon:6.01 liver/hepato:6.99 lung:8.19 bladder:- kidney:6.76 pituitary:6.99 thyroid/parathyroid:7.56 adrenal gland:8.11 pancreas:6.09 breast:7.55 salivary:7.08
CAGE uterus:4.66 placenta:5.10 prostate:4.57 ovary:4.22 testis:3.91 heart:5.15 muscle:4.37 esophagus:4.45 stomach:- intestine:4.25 colon:4.27     liver/hepato:3.90    lung:4.71 bladder:4.81 kidney:3.89 pituitary:4.29 thyroid/parathyroid:4.11 adrenal gland:- pancreas:3.34 breast:4.72 salivary:4.17
RNA-seq uterus:- placenta:- prostate:5.31 ovary:4.37 testis:4.70 heart:6.76 muscle:5.47 esophagus:- stomach:- intestine:- colon:5.59     liver/hepato:3.23        lung:5.29    bladder:- kidney:4.62 pituitary:- thyroid/parathyroid:4.71 adrenal gland:3.92 pancreas:- breast:6.62 salivary:-

Gene Information

IDs

Refseq ID NM_133494
Gene ID 140609
Unigene ID Hs.24119
Probe set ID 212530_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000151414
GTEx ID ENSG00000151414

Orthologous Gene

Mouse[3]  NM_021605
Rat[1]  NM_001108346

Chromosomal Region

1q31.3  [198,126,093  -  198,291,550]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10964517
11701951
12840024
17101132
17353931
17586473
17727698
19414596
19454010
19941817
20056645
20508983
20562859
21139048
21642957
21890473
22100915
22505724
23000965
23313050
23359173
23821772
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0000910  cytokinesis
GO:0006468  protein amino acid phosphorylation
GO:0007346  regulation of mitotic cell cycle
GO:0051225  spindle assembly

Cellular Component

GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0005815  microtubule organizing center
GO:0005634  nucleus
GO:0000922  spindle pole

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0004674  protein serine/threonine kinase activity