dual specificity phosphatase 19

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Synonym

MGC138210, DUSP19, Dual specificity protein phosphatase 19, SKRP1, DUSP17, Protein phosphatase SKRP1, TS-DSP1, dual specificity phosphatase 19

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:12.80 skin:-
GeneChip nodata
CAGE cerebrum:2.51 cerebellum:- brain stem:1.62 corpus callosum/glia:1.63 pineal gland:2.12 peripheral nerve:- spine:1.69 retina:- eye:- artery/aorta:2.77 vein:1.53 lymphnode:1.02 peripheral blood:- spleen:1.46 thymus:2.21 bone marrow:- adipose:1.33 bone:- skin:-
RNA-seq cerebrum:0.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.14 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:3.60 prostate:- ovary:- testis:26 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:- salivary:-
GeneChip nodata
CAGE uterus:2.04 placenta:0.95 prostate:2.10 ovary:1.48 testis:2.24 heart:2.16 muscle:0.67 esophagus:2.01 stomach:- intestine:1.73 colon:1.58     liver/hepato:0.90    lung:1.55 bladder:1.88 kidney:1.58 pituitary:2.55 thyroid/parathyroid:1.79 adrenal gland:- pancreas:1.98 breast:0.55 salivary:1.89
RNA-seq uterus:- placenta:- prostate:0.96 ovary:1.81 testis:1.79 heart:1.73 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.47     liver/hepato:0.27        lung:0.92    bladder:- kidney:1.25 pituitary:- thyroid/parathyroid:0.39 adrenal gland:0.97 pancreas:- breast:0.92 salivary:-

Gene Information

IDs

Refseq ID NM_080876
Gene ID 142679
Unigene ID Hs.132237
Probe set ID -
Ensembl ID ENSG00000162999
GTEx ID ENSG00000162999

Orthologous Gene

Mouse[2]  NM_024438
Rat[1]  NM_001107739

Chromosomal Region

2q32.1  [183,943,287  -  183,964,733]

Gene Family (Interpro ID)

IPR020417  Dual specificity phosphatase
IPR000340  Dual specificity phosphatase, catalytic domain
IPR020422  Dual specificity phosphatase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

11959861
11959862
12477932
12479873
14702039
15489334
15815621
19228121
19322201
21989941

Gene Ontology  (GO ID)

Biological Process

GO:0000188  inactivation of MAPK activity
GO:0007254  JNK cascade
GO:0046329  negative regulation of JNK cascade
GO:0043508  negative regulation of JUN kinase activity
GO:0006469  negative regulation of protein kinase activity
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0045860  positive regulation of protein kinase activity
GO:0006470  protein amino acid dephosphorylation

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0008579  JUN kinase phosphatase activity
GO:0005078  MAP-kinase scaffold activity
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0030295  protein kinase activator activity
GO:0004860  protein kinase inhibitor activity
GO:0004725  protein tyrosine phosphatase activity
GO:0008330  protein tyrosine/threonine phosphatase activity