c-src tyrosine kinase

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Synonym

Protein-tyrosine kinase CYL, C-SRC kinase, c-src tyrosine kinase, CSK, MGC117393, Tyrosine-protein kinase CSK

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:22.50

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:58.80

artery/aorta:60

vein:-

lymphnode:252.80

peripheral blood:255.10

spleen:378.10

thymus:103.10

bone marrow:98.40

adipose:-

bone:38.40

skin:28.80

GeneChip

cerebrum:6.76

cerebellum:6.99

brain stem:7.05

corpus callosum/glia:7.14

pineal gland:-

peripheral nerve:6.80

spine:7.13

retina:-

eye:-

artery/aorta:6.81

vein:6.67

lymphnode:9.01

peripheral blood:-

spleen:9.05

thymus:8.15

bone marrow:7.74

adipose:7

bone:-

skin:7.11

CAGE

cerebrum:4.02

cerebellum:-

brain stem:4.18

corpus callosum/glia:4.18

pineal gland:4.18

peripheral nerve:-

spine:4.20

retina:-

eye:-

artery/aorta:3.80

vein:5.13

lymphnode:5.52

peripheral blood:-

spleen:5.53

thymus:5.61

bone marrow:-

adipose:3.98

bone:-

skin:-

RNA-seq

cerebrum:2.64

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.28

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.58

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:21.90

prostate:33.80

ovary:37.30

testis:34.60

heart:12.80

muscle:-

esophagus:-

stomach:21.20

intestine:97.20

colon:84.80

liver/hepato:21.10

lung:48.90

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:46.50

salivary:328.40

GeneChip

uterus:6.83

placenta:6.53

prostate:6.63

ovary:6.86

testis:6.92

heart:6.97

muscle:6.41

esophagus:8.46

stomach:7.50

intestine:7.17

colon:7.74

liver/hepato:7.35

lung:7.57

bladder:-

kidney:6.95

pituitary:6.84

thyroid/parathyroid:7.02

adrenal gland:6.98

pancreas:6.39

breast:7.41

salivary:7.33

CAGE

uterus:4.02

placenta:3.82

prostate:4.04

ovary:3.97

testis:4.04

heart:4.00

muscle:2.97

esophagus:4.73

stomach:-

intestine:4.64

colon:4.41

liver/hepato:4.60

lung:4.38

bladder:3.62

kidney:3.80

pituitary:3.67

thyroid/parathyroid:3.76

adrenal gland:-

pancreas:3.59

breast:4.28

salivary:4.18

RNA-seq

uterus:-

placenta:-

prostate:3.04

ovary:4.00

testis:3.91

heart:2.44

muscle:1.96

esophagus:-

stomach:-

intestine:-

colon:2.91

liver/hepato:3.63

lung:3.52

bladder:-

kidney:3.14

pituitary:-

thyroid/parathyroid:2.72

adrenal gland:5.69

pancreas:-

breast:3.32

salivary:-

IDs

Refseq ID	NM_001127190
Gene ID	1445
Unigene ID	Hs.77793
Probe set ID	202329_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000103653
GTEx ID	ENSG00000103653

Orthologous Gene

Mouse[1]	NM_007783
Rat [0]

Chromosomal Region

15q24.1 [75,074,425 - 75,095,539]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0034332	adherens junction organization
GO:0007596	blood coagulation
GO:0007420	brain development
GO:0071375	cellular response to peptide hormone stimulus
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0045779	negative regulation of bone resorption
GO:0008285	negative regulation of cell proliferation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0042997	negative regulation of Golgi to plasma membrane protein transport
GO:0032715	negative regulation of interleukin-6 production
GO:0033673	negative regulation of kinase activity
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0050765	negative regulation of phagocytosis
GO:0048709	oligodendrocyte differentiation
GO:0030168	platelet activation
GO:0043406	positive regulation of MAP kinase activity
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005911	cell-cell junction
GO:0005813	centrosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0070064	proline-rich region binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019903	protein phosphatase binding
GO:0004713	protein tyrosine kinase activity

c-src tyrosine kinase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function