toll-like receptor adaptor molecule 1

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Synonym

TRIF, MGC35334, toll-like receptor adaptor molecule 1, TICAM-1, PRVTIRB, TICAM1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:41.10 artery/aorta:- vein:66.60 lymphnode:70.80 peripheral blood:18.20 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.35 cerebellum:5.25 brain stem:5.21 corpus callosum/glia:5.16 pineal gland:- peripheral nerve:5.23 spine:5.11 retina:- eye:- artery/aorta:5.77 vein:5.99 lymphnode:5.80 peripheral blood:- spleen:5.69 thymus:4.78 bone marrow:5.37 adipose:5.58 bone:- skin:6.03
CAGE cerebrum:2.69 cerebellum:- brain stem:2.69 corpus callosum/glia:2.70 pineal gland:2.63 peripheral nerve:- spine:2.63 retina:- eye:- artery/aorta:3.27 vein:2.87 lymphnode:3.06 peripheral blood:- spleen:3.08 thymus:2.15 bone marrow:- adipose:3.04 bone:- skin:-
RNA-seq cerebrum:1.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.45 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.64 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:18.20 prostate:- ovary:- testis:4.30 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:33.90     liver/hepato:-        lung:29.30    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:18.60 salivary:-
GeneChip uterus:5.49 placenta:5.18 prostate:5.24 ovary:5.39 testis:4.57 heart:5.50 muscle:5.54 esophagus:6.54 stomach:5.59 intestine:5.65 colon:5.96 liver/hepato:5.90 lung:6.16 bladder:- kidney:5.65 pituitary:5.15 thyroid/parathyroid:5.48 adrenal gland:5.51 pancreas:5.57 breast:5.65 salivary:5.75
CAGE uterus:2.84 placenta:2.54 prostate:2.88 ovary:2.77 testis:1.97 heart:2.75 muscle:2.33 esophagus:3.61 stomach:- intestine:3.67 colon:3.11     liver/hepato:2.97    lung:2.96 bladder:2.95 kidney:3.03 pituitary:2.59 thyroid/parathyroid:2.81 adrenal gland:- pancreas:2.94 breast:2.79 salivary:2.50
RNA-seq uterus:- placenta:- prostate:2.57 ovary:2.16 testis:1.66 heart:1.23 muscle:3.40 esophagus:- stomach:- intestine:- colon:1.97     liver/hepato:1.73        lung:3.70    bladder:- kidney:1.96 pituitary:- thyroid/parathyroid:2.34 adrenal gland:2.46 pancreas:- breast:1.97 salivary:-

Gene Information

IDs

Refseq ID NM_182919
Gene ID 148022
Unigene ID Hs.29344
Probe set ID 213191_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000127666
GTEx ID ENSG00000127666

Orthologous Gene

Mouse[1]  NM_174989
Rat[1]  NM_174989

Chromosomal Region

19p13.3  [4,815,939  -  4,831,737]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8619474
9110174
10066798
12471095
12477932
12539043
12609980
12692549
12721283
12761501
12855817
14517278
14519765
14530355
14556004
14739303
14960149
14982987
15064760
15142865
15251447
15276183
15474016
15611223
15767257
15814722
15940673
16052631
16115877
16153868
16306936
16323247
16964262
16968706
17982077
18442983
18450748
18571728
18756281
18810425
18987746
19028691
19423540
19543401
19656901
19734906
19795416
20047764
20200155
20306472
20331378
20375303
20406964
20418377
20438785
20452988
20588308
20639876
20855887
21048031
21148036
21212282
21324962
21536801
21695056
21697485
21792053
21809339
21903422
21906983
21931545
21988832
21998457
22043923
22095710
22105173
22152804
22205631
22337809
22474023
22561518
22870331
22948160
22964479
23056470
23365087
23673637
23723066
23824566
23962979
24129891
24311583
24577058

Gene Ontology  (GO ID)

Biological Process

GO:0051607  defense response to virus
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002281  macrophage activation during immune response
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0030890  positive regulation of B cell proliferation
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045359  positive regulation of interferon-beta biosynthetic process
GO:0032755  positive regulation of interleukin-6 production
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0032092  positive regulation of protein binding
GO:0031398  positive regulation of protein ubiquitination
GO:0032760  positive regulation of tumor necrosis factor production
GO:0032481  positive regulation of type I interferon production
GO:0043496  regulation of protein homodimerization activity
GO:0043330  response to exogenous dsRNA
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0010008  endosome membrane

Molecular Function

GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004871  signal transducer activity