NK2 transcription factor related, locus 5 (Drosophila)

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Synonym

Homeobox protein CSX, Homeobox protein NK-2 homolog E, Cardiac-specific homeobox, NKX2.5, CSX, NKX2-5, cardiac-specific homeo box, CSX1, Homeobox protein Nkx-2.5, NKX2E

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:56.70 thymus:- bone marrow:- adipose:121 bone:- skin:-
GeneChip cerebrum:5.38 cerebellum:5.29 brain stem:5.52 corpus callosum/glia:5.02 pineal gland:- peripheral nerve:4.89 spine:5 retina:- eye:- artery/aorta:5.21 vein:5.86 lymphnode:4.88 peripheral blood:- spleen:5.83 thymus:4.81 bone marrow:5.10 adipose:5.08 bone:- skin:5.23
CAGE cerebrum:0.01 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.47 vein:1.03 lymphnode:0.31 peripheral blood:- spleen:3.43 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.02 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:370.40 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.94 placenta:5.13 prostate:4.90 ovary:4.94 testis:5 heart:7.25 muscle:5.31 esophagus:5.05 stomach:5.07 intestine:5.41 colon:5.12 liver/hepato:5 lung:5.10 bladder:- kidney:5.18 pituitary:5.13 thyroid/parathyroid:4.89 adrenal gland:5.14 pancreas:5.83 breast:4.87 salivary:5.05
CAGE uterus:0 placenta:0 prostate:0 ovary:0.07 testis:0.16 heart:4.92 muscle:0 esophagus:0.18 stomach:- intestine:0 colon:0.35     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0.40 thyroid/parathyroid:0.32 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0.01 testis:0.11 heart:0.29 muscle:0.00 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.05 adrenal gland:0.00 pancreas:- breast:0.03 salivary:-

Gene Information

IDs

Refseq ID NM_001166176
Gene ID 1482
Unigene ID Hs.54473
Probe set ID 206578_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000183072
GTEx ID ENSG00000183072

Orthologous Gene

Mouse[1]  NM_008700
Rat [0]  

Chromosomal Region

5q35.1  [172,659,112  -  172,662,360]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

7665173
8887666
8900537
9312027
9651244
9748262
9858576
10206974
10587520
10903346
10948187
11431700
11714651
11889119
12023302
12074273
12122109
12414819
12477932
12499378
12775767
12798584
12845333
12858530
12858532
14500364
14607454
15109497
15161646
15340050
15342699
15363409
15489334
15542826
15649947
15653675
15917268
16137232
16138909
16344560
16418214
16556596
16678093
17308084
17584735
17891434
17891520
18076106
18079734
18084293
18219441
18492690
18547965
18579533
18689573
18851995
18939937
18976153
18983250
18997347
19049681
19073351
19181906
19217179
19302747
19371212
19464101
19479054
19533775
19564151
19595143
19913121
19948535
20021795
20022124
20062060
20137692
20157192
20211142
20456451
20487506
20561859
20606036
20628086
20725931
20807224
20932824
21091212
21110066
21152044
21165553
21188375
21262546
21276881
21519287
21561848
21815254
21931855
22011241
22043484
22179962
22192413
22306654
22560297
22576768
22647876
22666732
22824467
22849347
22920929
22959235
22964646
23285148
23525379
23583979
23644027
23661673
23751912
23778487
23936479
24041700
24182332

Gene Ontology  (GO ID)

Biological Process

GO:0007512  adult heart development
GO:0003278  apoptosis involved in heart morphogenesis
GO:0055014  atrial cardiac muscle cell development
GO:0060413  atrial septum morphogenesis
GO:0060928  atrioventricular node cell development
GO:0060929  atrioventricular node cell fate commitment
GO:0030509  BMP signaling pathway
GO:0003166  bundle of His development
GO:0003161  cardiac conduction system development
GO:0055007  cardiac muscle cell differentiation
GO:0060038  cardiac muscle cell proliferation
GO:0060048  cardiac muscle contraction
GO:0055008  cardiac muscle tissue morphogenesis
GO:0003168  cardiac Purkinje fiber cell differentiation
GO:0003211  cardiac ventricle formation
GO:0030154  cell differentiation
GO:0035050  embryonic heart tube development
GO:0060971  embryonic heart tube left/right pattern formation
GO:0001947  heart looping
GO:0003007  heart morphogenesis
GO:0060347  heart trabecula formation
GO:0030097  hemopoiesis
GO:0043066  negative regulation of apoptosis
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0010832  negative regulation of myotube differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0003148  outflow tract septum morphogenesis
GO:0060037  pharyngeal system development
GO:0051891  positive regulation of cardioblast differentiation
GO:0008284  positive regulation of cell proliferation
GO:0045823  positive regulation of heart contraction
GO:0045666  positive regulation of neuron differentiation
GO:0010765  positive regulation of sodium ion transport
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0060261  positive regulation of transcription initiation from RNA polymerase II promoter
GO:0010735  positive regulation of transcription via serum response element binding
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0003342  proepicardium development
GO:0003350  pulmonary myocardium development
GO:0060043  regulation of cardiac muscle cell proliferation
GO:0055117  regulation of cardiac muscle contraction
GO:0003221  right ventricular cardiac muscle tissue morphogenesis
GO:0045214  sarcomere organization
GO:0003285  septum secundum development
GO:0048536  spleen development
GO:0030878  thyroid gland development
GO:0001570  vasculogenesis
GO:0055015  ventricular cardiac muscle cell development
GO:0055005  ventricular cardiac myofibril development
GO:0060412  ventricular septum morphogenesis
GO:0003222  ventricular trabecular myocardium morphogenesis
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0010736  serum response element binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding