ring finger and CCCH-type zinc finger domains 1

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Synonym

RP5-1198E17.5, Roquin, KIAA2025, RC3H1, RNF198, RING finger and C3H zinc finger protein 1, roquin, ring finger and CCCH-type zinc finger domains 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:11.90 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:30 vein:- lymphnode:10.10 peripheral blood:- spleen:18.90 thymus:64.40 bone marrow:- adipose:- bone:- skin:19.20
GeneChip nodata
CAGE cerebrum:2.99 cerebellum:- brain stem:3.29 corpus callosum/glia:3.34 pineal gland:3.15 peripheral nerve:- spine:2.92 retina:- eye:- artery/aorta:2.99 vein:3.03 lymphnode:2.91 peripheral blood:- spleen:3.23 thymus:3.27 bone marrow:- adipose:3.10 bone:- skin:-
RNA-seq cerebrum:2.63 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.59 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.57 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:21.90 prostate:22.50 ovary:37.30 testis:4.30 heart:- muscle:60.30 esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:-        lung:14.70    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:65.10 salivary:-
GeneChip nodata
CAGE uterus:3.24 placenta:2.95 prostate:3.05 ovary:2.65 testis:2.86 heart:2.73 muscle:3.12 esophagus:3.02 stomach:- intestine:3.14 colon:3.26     liver/hepato:2.73    lung:2.92 bladder:2.83 kidney:2.67 pituitary:3.11 thyroid/parathyroid:2.99 adrenal gland:- pancreas:2.86 breast:2.27 salivary:2.93
RNA-seq uterus:- placenta:- prostate:2.06 ovary:2.49 testis:2.44 heart:2.25 muscle:2.37 esophagus:- stomach:- intestine:- colon:2.05     liver/hepato:1.90        lung:2.45    bladder:- kidney:2.26 pituitary:- thyroid/parathyroid:2.59 adrenal gland:2.79 pancreas:- breast:3.17 salivary:-

Gene Information

IDs

Refseq ID NM_172071
Gene ID 149041
Unigene ID Hs.30258
Probe set ID -
Ensembl ID ENSG00000135870
GTEx ID ENSG00000135870

Orthologous Gene

Mouse[1]  NM_001024952
Rat[1]  NM_001024952

Chromosomal Region

1q25.1  [173,900,352  -  173,991,435]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

12477932
14702039
15917799
16710414
18172933
19217324
20412057
20467438
21844204
22685317
22939629
23550652
23583642
23663784
23825522
24550385
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0033962  cytoplasmic mRNA processing body assembly
GO:0046007  negative regulation of activated T cell proliferation
GO:0030889  negative regulation of B cell proliferation
GO:0002635  negative regulation of germinal center formation
GO:0045623  negative regulation of T-helper cell differentiation
GO:0000956  nuclear-transcribed mRNA catabolic process
GO:0010608  posttranscriptional regulation of gene expression
GO:0002634  regulation of germinal center formation
GO:0043488  regulation of mRNA stability
GO:0050856  regulation of T cell receptor signaling pathway

Cellular Component

GO:0000932  cytoplasmic mRNA processing body
GO:0010494  stress granule

Molecular Function

GO:0003730  mRNA 3'-UTR binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding