adrenergic, alpha-2A-, receptor

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Synonym

Alpha-2A adrenoceptor, Alpha-2A adrenergic receptor, ZNF32, Alpha-2A adrenoreceptor, ALPHA2AAR, ADRA2R, ADRA2A, adrenergic, alpha-2A-, receptor, Alpha-2AAR, Alpha-2 adrenergic receptor subtype C10, ADRA2, ADRAR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:92 spine:- retina:- eye:41.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.54 cerebellum:4.77 brain stem:4.24 corpus callosum/glia:4.03 pineal gland:- peripheral nerve:5.23 spine:4.60 retina:- eye:- artery/aorta:5.30 vein:5.42 lymphnode:6.83 peripheral blood:- spleen:7.21 thymus:3.75 bone marrow:4.09 adipose:7.15 bone:- skin:5.42
CAGE cerebrum:1.82 cerebellum:- brain stem:1.57 corpus callosum/glia:1.68 pineal gland:1.23 peripheral nerve:- spine:1.77 retina:- eye:- artery/aorta:2.85 vein:3.59 lymphnode:4.16 peripheral blood:- spleen:4.74 thymus:0.71 bone marrow:- adipose:4.49 bone:- skin:-
RNA-seq cerebrum:0.89 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.77 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.94 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:14.60 prostate:11.30 ovary:74.50 testis:4.30 heart:51.10 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:53.30 breast:18.60 salivary:-
GeneChip uterus:6 placenta:5.04 prostate:4.59 ovary:5.50 testis:4.79 heart:4.83 muscle:3.89 esophagus:4.87 stomach:5.41 intestine:6.02 colon:5.92 liver/hepato:3.88 lung:4.45 bladder:- kidney:4.72 pituitary:4.29 thyroid/parathyroid:5.28 adrenal gland:4.49 pancreas:5.83 breast:6.58 salivary:4.12
CAGE uterus:4.21 placenta:2.36 prostate:3.75 ovary:3.61 testis:2.58 heart:1.87 muscle:1.29 esophagus:2.30 stomach:- intestine:2.96 colon:3.17     liver/hepato:1.25    lung:2.28 bladder:3.66 kidney:1.70 pituitary:1.23 thyroid/parathyroid:2.33 adrenal gland:- pancreas:4.35 breast:4.56 salivary:2.01
RNA-seq uterus:- placenta:- prostate:2.61 ovary:3.26 testis:2.47 heart:0.26 muscle:0.31 esophagus:- stomach:- intestine:- colon:1.89     liver/hepato:0.49        lung:1.34    bladder:- kidney:0.53 pituitary:- thyroid/parathyroid:1.39 adrenal gland:3.94 pancreas:- breast:4.94 salivary:-

Gene Information

IDs

Refseq ID NM_000681
Gene ID 150
Unigene ID Hs.249159
Probe set ID 209869_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000150594
GTEx ID ENSG00000150594

Orthologous Gene

Mouse[1]  NM_007417
Rat[1]  NM_007417

Chromosomal Region

10q25.2  [112,836,790  -  112,840,658]

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR002233  Adrenergic receptor
IPR001946  Adrenergic receptor, alpha-2A
IPR015695  Adrenergic receptor, alpha-2A/2B/2C
IPR017452  GPCR, rhodopsin-like superfamily
IPR000995  Muscarinic acetylcholine receptor

Link to Pubmed  (Pubmed ID)

1334200
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Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0032147  activation of protein kinase activity
GO:0032148  activation of protein kinase B activity
GO:0002526  acute inflammatory response
GO:0007596  blood coagulation
GO:0006928  cellular component movement
GO:0032870  cellular response to hormone stimulus
GO:0006260  DNA replication
GO:0006112  energy reserve metabolic process
GO:0042596  fear response
GO:0007565  female pregnancy
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0042593  glucose homeostasis
GO:0050892  intestinal absorption
GO:0007194  negative regulation of adenylate cyclase activity
GO:0051926  negative regulation of calcium ion transport
GO:0045955  negative regulation of calcium ion-dependent exocytosis
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0032811  negative regulation of epinephrine secretion
GO:0046676  negative regulation of insulin secretion
GO:0050995  negative regulation of lipid catabolic process
GO:0010700  negative regulation of norepinephrine secretion
GO:0070473  negative regulation of uterine smooth muscle contraction
GO:0030168  platelet activation
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001819  positive regulation of cytokine production
GO:0045741  positive regulation of epidermal growth factor receptor activity
GO:0043406  positive regulation of MAP kinase activity
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0043268  positive regulation of potassium ion transport
GO:0045909  positive regulation of vasodilation
GO:0007265  Ras protein signal transduction
GO:0050796  regulation of insulin secretion
GO:0019229  regulation of vasoconstriction
GO:0007266  Rho protein signal transduction
GO:0007165  signal transduction
GO:0050955  thermoception

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane
GO:0043235  receptor complex
GO:0045202  synapse

Molecular Function

GO:0031692  alpha-1B adrenergic receptor binding
GO:0031696  alpha-2C adrenergic receptor binding
GO:0004938  alpha2-adrenergic receptor activity
GO:0051379  epinephrine binding
GO:0032795  heterotrimeric G-protein binding
GO:0051380  norepinephrine binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0031996  thioesterase binding