salt-inducible kinase 1

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Synonym

Serine/threonine-protein kinase SNF1LK, Serine/threonine-protein kinase SNF1-like kinase 1, MSK, SNF1LK, SIK, SNF1-like kinase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.80 cerebellum:5.42 brain stem:5.80 corpus callosum/glia:5.61 pineal gland:- peripheral nerve:6.95 spine:7 retina:- eye:- artery/aorta:7.46 vein:7.65 lymphnode:7.02 peripheral blood:- spleen:7.38 thymus:6.12 bone marrow:6.44 adipose:7.56 bone:- skin:9.51
CAGE cerebrum:2.28 cerebellum:- brain stem:2.52 corpus callosum/glia:2.76 pineal gland:2.88 peripheral nerve:- spine:3.13 retina:- eye:- artery/aorta:3.63 vein:3.34 lymphnode:3.13 peripheral blood:- spleen:3.32 thymus:2.25 bone marrow:- adipose:4.70 bone:- skin:-
RNA-seq cerebrum:2.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.02 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.78 placenta:6.84 prostate:8.51 ovary:6.75 testis:6.65 heart:7.48 muscle:6 esophagus:8.17 stomach:7.24 intestine:6.87 colon:6.79 liver/hepato:7.31 lung:9.29 bladder:- kidney:7.38 pituitary:7.08 thyroid/parathyroid:6.88 adrenal gland:8.22 pancreas:7.40 breast:7.77 salivary:7.08
CAGE uterus:3.22 placenta:3.58 prostate:3.76 ovary:4.50 testis:2.59 heart:3.47 muscle:4.20 esophagus:3.77 stomach:- intestine:3.90 colon:2.96     liver/hepato:4.61    lung:4.17 bladder:4.17 kidney:2.77 pituitary:3.11 thyroid/parathyroid:2.91 adrenal gland:- pancreas:2.60 breast:3.90 salivary:3.59
RNA-seq uterus:- placenta:- prostate:4.88 ovary:5.55 testis:3.49 heart:3.11 muscle:3.47 esophagus:- stomach:- intestine:- colon:3.68     liver/hepato:3.06        lung:4.62    bladder:- kidney:3.16 pituitary:- thyroid/parathyroid:3.39 adrenal gland:3.80 pancreas:- breast:4.30 salivary:-

Gene Information

IDs

Refseq ID NM_173354
Gene ID 150094
Unigene ID -
Probe set ID 208078_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000142178
GTEx ID ENSG00000142178

Orthologous Gene

Mouse[1]  NM_010831
Rat[1]  NM_021693

Chromosomal Region

21q22.3  [44,834,395  -  44,847,008]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR000449  Ubiquitin-associated/translation elongation factor EF1B, N-terminal
IPR015940  Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

Link to Pubmed  (Pubmed ID)

7893599
9920726
10830953
12477932
14976552
16306228
16341674
16396636
17565599
17939993
18348280
18725536
18976975
19322201
19622832
20223287
20379614
21549091
21963094
21987572
21988832
22378783
22395973
23256157
23577667
24061540

Gene Ontology  (GO ID)

Biological Process

GO:0043276  anoikis
GO:0055007  cardiac muscle cell differentiation
GO:0007049  cell cycle
GO:0032792  negative regulation of CREB transcription factor activity
GO:0045721  negative regulation of gluconeogenesis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0010868  negative regulation of triglyceride biosynthetic process
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0045595  regulation of cell differentiation
GO:0007346  regulation of mitotic cell cycle
GO:0010830  regulation of myotube differentiation
GO:0002028  regulation of sodium ion transport

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0008140  cAMP response element binding protein binding
GO:0042826  histone deacetylase binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity