cytochrome P450, family 11, subfamily A, polypeptide 1

Synonym

CYP11A1, Cholesterol desmolase, P450(scc), CYPXIA1, Cholesterol side-chain cleavage enzyme, Cytochrome P450 11A1, mitochondrial precursor, CYP11A, P450SCC

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:47.40

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:29.40

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:12.90

bone marrow:-

adipose:-

bone:12.80

skin:-

GeneChip

cerebrum:4.23

cerebellum:4.19

brain stem:4.35

corpus callosum/glia:4.30

pineal gland:-

peripheral nerve:4.29

spine:4.31

retina:-

eye:-

artery/aorta:4.11

vein:4.08

lymphnode:5.04

peripheral blood:-

spleen:4.24

thymus:4.05

bone marrow:4.17

adipose:4.19

bone:-

skin:4.37

CAGE

cerebrum:0.45

cerebellum:-

brain stem:0.42

corpus callosum/glia:3.33

pineal gland:0.36

peripheral nerve:-

spine:0.71

retina:-

eye:-

artery/aorta:0.59

vein:0.59

lymphnode:0.45

peripheral blood:-

spleen:2.99

thymus:0.12

bone marrow:-

adipose:1.01

bone:-

skin:-

RNA-seq

cerebrum:0.16

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.36

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.24

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:553.70

prostate:-

ovary:37.30

testis:38.90

heart:51.10

muscle:-

esophagus:-

stomach:-

intestine:32.40

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:20.80

pituitary:116

thyroid/parathyroid:-

adrenal gland:3301.20

pancreas:-

breast:-

salivary:-

GeneChip

uterus:4.18

placenta:10.16

prostate:3.87

ovary:5.64

testis:6.67

heart:4.13

muscle:4.27

esophagus:4.79

stomach:4.11

intestine:4.13

colon:4.13

liver/hepato:4.48

lung:4.11

bladder:-

kidney:4.13

pituitary:4.38

thyroid/parathyroid:3.93

adrenal gland:11.04

pancreas:4.52

breast:4.15

salivary:4.27

CAGE

uterus:0.60

placenta:6.24

prostate:0.49

ovary:3.54

testis:4.01

heart:0.60

muscle:0.77

esophagus:0.68

stomach:-

intestine:0.21

colon:0.82

liver/hepato:1.07

lung:0.21

bladder:0.58

kidney:0.08

pituitary:0.84

thyroid/parathyroid:0.06

adrenal gland:-

pancreas:0

breast:0.90

salivary:0.36

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:3.61

testis:3.86

heart:0.00

muscle:0.16

esophagus:-

stomach:-

intestine:-

colon:0.08

liver/hepato:0.30

lung:0.00

bladder:-

kidney:0.15

pituitary:-

thyroid/parathyroid:0.10

adrenal gland:0.02

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_000781
Gene ID	1583
Unigene ID	Hs.303980
Probe set ID	204309_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000140459
GTEx ID	ENSG00000140459

Orthologous Gene

Mouse[1]	NM_019779
Rat [0]

Chromosomal Region

15q24.1 [74,630,100 - 74,660,081]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001128	Cytochrome P450
IPR002397	Cytochrome P450, B-class
IPR002401	Cytochrome P450, E-class, group I
IPR002403	Cytochrome P450, E-class, group IV

Gene Ontology (GO ID)

Biological Process

GO:0018879	biphenyl metabolic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0071236	cellular response to antibiotic
GO:0071276	cellular response to cadmium ion
GO:0071320	cellular response to cAMP
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071347	cellular response to interleukin-1
GO:0071222	cellular response to lipopolysaccharide
GO:0071375	cellular response to peptide hormone stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0021549	cerebellum development
GO:0008203	cholesterol metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0006703	estrogen biosynthetic process
GO:0050756	fractalkine metabolic process
GO:0060014	granulosa cell differentiation
GO:0021766	hippocampus development
GO:0033327	Leydig cell differentiation
GO:0060135	maternal process involved in female pregnancy
GO:0007617	mating behavior
GO:0018958	phenol metabolic process
GO:0018963	phthalate metabolic process
GO:0006701	progesterone biosynthetic process
GO:0001101	response to acid
GO:0043279	response to alkaloid
GO:0051412	response to corticosterone stimulus
GO:0042493	response to drug
GO:0010332	response to gamma radiation
GO:0033595	response to genistein
GO:0042542	response to hydrogen peroxide
GO:0017085	response to insecticide
GO:0033591	response to L-ascorbic acid
GO:0009651	response to salt stress
GO:0033197	response to vitamin E
GO:0014037	Schwann cell differentiation
GO:0008202	steroid metabolic process
GO:0016125	sterol metabolic process
GO:0042359	vitamin D metabolic process
GO:0006805	xenobiotic metabolic process

Cellular Component

GO:0030061	mitochondrial crista
GO:0005759	mitochondrial matrix
GO:0005739	mitochondrion
GO:0043204	perikaryon

Molecular Function

GO:0015485	cholesterol binding
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0005506	iron ion binding

cytochrome P450, family 11, subfamily A, polypeptide 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function