disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

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DAB2, DOC2, Disabled homolog 2, Differentially expressed protein 2, DOC-2

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:88.90 cerebellum:88.20 brain stem:- corpus callosum/glia:437.40 pineal gland:- peripheral nerve:368.10 spine:112.30 retina:237.30 eye:94 artery/aorta:569.50 vein:199.90 lymphnode:10.10 peripheral blood:200.40 spleen:226.90 thymus:77.30 bone marrow:137.80 adipose:121 bone:460.60 skin:369.60
GeneChip cerebrum:5.57 cerebellum:6.22 brain stem:5.77 corpus callosum/glia:5.69 pineal gland:- peripheral nerve:7.09 spine:6.26 retina:- eye:- artery/aorta:7.47 vein:7.77 lymphnode:7.80 peripheral blood:- spleen:8.04 thymus:6.86 bone marrow:6.47 adipose:8.43 bone:- skin:7.73
CAGE cerebrum:2.57 cerebellum:- brain stem:2.91 corpus callosum/glia:3.02 pineal gland:2.59 peripheral nerve:- spine:3.36 retina:- eye:- artery/aorta:4.28 vein:4.74 lymphnode:4.30 peripheral blood:- spleen:4.26 thymus:3.46 bone marrow:- adipose:5.24 bone:- skin:-
RNA-seq cerebrum:1.88 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.45 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:136.70 placenta:921.70 prostate:33.80 ovary:111.80 testis:47.60 heart:242.70 muscle:80.40 esophagus:- stomach:21.20 intestine:129.60 colon:50.90     liver/hepato:1235        lung:136.90    bladder:- kidney:509.50 pituitary:- thyroid/parathyroid:- adrenal gland:304.70 pancreas:88.90 breast:204.40 salivary:328.40
GeneChip uterus:7.99 placenta:10.99 prostate:6.62 ovary:7.82 testis:5.58 heart:7.30 muscle:6.25 esophagus:6.48 stomach:6.88 intestine:7.20 colon:6.97 liver/hepato:6.64 lung:8.19 bladder:- kidney:9.38 pituitary:5.84 thyroid/parathyroid:7.03 adrenal gland:9.64 pancreas:7.08 breast:7.85 salivary:7.10
CAGE uterus:4.22 placenta:6.20 prostate:3.93 ovary:3.82 testis:3.44 heart:4.06 muscle:3.15 esophagus:3.72 stomach:- intestine:3.27 colon:3.90     liver/hepato:2.75    lung:4.65 bladder:4.20 kidney:5.86 pituitary:2.42 thyroid/parathyroid:3.60 adrenal gland:- pancreas:3.71 breast:4.52 salivary:4.20
RNA-seq uterus:- placenta:- prostate:3.95 ovary:4.19 testis:4.15 heart:2.98 muscle:2.37 esophagus:- stomach:- intestine:- colon:3.94     liver/hepato:2.20        lung:4.87    bladder:- kidney:5.96 pituitary:- thyroid/parathyroid:3.67 adrenal gland:4.58 pancreas:- breast:4.78 salivary:-

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0006915  apoptosis
GO:0000904  cell morphogenesis involved in differentiation
GO:0008283  cell proliferation
GO:0048268  clathrin coat assembly
GO:0007492  endoderm development
GO:0007588  excretion
GO:0001701  in utero embryonic development
GO:0016044  membrane organization
GO:0030099  myeloid cell differentiation
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0032091  negative regulation of protein binding
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0006907  pinocytosis
GO:0030335  positive regulation of cell migration
GO:0045807  positive regulation of endocytosis
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0001921  positive regulation of receptor recycling
GO:0032968  positive regulation of RNA elongation from RNA polymerase II promoter
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0015031  protein transport
GO:0006898  receptor-mediated endocytosis
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0016324  apical plasma membrane
GO:0030132  clathrin coat of coated pit
GO:0030665  clathrin coated vesicle membrane
GO:0005905  coated pit
GO:0005765  lysosomal membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0070022  transforming growth factor beta receptor complex

Molecular Function

GO:0005178  integrin binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0046332  SMAD binding