disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

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Synonym

DAB2, DOC2, Disabled homolog 2, Differentially expressed protein 2, DOC-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:88.90 cerebellum:88.20 brain stem:- corpus callosum/glia:437.40 pineal gland:- peripheral nerve:368.10 spine:112.30 retina:237.30 eye:94 artery/aorta:569.50 vein:199.90 lymphnode:10.10 peripheral blood:200.40 spleen:226.90 thymus:77.30 bone marrow:137.80 adipose:121 bone:460.60 skin:369.60
GeneChip cerebrum:5.39 cerebellum:6.26 brain stem:5.55 corpus callosum/glia:5.43 pineal gland:- peripheral nerve:7.24 spine:6.27 retina:- eye:- artery/aorta:7.80 vein:8.24 lymphnode:8.08 peripheral blood:- spleen:8.58 thymus:7.15 bone marrow:6.38 adipose:8.57 bone:- skin:7.36
CAGE cerebrum:2.57 cerebellum:- brain stem:2.91 corpus callosum/glia:3.02 pineal gland:2.59 peripheral nerve:- spine:3.36 retina:- eye:- artery/aorta:4.28 vein:4.74 lymphnode:4.30 peripheral blood:- spleen:4.26 thymus:3.46 bone marrow:- adipose:5.24 bone:- skin:-
RNA-seq cerebrum:1.88 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.45 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:136.70 placenta:921.70 prostate:33.80 ovary:111.80 testis:47.60 heart:242.70 muscle:80.40 esophagus:- stomach:21.20 intestine:129.60 colon:50.90     liver/hepato:1235        lung:136.90    bladder:- kidney:509.50 pituitary:- thyroid/parathyroid:- adrenal gland:304.70 pancreas:88.90 breast:204.40 salivary:328.40
GeneChip uterus:8.23 placenta:10.95 prostate:6.68 ovary:8.12 testis:5.59 heart:7.43 muscle:6.18 esophagus:6.68 stomach:7.18 intestine:7.37 colon:7.57 liver/hepato:7.02 lung:8.62 bladder:- kidney:10 pituitary:5.44 thyroid/parathyroid:7.29 adrenal gland:9.76 pancreas:7.04 breast:8.26 salivary:7.30
CAGE uterus:4.22 placenta:6.20 prostate:3.93 ovary:3.82 testis:3.44 heart:4.06 muscle:3.15 esophagus:3.72 stomach:- intestine:3.27 colon:3.90     liver/hepato:2.75    lung:4.65 bladder:4.20 kidney:5.86 pituitary:2.42 thyroid/parathyroid:3.60 adrenal gland:- pancreas:3.71 breast:4.52 salivary:4.20
RNA-seq uterus:- placenta:- prostate:3.95 ovary:4.19 testis:4.15 heart:2.98 muscle:2.37 esophagus:- stomach:- intestine:- colon:3.94     liver/hepato:2.20        lung:4.87    bladder:- kidney:5.96 pituitary:- thyroid/parathyroid:3.67 adrenal gland:4.58 pancreas:- breast:4.78 salivary:-

Gene Information

IDs

Refseq ID NM_001343
Gene ID 1601
Unigene ID Hs.481980
Probe set ID 201280_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000153071
GTEx ID ENSG00000153071

Orthologous Gene

Mouse[12]  NM_001008702, NM_001037905, NM_001102400, NM_023118
Rat [0]  

Chromosomal Region

5p13.1  [39,371,780  -  39,462,402]

Gene Family (Interpro ID)

IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type

Link to Pubmed  (Pubmed ID)

8314147
8660969
8889548
9569023
9620555
10340382
10542228
10769163
11039902
11161789
11247302
11371563
11387212
11812785
11906161
11927540
11967127
12473651
12477932
12606711
12805222
12853125
12857860
12881709
14596919
14669280
15134832
15231748
15247260
15280374
15302935
15489334
15734730
15837803
15894542
16061224
16267015
16713569
16870701
16964243
16984970
17009406
17081983
17110338
17115114
17187061
17474147
17671122
18070591
18354201
18429820
18582465
19204726
19423540
19531213
19581412
19738201
19767570
19855435
19956625
20379614
20383146
20406964
20438785
20448150
20525238
20592473
20628624
20936779
21063401
21097498
21139048
21496867
21573318
21725366
21963094
21987572
21988832
21995445
22158540
22218591
22265793
22323290
22399289
22558309
22648170
22705885
22898784
22977233
23005040
23263486
23817569
23909735
24002585
24186266
24608456
24846918

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0006915  apoptosis
GO:0000904  cell morphogenesis involved in differentiation
GO:0008283  cell proliferation
GO:0048268  clathrin coat assembly
GO:0007492  endoderm development
GO:0007588  excretion
GO:0001701  in utero embryonic development
GO:0016044  membrane organization
GO:0030099  myeloid cell differentiation
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0032091  negative regulation of protein binding
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0006907  pinocytosis
GO:0030335  positive regulation of cell migration
GO:0045807  positive regulation of endocytosis
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0001921  positive regulation of receptor recycling
GO:0032968  positive regulation of RNA elongation from RNA polymerase II promoter
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0015031  protein transport
GO:0006898  receptor-mediated endocytosis
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0016324  apical plasma membrane
GO:0030132  clathrin coat of coated pit
GO:0030665  clathrin coated vesicle membrane
GO:0005905  coated pit
GO:0005765  lysosomal membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0070022  transforming growth factor beta receptor complex

Molecular Function

GO:0005178  integrin binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0046332  SMAD binding