aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

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Synonym

C9, High-affinity hepatic bile acid-binding protein, 2-ALPHA-HSD, 20-alpha-hydroxysteroid dehydrogenase, MBAB, HBAB, H-37, DDH1, HAKRC, Dihydrodiol dehydrogenase 1/2, Chlordecone reductase homolog HAKRC, DD1, DD1/DD2, MGC8954, Aldo-keto reductase family 1 member C1, 20-ALPHA-HSD, DDH, AKR1C1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:68.70 cerebellum:75.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:82.30 artery/aorta:119.90 vein:- lymphnode:- peripheral blood:- spleen:- thymus:38.70 bone marrow:- adipose:161.30 bone:51.20 skin:91.20
GeneChip cerebrum:7.57 cerebellum:6.90 brain stem:7.88 corpus callosum/glia:7.09 pineal gland:- peripheral nerve:9.58 spine:8.50 retina:- eye:- artery/aorta:9.58 vein:9.51 lymphnode:7.69 peripheral blood:- spleen:6.44 thymus:6.93 bone marrow:7.15 adipose:10.78 bone:- skin:9.53
CAGE cerebrum:2.34 cerebellum:- brain stem:3.01 corpus callosum/glia:2.41 pineal gland:2.24 peripheral nerve:- spine:3.49 retina:- eye:- artery/aorta:3.74 vein:3.86 lymphnode:2.69 peripheral blood:- spleen:0.92 thymus:0.33 bone marrow:- adipose:5.31 bone:- skin:-
RNA-seq cerebrum:2.16 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.96 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.31 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:7.30 prostate:- ovary:37.30 testis:138.40 heart:25.50 muscle:180.80 esophagus:- stomach:127.50 intestine:32.40 colon:33.90     liver/hepato:316.70        lung:219.90    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:71.10 breast:37.20 salivary:656.80
GeneChip uterus:7.09 placenta:6.14 prostate:7.26 ovary:7.03 testis:7.92 heart:8.55 muscle:8.47 esophagus:9.74 stomach:8.90 intestine:8.52 colon:7.98 liver/hepato:10.97 lung:8.81 bladder:- kidney:8.39 pituitary:7.09 thyroid/parathyroid:7.93 adrenal gland:7.58 pancreas:7.77 breast:8.80 salivary:7.14
CAGE uterus:1.93 placenta:0.16 prostate:3.04 ovary:2.69 testis:3.23 heart:3.80 muscle:3.08 esophagus:4.27 stomach:- intestine:2.89 colon:2.35     liver/hepato:5.99    lung:3.98 bladder:3.48 kidney:4.76 pituitary:2.74 thyroid/parathyroid:3.71 adrenal gland:- pancreas:2.81 breast:4.95 salivary:2.17
RNA-seq uterus:- placenta:- prostate:5.08 ovary:3.82 testis:5.09 heart:3.79 muscle:3.11 esophagus:- stomach:- intestine:- colon:3.69     liver/hepato:8.04        lung:4.88    bladder:- kidney:5.52 pituitary:- thyroid/parathyroid:6.00 adrenal gland:5.00 pancreas:- breast:8.53 salivary:-

Gene Information

IDs

Refseq ID NM_001353
Gene ID 1645
Unigene ID Hs.460260
Probe set ID 204151_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000187134
GTEx ID ENSG00000187134

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

10p15.1  [4,934,796  -  5,022,159]

Gene Family (Interpro ID)

IPR001395  Aldo/keto reductase
IPR020471  Aldo/keto reductase subgroup

Link to Pubmed  (Pubmed ID)

7515059
7626489
7789999
8011662
8132567
8172617
8274401
8486699
8573067
10510318
10672042
11013348
11514561
11956619
12477932
12579257
12733716
12899831
13678667
15164054
15212687
15489334
15492289
15494612
16079077
16338060
16361083
16385451
16543247
16712791
17149600
17618725
17697149
17945194
18624398
18654764
18984031
19218247
19320734
19423521
19442656
19487289
19696165
19738201
19846565
20201926
20673851
20689807
20727920
21217827
21232532
21521174
21900206
22064385
22278827
22566634
23165153
23183084
23933386
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0015721  bile acid and bile salt transport
GO:0008206  bile acid metabolic process
GO:0071395  cellular response to jasmonic acid stimulus
GO:0042632  cholesterol homeostasis
GO:0007586  digestion
GO:0030299  intestinal cholesterol absorption
GO:0055114  oxidation reduction
GO:0007603  phototransduction, visible light
GO:0042448  progesterone metabolic process
GO:0051260  protein homooligomerization
GO:0046683  response to organophosphorus
GO:0042574  retinal metabolic process
GO:0001523  retinoid metabolic process
GO:0006805  xenobiotic metabolic process

Cellular Component

GO:0005829  cytosol

Molecular Function

GO:0047006  20-alpha-hydroxysteroid dehydrogenase activity
GO:0047042  3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
GO:0004032  aldehyde reductase activity
GO:0004033  aldo-keto reductase activity
GO:0032052  bile acid binding
GO:0031406  carboxylic acid binding
GO:0047718  indanol dehydrogenase activity
GO:0047086  ketosteroid monooxygenase activity
GO:0016655  oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
GO:0018636  phenanthrene 9,10-monooxygenase activity
GO:0047115  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity