DNA-damage-inducible transcript 3

Synonym

CEBPZ, DNA-damage-inducible transcript 3, DDIT3, C/EBP-homologous protein, CHOP10, CHOP, GADD153, DNA damage-inducible transcript 3, MGC4154, C/EBP zeta, DDIT-3

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:7.26

cerebellum:7.21

brain stem:7.68

corpus callosum/glia:7.22

pineal gland:-

peripheral nerve:7.39

spine:7.52

retina:-

eye:-

artery/aorta:7.44

vein:8.63

lymphnode:6.84

peripheral blood:-

spleen:6.58

thymus:6.42

bone marrow:7.17

adipose:7.40

bone:-

skin:7.08

CAGE

cerebrum:3.38

cerebellum:-

brain stem:4.00

corpus callosum/glia:3.66

pineal gland:3.96

peripheral nerve:-

spine:3.63

retina:-

eye:-

artery/aorta:3.81

vein:3.18

lymphnode:2.30

peripheral blood:-

spleen:2.52

thymus:1.75

bone marrow:-

adipose:3.61

bone:-

skin:-

RNA-seq

cerebrum:4.99

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.02

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.68

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:7.11

placenta:7.30

prostate:7.28

ovary:7.14

testis:7.33

heart:7.52

muscle:7.46

esophagus:6.91

stomach:7.09

intestine:6.81

colon:6.80

liver/hepato:7.21

lung:7.15

bladder:-

kidney:7.44

pituitary:7.49

thyroid/parathyroid:7.60

adrenal gland:7.48

pancreas:7.02

breast:7.15

salivary:6.91

CAGE

uterus:3.44

placenta:3.06

prostate:3.83

ovary:3.71

testis:3.04

heart:3.07

muscle:2.93

esophagus:3.24

stomach:-

intestine:3.04

colon:2.74

liver/hepato:3.01

lung:3.21

bladder:4.03

kidney:3.36

pituitary:3.04

thyroid/parathyroid:4.76

adrenal gland:-

pancreas:2.48

breast:3.73

salivary:3.45

RNA-seq

uterus:-

placenta:-

prostate:4.93

ovary:4.81

testis:4.59

heart:1.88

muscle:3.78

esophagus:-

stomach:-

intestine:-

colon:4.25

liver/hepato:3.05

lung:4.90

bladder:-

kidney:4.70

pituitary:-

thyroid/parathyroid:5.47

adrenal gland:2.78

pancreas:-

breast:3.85

salivary:-

IDs

Refseq ID	NM_004083
Gene ID	1649
Unigene ID	-
Probe set ID	209383_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000175197
GTEx ID	ENSG00000175197

Orthologous Gene

Mouse[1]	NM_007837
Rat[2]	NM_001109986, NM_024134

Chromosomal Region

12q13.3 [57,910,371 - 57,914,300]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR004827

Basic-leucine zipper (bZIP) transcription factor

Gene Ontology (GO ID)

Biological Process

GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0070059	apoptosis in response to endoplasmic reticulum stress
GO:0007050	cell cycle arrest
GO:0045454	cell redox homeostasis
GO:0044267	cellular protein metabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043433	negative regulation of transcription factor activity
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0090090	negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0032757	positive regulation of interleukin-8 production
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
GO:0043620	regulation of transcription in response to stress
GO:0006355	regulation of transcription, DNA-dependent
GO:0006974	response to DNA damage stimulus
GO:0034976	response to endoplasmic reticulum stress
GO:0006986	response to unfolded protein
GO:0016055	Wnt receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0003677	DNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0003714	transcription corepressor activity
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding

DNA-damage-inducible transcript 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function