DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

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Synonym

Helicase-like protein 2, HLP2, ATP-dependent RNA helicase DDX3X, DDX3X, DEAD box, X isoform, DDX3, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked, DBX, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, DDX14, DEAD box protein 3, X-chromosomal

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.05 cerebellum:6.04 brain stem:5.96 corpus callosum/glia:6.20 pineal gland:- peripheral nerve:5.60 spine:6.34 retina:- eye:- artery/aorta:5.81 vein:6.02 lymphnode:5.90 peripheral blood:- spleen:6.36 thymus:7.92 bone marrow:6.48 adipose:6.04 bone:- skin:5.80
CAGE cerebrum:5.16 cerebellum:- brain stem:5.31 corpus callosum/glia:5.20 pineal gland:5.23 peripheral nerve:- spine:5.59 retina:- eye:- artery/aorta:5.12 vein:4.93 lymphnode:5.07 peripheral blood:- spleen:5.42 thymus:5.33 bone marrow:- adipose:6.03 bone:- skin:-
RNA-seq cerebrum:5.16 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.32 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.26 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.36 placenta:7.29 prostate:6.07 ovary:6.64 testis:7.71 heart:6.18 muscle:5.98 esophagus:6.41 stomach:6.12 intestine:6.37 colon:6.03 liver/hepato:5.86 lung:6.07 bladder:- kidney:5.73 pituitary:6.10 thyroid/parathyroid:5.81 adrenal gland:5.97 pancreas:6.38 breast:5.63 salivary:5.61
CAGE uterus:5.66 placenta:5.90 prostate:5.08 ovary:5.49 testis:4.85 heart:5.16 muscle:5.26 esophagus:5.58 stomach:- intestine:5.57 colon:5.04     liver/hepato:5.79    lung:5.16 bladder:5.64 kidney:5.59 pituitary:5.82 thyroid/parathyroid:5.36 adrenal gland:- pancreas:4.65 breast:5.36 salivary:5.26
RNA-seq uterus:- placenta:- prostate:5.11 ovary:5.46 testis:5.11 heart:5.11 muscle:5.47 esophagus:- stomach:- intestine:- colon:5.58     liver/hepato:4.27        lung:5.26    bladder:- kidney:5.31 pituitary:- thyroid/parathyroid:5.90 adrenal gland:5.40 pancreas:- breast:5.89 salivary:-

Gene Information

IDs

Refseq ID NM_001356
Gene ID 1654
Unigene ID -
Probe set ID 201211_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000215301
GTEx ID ENSG00000215301

Orthologous Gene

Mouse[8]  NM_010028, NM_033077
Rat[1]  NM_001108858, NM_001108246

Chromosomal Region

Xp11.4  [41,192,651  -  41,223,725]

Gene Family (Interpro ID)

IPR014001  DEAD-like helicase, N-terminal
IPR014021  Helicase, superfamily 1/2, ATP-binding domain

Link to Pubmed  (Pubmed ID)

9381176
9730595
10329544
10336476
10859333
11256614
11710523
12477932
14559993
14729942
14743216
15047060
15161933
15231748
15489334
15507209
15516266
15588285
15592455
15998806
16055720
16094384
16097034
16159877
16301996
16341674
16354571
16712791
16818630
17108031
17353931
17357160
17361185
17620599
17631897
17661632
17667941
17696464
17855521
18029348
18187620
18259889
18264132
18377426
18508616
18583960
18596238
18628297
18632687
18636090
18729074
18845156
18846110
18976975
19056867
19135240
19149558
19322201
19380743
19394292
19454010
19738201
19782656
19793905
19805454
20018238
20020773
20080577
20127681
20308691
20508642
20657822
20811636
20837705
20862261
21080425
21081666
21139048
21145461
21170385
21182205
21237216
21252943
21319273
21358275
21360055
21428961
21448281
21549307
21575865
21589879
21726808
21730191
21853274
21883093
21890473
21906983
21942715
21963094
21987572
22053931
22113938
22145905
22174317
22178446
22210892
22268729
22270009
22412018
22492871
22505724
22623428
22797925
22810585
22863883
22872150
22939629
23000965
23084401
23125841
23151878
23330003
23402259
23413191
23438482
23463506
23478265
23527197
23584477
23608157
23673860
23754689
23840900
23862649
23974721
24183723
24244333
24250222
24332808
24418539
24457600
24583282
24639526
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0071243  cellular response to arsenic
GO:0071470  cellular response to osmotic stress
GO:0007059  chromosome segregation
GO:0008625  induction of apoptosis via death domain receptors
GO:0045087  innate immune response
GO:0042256  mature ribosome assembly
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0030308  negative regulation of cell growth
GO:0031333  negative regulation of protein complex assembly
GO:0017148  negative regulation of translation
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0030307  positive regulation of cell growth
GO:0032728  positive regulation of interferon-beta production
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045727  positive regulation of translation
GO:0045948  positive regulation of translational initiation
GO:0007243  protein kinase cascade
GO:0009615  response to virus
GO:0010501  RNA secondary structure unwinding
GO:0034063  stress granule assembly
GO:0006351  transcription, DNA-dependent
GO:0019048  virus-host interaction

Cellular Component

GO:0005737  cytoplasm
GO:0022627  cytosolic small ribosomal subunit
GO:0005852  eukaryotic translation initiation factor 3 complex
GO:0005741  mitochondrial outer membrane
GO:0016607  nuclear speck
GO:0005634  nucleus
GO:0010494  stress granule

Molecular Function

GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0004004  ATP-dependent RNA helicase activity
GO:0016887  ATPase activity
GO:0003677  DNA binding
GO:0008190  eukaryotic initiation factor 4E binding
GO:0048027  mRNA 5'-UTR binding
GO:0008143  poly(A) RNA binding
GO:0005515  protein binding
GO:0043024  ribosomal small subunit binding
GO:0003723  RNA binding
GO:0008134  transcription factor binding
GO:0031369  translation initiation factor binding