complement factor D (adipsin)

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Synonym

DF, complement factor D (adipsin), C3 convertase activator, CFD, ADN, PFD, Adipsin, Properdin factor D, D component of complement (adipsin), Complement factor D precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:58.80 artery/aorta:30 vein:- lymphnode:- peripheral blood:36.40 spleen:56.70 thymus:12.90 bone marrow:39.40 adipose:887.30 bone:76.80 skin:38.40
GeneChip cerebrum:5.37 cerebellum:4.93 brain stem:5.49 corpus callosum/glia:5.71 pineal gland:- peripheral nerve:8.55 spine:5.50 retina:- eye:- artery/aorta:11.48 vein:11.75 lymphnode:8.04 peripheral blood:- spleen:6.40 thymus:9.09 bone marrow:8.93 adipose:12.43 bone:- skin:11.24
CAGE cerebrum:1.10 cerebellum:- brain stem:1.57 corpus callosum/glia:2.08 pineal gland:1.22 peripheral nerve:- spine:1.93 retina:- eye:- artery/aorta:5.99 vein:6.69 lymphnode:4.35 peripheral blood:- spleen:3.65 thymus:2.45 bone marrow:- adipose:7.21 bone:- skin:-
RNA-seq cerebrum:0.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:6.31 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:7.41 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:264.30 placenta:72.90 prostate:259.10 ovary:74.50 testis:51.90 heart:- muscle:180.80 esophagus:- stomach:42.50 intestine:97.20 colon:84.80     liver/hepato:21.10        lung:63.50    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:80 breast:46.50 salivary:-
GeneChip uterus:8.40 placenta:9.45 prostate:8.75 ovary:7.77 testis:8.63 heart:11.18 muscle:10.02 esophagus:10.74 stomach:10.76 intestine:10.33 colon:11.27 liver/hepato:5.84 lung:10.69 bladder:- kidney:6.24 pituitary:5.57 thyroid/parathyroid:10.39 adrenal gland:8.40 pancreas:8.50 breast:11.06 salivary:9.27
CAGE uterus:5.39 placenta:5.24 prostate:6.98 ovary:4.95 testis:5.42 heart:6.75 muscle:5.86 esophagus:6.28 stomach:- intestine:5.07 colon:5.98     liver/hepato:3.12    lung:5.87 bladder:6.73 kidney:3.15 pituitary:1.04 thyroid/parathyroid:6.19 adrenal gland:- pancreas:4.06 breast:6.90 salivary:5.35
RNA-seq uterus:- placenta:- prostate:8.32 ovary:3.07 testis:6.38 heart:5.80 muscle:4.74 esophagus:- stomach:- intestine:- colon:7.53     liver/hepato:1.86        lung:7.65    bladder:- kidney:2.30 pituitary:- thyroid/parathyroid:5.85 adrenal gland:5.43 pancreas:- breast:8.33 salivary:-

Gene Information

IDs

Refseq ID NM_001928
Gene ID 1675
Unigene ID Hs.155597
Probe set ID 205382_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000197766
GTEx ID ENSG00000197766

Orthologous Gene

Mouse[1]  NM_013459
Rat[1]  NM_001077642

Chromosomal Region

19p13.3  [859,665  -  863,606]
LRG_46  [5,001  -  8,960]

Gene Family (Interpro ID)

IPR001254  Peptidase S1/S6, chymotrypsin/Hap
IPR001314  Peptidase S1A, chymotrypsin
IPR009003  Serine/cysteine peptidase, trypsin-like

Link to Pubmed  (Pubmed ID)

162484
824769
1374388
2023254
6363133
6383466
6459901
6776531
6821372
6987665
7592653
8289289
9145127
10971122
12080056
12477932
15174051
16169070
19056867
19336475
19344414
19538214
19699327
19913121
20628086
21139680
21205667
21612582
21890473
21906983
21963094
22003108
22362762
22930722
23956345

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0006956  complement activation
GO:0006957  complement activation, alternative pathway
GO:0045087  innate immune response
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0006508  proteolysis

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0004252  serine-type endopeptidase activity
GO:0008236  serine-type peptidase activity