additional sex combs like 1 (Drosophila)

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Synonym

MGC117280, Additional sex combs-like protein 1, ASXL1, additional sex combs like 1 (Drosophila), Putative Polycomb group protein ASXL1, MGC71111, KIAA0978

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:53.30 cerebellum:100.80 brain stem:- corpus callosum/glia:116.60 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:94 artery/aorta:- vein:- lymphnode:171.90 peripheral blood:- spleen:75.60 thymus:116 bone marrow:157.40 adipose:40.30 bone:76.80 skin:67.20
GeneChip cerebrum:6.52 cerebellum:6.87 brain stem:6.50 corpus callosum/glia:6.77 pineal gland:- peripheral nerve:6.88 spine:6.34 retina:- eye:- artery/aorta:6.98 vein:6.89 lymphnode:7 peripheral blood:- spleen:6.92 thymus:7.14 bone marrow:6.71 adipose:6.80 bone:- skin:6.61
CAGE cerebrum:3.76 cerebellum:- brain stem:3.72 corpus callosum/glia:3.92 pineal gland:3.60 peripheral nerve:- spine:3.86 retina:- eye:- artery/aorta:4.00 vein:4.47 lymphnode:4.05 peripheral blood:- spleen:4.27 thymus:4.67 bone marrow:- adipose:4.21 bone:- skin:-
RNA-seq cerebrum:2.56 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.45 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:145.80 placenta:10.90 prostate:56.30 ovary:223.60 testis:112.50 heart:51.10 muscle:40.20 esophagus:- stomach:63.70 intestine:97.20 colon:59.40     liver/hepato:137.20        lung:97.80    bladder:125.60 kidney:124.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:80 breast:46.50 salivary:-
GeneChip uterus:7.07 placenta:5.97 prostate:6.92 ovary:7.30 testis:6.65 heart:6.47 muscle:6.75 esophagus:6.41 stomach:6.71 intestine:6.55 colon:6.60 liver/hepato:6.76 lung:6.87 bladder:- kidney:6.83 pituitary:6.60 thyroid/parathyroid:6.84 adrenal gland:6.94 pancreas:6.40 breast:7.13 salivary:5.99
CAGE uterus:4.56 placenta:3.52 prostate:4.11 ovary:4.30 testis:4.05 heart:4.03 muscle:3.84 esophagus:3.61 stomach:- intestine:3.56 colon:4.08     liver/hepato:3.71    lung:4.28 bladder:4.17 kidney:3.74 pituitary:3.91 thyroid/parathyroid:4.08 adrenal gland:- pancreas:3.92 breast:4.19 salivary:3.81
RNA-seq uterus:- placenta:- prostate:3.43 ovary:3.67 testis:3.82 heart:2.39 muscle:3.23 esophagus:- stomach:- intestine:- colon:3.04     liver/hepato:2.23        lung:3.70    bladder:- kidney:3.05 pituitary:- thyroid/parathyroid:3.52 adrenal gland:4.21 pancreas:- breast:3.13 salivary:-

Gene Information

IDs

Refseq ID NM_015338
Gene ID 171023
Unigene ID Hs.374043
Probe set ID 212234_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000171456
GTEx ID ENSG00000171456

Orthologous Gene

Mouse[2]  NM_001039939
Rat[2]  NM_001039939

Chromosomal Region

20q11.21  [30,946,147  -  31,027,122]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1349871
8889548
9477319
10231032
11780052
12168954
12477932
12657473
14702039
15489334
16606617
17474147
18239623
18258596
18506748
18624398
18957548
19388938
19586940
19609284
19615732
19815555
19865112
19880879
20182461
20334914
20360068
20408841
20410925
20436459
20596031
20678218
20693432
20805357
20880116
21139048
21307773
21346257
21455215
21576631
21642991
21706002
21712540
21832049
21890473
21904853
21906983
21923651
21963094
21987572
21988832
22031865
22058207
22271902
22419483
22436456
22489043
22505724
22535592
22542624
22897849
22905207
22915647
22929312
23000965
23009937
23018865
23065512
23099237
23294243
23365461
23531518
23602568
23690417
23704076
24115220
24216483
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0060348  bone development
GO:0045599  negative regulation of fat cell differentiation
GO:0048387  negative regulation of retinoic acid receptor signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0048386  positive regulation of retinoic acid receptor signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032526  response to retinoic acid
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000790  nuclear chromatin

Molecular Function

GO:0003677  DNA binding
GO:0046872  metal ion binding
GO:0042975  peroxisome proliferator activated receptor binding
GO:0005515  protein binding
GO:0042974  retinoic acid receptor binding
GO:0003713  transcription coactivator activity
GO:0003714  transcription corepressor activity