24-dehydrocholesterol reductase

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Synonym

24-dehydrocholesterol reductase, Nbla03646, DHCR24, Seladin-1, seladin-1, SELADIN1, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, 24-dehydrocholesterol reductase precursor, KIAA0018

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:279.70 cerebellum:239.30 brain stem:- corpus callosum/glia:116.60 pineal gland:- peripheral nerve:276 spine:336.90 retina:118.60 eye:170.40 artery/aorta:89.90 vein:866.40 lymphnode:80.90 peripheral blood:127.50 spleen:245.80 thymus:25.80 bone marrow:59 adipose:80.70 bone:64 skin:240
GeneChip cerebrum:8.50 cerebellum:7.96 brain stem:9.18 corpus callosum/glia:9.10 pineal gland:- peripheral nerve:8.98 spine:10.27 retina:- eye:- artery/aorta:7.09 vein:6.10 lymphnode:7.45 peripheral blood:- spleen:8.89 thymus:5.99 bone marrow:5.75 adipose:7.81 bone:- skin:9.04
CAGE cerebrum:4.15 cerebellum:- brain stem:5.49 corpus callosum/glia:5.55 pineal gland:2.28 peripheral nerve:- spine:5.47 retina:- eye:- artery/aorta:3.46 vein:2.56 lymphnode:3.50 peripheral blood:- spleen:4.35 thymus:2.34 bone marrow:- adipose:3.56 bone:- skin:-
RNA-seq cerebrum:5.63 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.18 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:87.40 prostate:135.20 ovary:149.10 testis:207.70 heart:204.30 muscle:20.10 esophagus:- stomach:63.70 intestine:97.20 colon:118.70     liver/hepato:200.60        lung:293.30    bladder:125.60 kidney:311.90 pituitary:- thyroid/parathyroid:- adrenal gland:1929.90 pancreas:53.30 breast:399.60 salivary:-
GeneChip uterus:6.35 placenta:6.94 prostate:9.73 ovary:8.12 testis:7.91 heart:6.78 muscle:8.02 esophagus:9.40 stomach:7.91 intestine:7.67 colon:7.52 liver/hepato:9.97 lung:8.74 bladder:- kidney:7.28 pituitary:5.99 thyroid/parathyroid:6.37 adrenal gland:11.67 pancreas:6.37 breast:8.70 salivary:7.21
CAGE uterus:2.88 placenta:3.15 prostate:3.61 ovary:3.82 testis:4.36 heart:2.39 muscle:4.48 esophagus:5.23 stomach:- intestine:3.68 colon:3.42     liver/hepato:6.19    lung:5.39 bladder:2.65 kidney:3.44 pituitary:2.00 thyroid/parathyroid:3.21 adrenal gland:- pancreas:3.16 breast:4.39 salivary:3.32
RNA-seq uterus:- placenta:- prostate:3.71 ovary:5.29 testis:4.76 heart:1.53 muscle:5.22 esophagus:- stomach:- intestine:- colon:2.75     liver/hepato:8.01        lung:6.14    bladder:- kidney:4.36 pituitary:- thyroid/parathyroid:4.45 adrenal gland:3.55 pancreas:- breast:5.79 salivary:-

Gene Information

IDs

Refseq ID NM_014762
Gene ID 1718
Unigene ID Hs.498727
Probe set ID 200862_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000116133
GTEx ID ENSG00000116133

Orthologous Gene

Mouse[3]  NM_053272
Rat[1]  NM_001080148

Chromosomal Region

1p32.3  [55,315,300  -  55,352,921]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

4359325
7584026
7584028
11007892
11519011
12457401
12477932
15001630
15342556
15489334
15577914
15688385
15954227
16407971
16762343
17510943
17579359
17855807
17984220
18194465
18499757
18660489
18762779
18815215
19325144
19336370
19520779
19815556
19861417
19946888
20061631
20166102
20465827
20568014
20634891
20689807
21139048
21559050
21890473
21901424
21906983
21963094
21987572
21987590
22010141
22178193
22190034
22431021
22910610
23000965
23050906
23123430
23246001
23416078
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0042987  amyloid precursor protein catabolic process
GO:0006915  apoptosis
GO:0007050  cell cycle arrest
GO:0006695  cholesterol biosynthetic process
GO:0030539  male genitalia development
GO:0016044  membrane organization
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0008285  negative regulation of cell proliferation
GO:0031639  plasminogen activation
GO:0008104  protein localization
GO:0007265  Ras protein signal transduction
GO:0009725  response to hormone stimulus
GO:0006979  response to oxidative stress
GO:0043588  skin development
GO:0009888  tissue development

Cellular Component

GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0005634  nucleus

Molecular Function

GO:0050614  delta24-sterol reductase activity
GO:0019899  enzyme binding
GO:0050660  FAD binding
GO:0016628  oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0042605  peptide antigen binding
GO:0008762  UDP-N-acetylmuramate dehydrogenase activity