dystrophia myotonica-protein kinase

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Synonym

Myotonic dystrophy protein kinase, DMPK, DM-kinase, MDPK, DMK, Myotonin-protein kinase, DM1PK, DM, MT-PK, dystrophia myotonica-protein kinase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.70 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:153.40 spine:- retina:- eye:58.80 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:- spleen:37.80 thymus:- bone marrow:- adipose:- bone:- skin:24
GeneChip cerebrum:6.66 cerebellum:7.02 brain stem:6.45 corpus callosum/glia:6.97 pineal gland:- peripheral nerve:6.58 spine:6.70 retina:- eye:- artery/aorta:7.56 vein:7.62 lymphnode:6.76 peripheral blood:- spleen:6.69 thymus:6.26 bone marrow:6.37 adipose:6.84 bone:- skin:6.57
CAGE cerebrum:1.44 cerebellum:- brain stem:1.64 corpus callosum/glia:1.70 pineal gland:1.46 peripheral nerve:- spine:1.74 retina:- eye:- artery/aorta:3.93 vein:1.92 lymphnode:1.04 peripheral blood:- spleen:0.95 thymus:0.06 bone marrow:- adipose:2.28 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.68 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:32.80 prostate:78.90 ovary:111.80 testis:51.90 heart:63.90 muscle:40.20 esophagus:- stomach:21.20 intestine:64.80 colon:59.40     liver/hepato:21.10        lung:29.30    bladder:- kidney:72.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:7.03 placenta:6.49 prostate:6.39 ovary:6.56 testis:6.45 heart:7.20 muscle:7.01 esophagus:7.33 stomach:7.03 intestine:6.98 colon:6.74 liver/hepato:6.21 lung:7 bladder:- kidney:6.82 pituitary:7.11 thyroid/parathyroid:6.79 adrenal gland:7.41 pancreas:6.68 breast:7 salivary:6.45
CAGE uterus:3.15 placenta:1.50 prostate:3.01 ovary:2.31 testis:1.39 heart:3.82 muscle:4.24 esophagus:3.62 stomach:- intestine:2.63 colon:3.26     liver/hepato:0.71    lung:1.98 bladder:3.99 kidney:1.55 pituitary:1.36 thyroid/parathyroid:1.73 adrenal gland:- pancreas:3.57 breast:1.80 salivary:1.39
RNA-seq uterus:- placenta:- prostate:0.75 ovary:1.13 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:1.06    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:1.49 pancreas:- breast:0.47 salivary:-

Gene Information

IDs

Refseq ID NM_001081560
Gene ID 1760
Unigene ID Hs.631596
Probe set ID 217066_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000104936
GTEx ID ENSG00000104936

Orthologous Gene

Mouse[2]  NM_001190490, NM_001190491, NM_032418
Rat[2]  NM_001190490, NM_001190491, NM_032418

Chromosomal Region

19q13.32  [46,272,978  -  46,285,815]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1302022
1303233
1310900
1546325
1546326
2037285
7488138
7905855
8076686
8281152
8288237
8401505
8469976
8499920
8595416
9371827
9490724
9811941
9872056
9949207
10026240
10400997
10601309
10625651
10811636
10869570
10913253
11121205
11287000
11527424
11555624
11592825
11748308
11752456
11766468
11768386
11768387
11781699
11793472
11903110
11903304
11931630
12220642
12427866
12477932
12598332
12600888
12697816
12832055
14510658
14607980
14657503
14701736
14759258
15017064
15039975
15079005
15210527
15284213
15317754
15462191
15476170
15583383
15598648
15684391
15722335
15824798
15894391
15981568
16099181
16169070
16193250
16285929
16519679
16636244
16713569
16946708
17192963
17204048
17433680
17825047
17846170
18029348
18184345
18228241
18474935
18574937
18577525
18611984
18648326
18729234
18798829
19127114
19166838
19309729
19514047
19626675
19913121
19946639
19948975
20228473
20231114
20301344
20346670
20421627
20628086
20635151
20644219
20685272
20801043
20843780
21204525
21760538
21900206
21906983
21949239
21963094
21988832
22354993
22939624
23196502
23209425
23263591
23680132
23933738
24136222
24639526
24722188

Gene Ontology  (GO ID)

Biological Process

GO:0006874  cellular calcium ion homeostasis
GO:0010657  muscle cell apoptosis
GO:0006998  nuclear envelope organization
GO:0006468  protein amino acid phosphorylation
GO:0014853  regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
GO:0008016  regulation of heart contraction
GO:0010830  regulation of myotube differentiation
GO:0014722  regulation of skeletal muscle contraction by calcium ion signaling
GO:0002028  regulation of sodium ion transport
GO:0051823  regulation of synapse structural plasticity

Cellular Component

GO:0005829  cytosol
GO:0005789  endoplasmic reticulum membrane
GO:0031307  integral to mitochondrial outer membrane
GO:0031965  nuclear membrane
GO:0005640  nuclear outer membrane
GO:0005886  plasma membrane
GO:0033017  sarcoplasmic reticulum membrane

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0017020  myosin phosphatase regulator activity
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity