dihydropyrimidine dehydrogenase

Synonym

Dihydropyrimidine dehydrogenase [NADP+] precursor, MGC132008, Dihydrouracil dehydrogenase, DHPDHase, DPD, dihydropyrimidine dehydrogenase, DHP, Dihydrothymine dehydrogenase, MGC70799, DPYD

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:39.10

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:148.30

peripheral nerve:92

spine:449.20

retina:-

eye:82.30

artery/aorta:89.90

vein:-

lymphnode:70.80

peripheral blood:54.70

spleen:94.50

thymus:64.40

bone marrow:255.80

adipose:80.70

bone:89.60

skin:100.80

GeneChip

cerebrum:4.28

cerebellum:3.34

brain stem:4.67

corpus callosum/glia:5.12

pineal gland:-

peripheral nerve:5.95

spine:5.03

retina:-

eye:-

artery/aorta:6.28

vein:5.61

lymphnode:6.14

peripheral blood:-

spleen:6.96

thymus:6.92

bone marrow:6.54

adipose:6.94

bone:-

skin:6

CAGE

cerebrum:3.61

cerebellum:-

brain stem:4.56

corpus callosum/glia:4.62

pineal gland:3.18

peripheral nerve:-

spine:4.56

retina:-

eye:-

artery/aorta:3.77

vein:4.13

lymphnode:4.40

peripheral blood:-

spleen:4.88

thymus:4.69

bone marrow:-

adipose:4.80

bone:-

skin:-

RNA-seq

cerebrum:1.50

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.04

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.86

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:82

placenta:58.30

prostate:146.40

ovary:37.30

testis:21.60

heart:12.80

muscle:-

esophagus:-

stomach:42.50

intestine:97.20

colon:59.40

liver/hepato:73.90

lung:58.70

bladder:-

kidney:41.60

pituitary:232

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:44.50

breast:46.50

salivary:-

GeneChip

uterus:6.52

placenta:5.47

prostate:6.35

ovary:6.91

testis:4.05

heart:6.08

muscle:4.96

esophagus:5.81

stomach:5.86

intestine:6.11

colon:5.29

liver/hepato:8.16

lung:7.30

bladder:-

kidney:5.30

pituitary:5.59

thyroid/parathyroid:6.21

adrenal gland:6.69

pancreas:5.26

breast:6.37

salivary:6.41

CAGE

uterus:4.38

placenta:3.69

prostate:4.13

ovary:4.10

testis:3.34

heart:3.93

muscle:3.33

esophagus:4.13

stomach:-

intestine:4.66

colon:3.83

liver/hepato:4.37

lung:4.79

bladder:4.16

kidney:3.47

pituitary:4.20

thyroid/parathyroid:3.94

adrenal gland:-

pancreas:3.34

breast:4.25

salivary:3.96

RNA-seq

uterus:-

placenta:-

prostate:4.06

ovary:3.94

testis:3.11

heart:2.43

muscle:2.13

esophagus:-

stomach:-

intestine:-

colon:4.14

liver/hepato:3.97

lung:4.07

bladder:-

kidney:3.17

pituitary:-

thyroid/parathyroid:2.83

adrenal gland:3.06

pancreas:-

breast:3.31

salivary:-

IDs

Refseq ID	NM_000110
Gene ID	1806
Unigene ID	Hs.335034
Probe set ID	204646_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000188641
GTEx ID	ENSG00000188641

Orthologous Gene

Mouse[2]	NM_170778
Rat[2]	NM_170778

Chromosomal Region

1p21.3 [97,543,299 - 98,386,605]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR013027

FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Gene Ontology (GO ID)

Biological Process

GO:0019483	beta-alanine biosynthetic process
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
GO:0006145	purine base catabolic process
GO:0006208	pyrimidine base catabolic process
GO:0006206	pyrimidine base metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0006214	thymidine catabolic process
GO:0006210	thymine catabolic process
GO:0006222	UMP biosynthetic process
GO:0006212	uracil catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Molecular Function

GO:0051539	4 iron, 4 sulfur cluster binding
GO:0004158	dihydroorotate oxidase activity
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
GO:0050660	FAD binding
GO:0046872	metal ion binding
GO:0050661	NADP or NADPH binding
GO:0042803	protein homodimerization activity

dihydropyrimidine dehydrogenase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function