heparin-binding EGF-like growth factor

Synonym

HB-EGF, heparin-binding EGF-like growth factor, HEGFL, Diphtheria toxin receptor, DTR, HBEGF, DTS, DT-R, DTSF, Heparin-binding EGF-like growth factor precursor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:6.88

cerebellum:6.90

brain stem:6.97

corpus callosum/glia:7.63

pineal gland:-

peripheral nerve:7.49

spine:7.73

retina:-

eye:-

artery/aorta:7.80

vein:7.93

lymphnode:6.76

peripheral blood:-

spleen:6.66

thymus:6.49

bone marrow:6.35

adipose:7.56

bone:-

skin:7.56

CAGE

cerebrum:2.27

cerebellum:-

brain stem:2.53

corpus callosum/glia:3.01

pineal gland:2.17

peripheral nerve:-

spine:2.79

retina:-

eye:-

artery/aorta:3.69

vein:3.14

lymphnode:2.30

peripheral blood:-

spleen:1.71

thymus:0.99

bone marrow:-

adipose:3.15

bone:-

skin:-

RNA-seq

cerebrum:3.35

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.10

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:5.47

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:4.90

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.81

placenta:6.35

prostate:7.47

ovary:6.30

testis:6.47

heart:8.12

muscle:7.79

esophagus:7.97

stomach:7.30

intestine:6.92

colon:6.69

liver/hepato:6.27

lung:9.39

bladder:-

kidney:6.71

pituitary:6.81

thyroid/parathyroid:6.85

adrenal gland:6.78

pancreas:6.79

breast:6.96

salivary:6.43

CAGE

uterus:2.63

placenta:1.90

prostate:2.50

ovary:2.38

testis:2.43

heart:3.58

muscle:2.44

esophagus:3.63

stomach:-

intestine:2.41

colon:2.26

liver/hepato:1.47

lung:4.07

bladder:3.31

kidney:1.55

pituitary:1.69

thyroid/parathyroid:2.29

adrenal gland:-

pancreas:1.87

breast:3.49

salivary:1.82

RNA-seq

uterus:-

placenta:-

prostate:3.75

ovary:2.08

testis:3.00

heart:3.10

muscle:4.07

esophagus:-

stomach:-

intestine:-

colon:4.30

liver/hepato:0.63

lung:6.50

bladder:-

kidney:1.96

pituitary:-

thyroid/parathyroid:3.23

adrenal gland:2.13

pancreas:-

breast:2.68

salivary:-

IDs

Refseq ID	NM_001945
Gene ID	1839
Unigene ID	Hs.592942
Probe set ID	203821_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000113070
GTEx ID	ENSG00000113070

Orthologous Gene

Mouse[2]	NM_010415
Rat [0]

Chromosomal Region

5q31.3 [139,712,428 - 139,726,216]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000742

EGF-like, type 3

Gene Ontology (GO ID)

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0045087	innate immune response
GO:0007517	muscle organ development
GO:0051545	negative regulation of elastin biosynthetic process
GO:0048011	nerve growth factor receptor signaling pathway
GO:0048015	phosphoinositide-mediated signaling
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0051549	positive regulation of keratinocyte migration
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0008016	regulation of heart contraction
GO:0007165	signal transduction
GO:0035313	wound healing, spreading of epidermal cells

Cellular Component

GO:0009986	cell surface
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005887	integral to plasma membrane

Molecular Function

GO:0005154	epidermal growth factor receptor binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

heparin-binding EGF-like growth factor

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function