dual specificity phosphatase 1

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Synonym

HVH1, MKP1, Dual specificity protein phosphatase hVH1, MKP-1, MAP kinase phosphatase 1, dual specificity phosphatase 1, VH1, Protein-tyrosine phosphatase CL100, PTPN10, Dual specificity protein phosphatase 1, CL100, DUSP1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:54.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:445 peripheral nerve:184 spine:673.80 retina:- eye:452.50 artery/aorta:89.90 vein:- lymphnode:212.30 peripheral blood:164 spleen:75.60 thymus:38.70 bone marrow:137.80 adipose:645.30 bone:127.90 skin:163.20
GeneChip cerebrum:8.86 cerebellum:9.80 brain stem:8.90 corpus callosum/glia:10.02 pineal gland:- peripheral nerve:10.91 spine:10.95 retina:- eye:- artery/aorta:11.66 vein:12.34 lymphnode:10.78 peripheral blood:- spleen:11.26 thymus:9.87 bone marrow:11.07 adipose:11.88 bone:- skin:11.76
CAGE cerebrum:4.52 cerebellum:- brain stem:5.22 corpus callosum/glia:5.57 pineal gland:4.44 peripheral nerve:- spine:5.57 retina:- eye:- artery/aorta:7.68 vein:6.39 lymphnode:5.90 peripheral blood:- spleen:5.49 thymus:4.27 bone marrow:- adipose:7.16 bone:- skin:-
RNA-seq cerebrum:4.68 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:7.69 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:8.15 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:191.40 placenta:309.70 prostate:360.50 ovary:260.80 testis:90.90 heart:89.40 muscle:20.10 esophagus:- stomach:106.20 intestine:97.20 colon:101.80     liver/hepato:105.60        lung:215.10    bladder:- kidney:228.70 pituitary:463.90 thyroid/parathyroid:163.70 adrenal gland:203.10 pancreas:391.20 breast:185.90 salivary:-
GeneChip uterus:11.17 placenta:10.98 prostate:11.88 ovary:11.24 testis:9.36 heart:11.36 muscle:9.89 esophagus:11.63 stomach:11.09 intestine:10.30 colon:10.32 liver/hepato:10.78 lung:12.41 bladder:- kidney:11.14 pituitary:10.94 thyroid/parathyroid:11.67 adrenal gland:11.67 pancreas:10.34 breast:11.54 salivary:10.75
CAGE uterus:6.34 placenta:6.52 prostate:6.34 ovary:6.30 testis:5.61 heart:6.06 muscle:6.06 esophagus:6.48 stomach:- intestine:5.36 colon:5.23     liver/hepato:6.64    lung:7.28 bladder:6.31 kidney:5.15 pituitary:5.62 thyroid/parathyroid:6.13 adrenal gland:- pancreas:4.28 breast:6.67 salivary:5.72
RNA-seq uterus:- placenta:- prostate:7.82 ovary:5.76 testis:6.98 heart:5.17 muscle:6.57 esophagus:- stomach:- intestine:- colon:6.68     liver/hepato:6.12        lung:9.04    bladder:- kidney:6.43 pituitary:- thyroid/parathyroid:8.07 adrenal gland:6.96 pancreas:- breast:7.76 salivary:-

Gene Information

IDs

Refseq ID NM_004417
Gene ID 1843
Unigene ID Hs.171695
Probe set ID 201041_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000120129
GTEx ID ENSG00000120129

Orthologous Gene

Mouse[1]  NM_013642
Rat [0]  

Chromosomal Region

5q35.1  [172,195,093  -  172,198,198]

Gene Family (Interpro ID)

IPR020417  Dual specificity phosphatase
IPR000340  Dual specificity phosphatase, catalytic domain
IPR020420  Dual specificity phosphatase, subfamily B
IPR020422  Dual specificity phosphatase, subgroup, catalytic domain
IPR014393  Dual specificity protein phosphatase (MAP kinase phosphatase)
IPR008343  MAP kinase phosphatase

Link to Pubmed  (Pubmed ID)

1406996
7535770
7593328
7806236
8106404
8168826
8221888
8389479
8390041
9571625
9599409
10022904
10617468
11062068
11278799
11359773
12080474
12356755
12391149
12432554
12477932
12506119
12676937
12765304
12890671
12947325
12960255
14551204
14680833
14702039
14724291
15059515
15173070
15247770
15339908
15448190
15489334
15569826
15590693
15614136
15677475
16044158
16081065
16224818
16286470
16289033
16293973
16387640
16951204
17073741
17131384
17489738
17560945
17638884
17681939
17690186
17761948
17848570
18003751
18089824
18095520
18178562
18314542
18367666
18403641
18434324
18441094
18477563
18490444
18519678
18723442
18726921
18782768
19020052
19032224
19117950
19262425
19411256
19417026
19553005
19604093
19648110
19697705
19724859
19755862
19793766
19797979
19913121
19940143
20043958
20089808
20100830
20145951
20228065
20353815
20375469
20555314
20628086
20673984
20689807
20708668
20803086
20805296
20829434
20868379
20890299
20936779
20953200
21060794
21454676
21507959
21547253
21610072
21715333
21733716
21803700
21840882
21906983
21959016
21960346
21963094
21987572
21988832
22014408
22020934
22200679
22301548
22505724
22610099
22743041
22797925
22924482
22991462
23030431
23097457
23149933
23169297
23333304
23625220
23728617
23825193
24086554
24155659
24308939
24578378
24692548

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0032870  cellular response to hormone stimulus
GO:0001706  endoderm formation
GO:0000188  inactivation of MAPK activity
GO:0043065  positive regulation of apoptosis
GO:0006470  protein amino acid dephosphorylation
GO:0042981  regulation of apoptosis
GO:0051592  response to calcium ion
GO:0051591  response to cAMP
GO:0032355  response to estradiol stimulus
GO:0051384  response to glucocorticoid stimulus
GO:0042542  response to hydrogen peroxide
GO:0009416  response to light stimulus
GO:0006979  response to oxidative stress
GO:0032526  response to retinoic acid
GO:0033574  response to testosterone stimulus

Cellular Component

GO:0005654  nucleoplasm

Molecular Function

GO:0017017  MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0004726  non-membrane spanning protein tyrosine phosphatase activity
GO:0005515  protein binding
GO:0008330  protein tyrosine/threonine phosphatase activity