dual specificity phosphatase 3

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Synonym

Dual specificity protein phosphatase VHR, Dual specificity protein phosphatase 3, VHR, DUSP3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:229.90 cerebellum:176.30 brain stem:- corpus callosum/glia:145.80 pineal gland:148.30 peripheral nerve:92 spine:112.30 retina:118.60 eye:141 artery/aorta:60 vein:133.30 lymphnode:- peripheral blood:109.30 spleen:56.70 thymus:51.50 bone marrow:- adipose:40.30 bone:102.40 skin:182.40
GeneChip cerebrum:8.76 cerebellum:8.48 brain stem:8.62 corpus callosum/glia:8.10 pineal gland:- peripheral nerve:8.97 spine:8.07 retina:- eye:- artery/aorta:9.10 vein:9.21 lymphnode:7.62 peripheral blood:- spleen:8.50 thymus:6.31 bone marrow:7.22 adipose:8.22 bone:- skin:8.06
CAGE cerebrum:4.37 cerebellum:- brain stem:4.25 corpus callosum/glia:3.97 pineal gland:4.23 peripheral nerve:- spine:4.21 retina:- eye:- artery/aorta:4.99 vein:4.02 lymphnode:3.60 peripheral blood:- spleen:4.20 thymus:2.04 bone marrow:- adipose:4.38 bone:- skin:-
RNA-seq cerebrum:4.44 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.28 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.57 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:355.40 placenta:87.40 prostate:56.30 ovary:111.80 testis:125.50 heart:127.70 muscle:20.10 esophagus:- stomach:63.70 intestine:97.20 colon:25.40     liver/hepato:84.40        lung:307.90    bladder:125.60 kidney:83.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:168.90 breast:92.90 salivary:-
GeneChip uterus:8.31 placenta:8.31 prostate:8.45 ovary:7.94 testis:7.85 heart:9.49 muscle:10.11 esophagus:8.65 stomach:8.70 intestine:8.60 colon:8.34 liver/hepato:9.46 lung:8.55 bladder:- kidney:9.17 pituitary:8.12 thyroid/parathyroid:8.17 adrenal gland:8.49 pancreas:8 breast:8.39 salivary:7.84
CAGE uterus:4.13 placenta:4.15 prostate:4.20 ovary:3.75 testis:3.63 heart:5.22 muscle:5.34 esophagus:4.55 stomach:- intestine:4.23 colon:4.44     liver/hepato:4.95    lung:4.20 bladder:4.54 kidney:4.61 pituitary:3.90 thyroid/parathyroid:3.96 adrenal gland:- pancreas:4.44 breast:4.68 salivary:3.58
RNA-seq uterus:- placenta:- prostate:5.05 ovary:3.93 testis:4.50 heart:6.00 muscle:6.03 esophagus:- stomach:- intestine:- colon:4.96     liver/hepato:5.10        lung:4.71    bladder:- kidney:5.28 pituitary:- thyroid/parathyroid:4.99 adrenal gland:4.73 pancreas:- breast:4.87 salivary:-

Gene Information

IDs

Refseq ID NM_004090
Gene ID 1845
Unigene ID Hs.181046
Probe set ID 201536_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000108861
GTEx ID ENSG00000108861

Orthologous Gene

Mouse[4]  NM_028207
Rat [0]  

Chromosomal Region

17q21.31  [41,843,490  -  41,856,368]

Gene Family (Interpro ID)

IPR020417  Dual specificity phosphatase
IPR000340  Dual specificity phosphatase, catalytic domain
IPR020405  Dual specificity phosphatase, subfamily A
IPR020422  Dual specificity phosphatase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1281549
7829067
7829094
7874108
7876121
7961745
8650541
10224087
11085983
11238845
11863439
12447358
12477932
12840032
14702039
15276183
15489334
16344560
16604064
17278098
17322878
17785772
18311544
18505570
19010898
19322201
21262974
21832049
21890473
21906983
21921027
21988832
22053931
23000965
23322772
23918168
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0000188  inactivation of MAPK activity
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0046329  negative regulation of JNK cascade
GO:0043409  negative regulation of MAPKKK cascade
GO:0050868  negative regulation of T cell activation
GO:0050860  negative regulation of T cell receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0045931  positive regulation of mitotic cell cycle
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0001772  immunological synapse
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0033549  MAP kinase phosphatase activity
GO:0004725  protein tyrosine phosphatase activity
GO:0008138  protein tyrosine/serine/threonine phosphatase activity