dishevelled, dsh homolog 1 (Drosophila)

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Synonym

Dishevelled-1, dishevelled, dsh homolog 1 (Drosophila), DSH homolog 1, DVL, Segment polarity protein dishevelled homolog DVL-1, DVL1, dishevelled 1 (homologous to Drosophila dsh), MGC54245

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.21 cerebellum:7.24 brain stem:6.85 corpus callosum/glia:7.14 pineal gland:- peripheral nerve:6.94 spine:6.72 retina:- eye:- artery/aorta:7.10 vein:6.44 lymphnode:6.69 peripheral blood:- spleen:6.64 thymus:6.28 bone marrow:5.65 adipose:6.68 bone:- skin:7.02
CAGE cerebrum:3.15 cerebellum:- brain stem:2.95 corpus callosum/glia:3.17 pineal gland:2.83 peripheral nerve:- spine:2.92 retina:- eye:- artery/aorta:3.09 vein:2.25 lymphnode:2.17 peripheral blood:- spleen:2.13 thymus:1.56 bone marrow:- adipose:2.50 bone:- skin:-
RNA-seq cerebrum:2.97 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.42 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.63 placenta:6.94 prostate:6.73 ovary:6.77 testis:7.56 heart:7.03 muscle:8.06 esophagus:7.66 stomach:7.16 intestine:7.19 colon:6.58 liver/hepato:7.42 lung:6.94 bladder:- kidney:7.05 pituitary:6.59 thyroid/parathyroid:7.03 adrenal gland:7.47 pancreas:7.18 breast:7.15 salivary:7.94
CAGE uterus:2.61 placenta:2.78 prostate:2.71 ovary:2.43 testis:2.98 heart:3.16 muscle:3.76 esophagus:2.93 stomach:- intestine:2.86 colon:3.15     liver/hepato:2.52    lung:2.74 bladder:2.83 kidney:2.35 pituitary:2.14 thyroid/parathyroid:2.70 adrenal gland:- pancreas:3.57 breast:3.09 salivary:3.03
RNA-seq uterus:- placenta:- prostate:3.71 ovary:3.52 testis:3.77 heart:3.54 muscle:5.43 esophagus:- stomach:- intestine:- colon:3.97     liver/hepato:2.61        lung:3.22    bladder:- kidney:2.82 pituitary:- thyroid/parathyroid:3.92 adrenal gland:2.70 pancreas:- breast:3.56 salivary:-

Gene Information

IDs

Refseq ID NM_004421
Gene ID 1855
Unigene ID -
Probe set ID 203230_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000107404
GTEx ID ENSG00000107404

Orthologous Gene

Mouse[2]  NM_010091
Rat[1]  NM_031820

Chromosomal Region

1p36.33  [1,270,656  -  1,284,760]

Gene Family (Interpro ID)

IPR000591  DEP domain
IPR015506  Dishevelled related protein
IPR008340  Dishevelled-1 protein
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

8288125
8644734
8817329
8856345
9192851
9344861
9482734
10330181
10330403
10332026
10428961
10581192
10644691
10806215
11113207
11487578
11742073
11779461
11803455
11818547
12477932
12490194
12533515
12556519
12650946
12805222
12824876
12883684
12941796
14684739
14702039
14747478
14750955
15262978
15342556
15454084
15456783
15852005
16169070
16457155
16621789
17593335
18093802
18162551
18223681
18347071
18632848
18692936
18760999
18976975
19388021
19453261
19465938
19561074
19625296
19643732
19956716
20177058
20227366
20388731
20412773
20439735
20634891
20639201
20846493
21044957
21262972
21900206
21906983
21963094
21988832
22467858
22826439
23836490
24040443
24129181
24500924
24550385
24643799

Gene Ontology  (GO ID)

Biological Process

GO:0048675  axon extension
GO:0007411  axon guidance
GO:0090103  cochlea morphogenesis
GO:0048668  collateral sprouting
GO:0060026  convergent extension
GO:0022007  convergent extension involved in neural plate elongation
GO:0031122  cytoplasmic microtubule organization
GO:0048813  dendrite morphogenesis
GO:0007507  heart development
GO:0032091  negative regulation of protein binding
GO:0006469  negative regulation of protein kinase activity
GO:0021915  neural tube development
GO:0007528  neuromuscular junction development
GO:0007269  neurotransmitter secretion
GO:0090179  planar cell polarity pathway involved in neural tube closure
GO:0010976  positive regulation of neuron projection development
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0060134  prepulse inhibition
GO:0034504  protein localization in nucleus
GO:0043113  receptor clustering
GO:0001505  regulation of neurotransmitter levels
GO:0007165  signal transduction
GO:0071340  skeletal muscle nicotinic acetylcholine receptor clustering
GO:0035176  social behavior
GO:0050808  synapse organization
GO:0006366  transcription from RNA polymerase II promoter
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0030424  axon
GO:0005938  cell cortex
GO:0043025  cell soma
GO:0030136  clathrin-coated vesicle
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0030425  dendrite
GO:0030426  growth cone
GO:0016328  lateral plasma membrane
GO:0005874  microtubule
GO:0045202  synapse

Molecular Function

GO:0019899  enzyme binding
GO:0005109  frizzled binding
GO:0042802  identical protein binding
GO:0003674  molecular_function
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0048365  Rac GTPase binding
GO:0004871  signal transducer activity