dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

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Synonym

Dual specificity YAK1-related kinase, DYRK1A, MNBH, DYRK1, HP86, MNB, Protein kinase minibrain homolog, DYRK

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:101.90

cerebellum:37.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:276

spine:112.30

retina:-

eye:52.90

artery/aorta:30

vein:66.60

lymphnode:80.90

peripheral blood:91.10

spleen:94.50

thymus:154.60

bone marrow:236.20

adipose:-

bone:38.40

skin:163.20

GeneChip

cerebrum:7.65

cerebellum:8.05

brain stem:7.51

corpus callosum/glia:7.43

pineal gland:-

peripheral nerve:7.68

spine:7.47

retina:-

eye:-

artery/aorta:7.56

vein:7.86

lymphnode:7.90

peripheral blood:-

spleen:8.31

thymus:9.08

bone marrow:8

adipose:7.58

bone:-

skin:7.86

CAGE

cerebrum:3.57

cerebellum:-

brain stem:3.32

corpus callosum/glia:3.47

pineal gland:3.53

peripheral nerve:-

spine:3.38

retina:-

eye:-

artery/aorta:3.59

vein:3.95

lymphnode:3.77

peripheral blood:-

spleen:3.63

thymus:4.58

bone marrow:-

adipose:3.65

bone:-

skin:-

RNA-seq

cerebrum:4.34

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.93

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.18

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:72.90

placenta:138.40

prostate:67.60

ovary:37.30

testis:56.20

heart:89.40

muscle:20.10

esophagus:-

stomach:169.90

intestine:32.40

colon:84.80

liver/hepato:63.30

lung:92.90

bladder:-

kidney:104

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:44.50

breast:176.60

salivary:-

GeneChip

uterus:8.31

placenta:8.50

prostate:8.19

ovary:8.42

testis:8.30

heart:7.71

muscle:8.55

esophagus:7.46

stomach:7.41

intestine:7.47

colon:6.88

liver/hepato:6.80

lung:7.89

bladder:-

kidney:7.24

pituitary:7.58

thyroid/parathyroid:8.17

adrenal gland:7.53

pancreas:5.84

breast:8.04

salivary:7.32

CAGE

uterus:3.73

placenta:3.61

prostate:3.51

ovary:3.85

testis:3.80

heart:3.45

muscle:3.78

esophagus:3.39

stomach:-

intestine:3.50

colon:3.52

liver/hepato:3.27

lung:3.94

bladder:3.77

kidney:3.06

pituitary:3.69

thyroid/parathyroid:3.44

adrenal gland:-

pancreas:3.20

breast:3.67

salivary:3.50

RNA-seq

uterus:-

placenta:-

prostate:4.23

ovary:4.76

testis:5.32

heart:3.92

muscle:5.04

esophagus:-

stomach:-

intestine:-

colon:3.80

liver/hepato:2.35

lung:3.76

bladder:-

kidney:3.28

pituitary:-

thyroid/parathyroid:4.70

adrenal gland:4.40

pancreas:-

breast:4.08

salivary:-

IDs

Refseq ID	NM_001396
Gene ID	1859
Unigene ID	Hs.368240
Probe set ID	209033_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000157540
GTEx ID	ENSG00000157540

Orthologous Gene

Mouse[6]	NM_001113389, NM_007890
Rat [0]

Chromosomal Region

21q22.13 [38,739,236 - 38,887,680]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0007623	circadian rhythm
GO:0000278	mitotic cell cycle
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0007399	nervous system development
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation

Cellular Component

GO:0016607	nuclear speck
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0030529	ribonucleoprotein complex

Molecular Function

GO:0005524	ATP binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0043621	protein self-association
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0048156	tau protein binding

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function