epithelial cell transforming sequence 2 oncogene

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Synonym

ECT2, FLJ10461, Epithelial cell-transforming sequence 2 oncogene, epithelial cell transforming sequence 2 oncogene, ECT2 protein, MGC138291

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:30.80 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:50.60 peripheral blood:- spleen:- thymus:90.20 bone marrow:- adipose:- bone:12.80 skin:28.80
GeneChip cerebrum:2.98 cerebellum:2.79 brain stem:3.15 corpus callosum/glia:2.80 pineal gland:- peripheral nerve:3.11 spine:3.05 retina:- eye:- artery/aorta:2.96 vein:2.87 lymphnode:3.53 peripheral blood:- spleen:3.01 thymus:6.41 bone marrow:4.90 adipose:3.09 bone:- skin:3.37
CAGE cerebrum:2.05 cerebellum:- brain stem:2.43 corpus callosum/glia:1.44 pineal gland:1.97 peripheral nerve:- spine:2.41 retina:- eye:- artery/aorta:1.48 vein:2.11 lymphnode:1.84 peripheral blood:- spleen:2.46 thymus:3.96 bone marrow:- adipose:2.25 bone:- skin:-
RNA-seq cerebrum:1.83 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.06 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.57 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:10.90 prostate:11.30 ovary:- testis:129.80 heart:25.50 muscle:- esophagus:- stomach:- intestine:32.40 colon:127.20     liver/hepato:10.60        lung:53.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:92.90 salivary:-
GeneChip uterus:3.69 placenta:3.28 prostate:3.23 ovary:3.24 testis:5.34 heart:2.81 muscle:2.72 esophagus:3.71 stomach:4.02 intestine:3.74 colon:3.46 liver/hepato:2.73 lung:3.12 bladder:- kidney:2.94 pituitary:2.86 thyroid/parathyroid:3.10 adrenal gland:2.94 pancreas:2.59 breast:3.69 salivary:3.04
CAGE uterus:1.92 placenta:2.60 prostate:1.74 ovary:1.61 testis:3.04 heart:1.87 muscle:0.59 esophagus:2.65 stomach:- intestine:2.31 colon:2.25     liver/hepato:1.71    lung:2.49 bladder:1.76 kidney:2.54 pituitary:1.95 thyroid/parathyroid:2.02 adrenal gland:- pancreas:1.21 breast:2.34 salivary:1.15
RNA-seq uterus:- placenta:- prostate:1.39 ovary:1.27 testis:3.19 heart:1.51 muscle:0.27 esophagus:- stomach:- intestine:- colon:1.86     liver/hepato:0.64        lung:2.16    bladder:- kidney:2.19 pituitary:- thyroid/parathyroid:1.33 adrenal gland:1.45 pancreas:- breast:2.02 salivary:-

Gene Information

IDs

Refseq ID NM_018098
Gene ID 1894
Unigene ID Hs.518299
Probe set ID 219787_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000114346
GTEx ID ENSG00000114346

Orthologous Gene

Mouse[1]  NM_001177625, NM_001177626, NM_007900
Rat[1]  NM_001177625, NM_001177626, NM_007900

Chromosomal Region

3q26.31  [172,468,472  -  172,539,264]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7665179
8464478
8889549
10579713
10837491
11756498
12376548
12376551
12477932
12761501
12787561
14587037
14668487
14702039
15254234
15545273
15642749
16103226
16118207
16129829
16170345
16236794
16247472
16344560
16352658
16778203
16803869
16862181
16964243
17115030
17395875
17474147
17488623
17688947
17942602
18201571
18511905
18642445
18842503
19008376
19015243
19118053
19468300
19468302
19617897
20360068
20734064
21124766
21139048
21189248
21373644
21474972
21886810
21906983
21963094
22172673
22514687
22552385
22683310
22898780
22990118
23251661
23601845
23851435
24198276
24484057

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0032863  activation of Rac GTPase activity
GO:0032862  activation of Rho GTPase activity
GO:0000902  cell morphogenesis
GO:0071277  cellular response to calcium ion
GO:0070301  cellular response to hydrogen peroxide
GO:0071479  cellular response to ionizing radiation
GO:0000910  cytokinesis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0043089  positive regulation of Cdc42 GTPase activity
GO:0032467  positive regulation of cytokinesis
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045666  positive regulation of neuron differentiation
GO:0042307  positive regulation of protein import into nucleus
GO:0032321  positive regulation of Rho GTPase activity
GO:0051260  protein homooligomerization
GO:0015031  protein transport
GO:0051988  regulation of attachment of spindle microtubules to kinetochore
GO:0045859  regulation of protein kinase activity
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0070830  tight junction assembly

Cellular Component

GO:0005911  cell-cell junction
GO:0032154  cleavage furrow
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030496  midbody
GO:0005634  nucleus
GO:0005923  tight junction

Molecular Function

GO:0005096  GTPase activator activity
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0017048  Rho GTPase binding
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0004871  signal transducer activity