endothelin receptor type A

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Synonym

hET-AR, EDNRA, Endothelin-1 receptor precursor, ETRA, endothelin receptor type A, ETA, ET-A, Endothelin A receptor, ETA-R

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:33.20 cerebellum:37.80 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:92 spine:112.30 retina:- eye:41.10 artery/aorta:89.90 vein:- lymphnode:- peripheral blood:- spleen:132.30 thymus:38.70 bone marrow:- adipose:80.70 bone:51.20 skin:33.60
GeneChip cerebrum:3.46 cerebellum:3.14 brain stem:3.56 corpus callosum/glia:3.29 pineal gland:- peripheral nerve:5.46 spine:3.46 retina:- eye:- artery/aorta:5.41 vein:6.73 lymphnode:4.48 peripheral blood:- spleen:5.57 thymus:4.28 bone marrow:3.24 adipose:5.20 bone:- skin:4.26
CAGE cerebrum:1.56 cerebellum:- brain stem:1.82 corpus callosum/glia:1.49 pineal gland:1.65 peripheral nerve:- spine:1.84 retina:- eye:- artery/aorta:3.14 vein:2.87 lymphnode:2.01 peripheral blood:- spleen:3.38 thymus:2.00 bone marrow:- adipose:2.93 bone:- skin:-
RNA-seq cerebrum:0.37 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.44 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:419.20 placenta:65.60 prostate:112.60 ovary:37.30 testis:77.90 heart:102.20 muscle:- esophagus:- stomach:42.50 intestine:- colon:8.50     liver/hepato:21.10        lung:102.60    bladder:125.60 kidney:- pituitary:347.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:65.10 salivary:-
GeneChip uterus:8.60 placenta:4.60 prostate:7.62 ovary:6.87 testis:4.68 heart:6.29 muscle:3.75 esophagus:4.17 stomach:5.06 intestine:4.68 colon:4.04 liver/hepato:3.69 lung:7.36 bladder:- kidney:4.05 pituitary:3.59 thyroid/parathyroid:4.58 adrenal gland:4.93 pancreas:3.42 breast:5.81 salivary:3.83
CAGE uterus:4.86 placenta:2.69 prostate:4.07 ovary:4.09 testis:3.09 heart:3.35 muscle:2.40 esophagus:2.60 stomach:- intestine:1.81 colon:2.10     liver/hepato:1.25    lung:3.63 bladder:3.63 kidney:2.06 pituitary:1.53 thyroid/parathyroid:2.24 adrenal gland:- pancreas:0 breast:3.02 salivary:2.06
RNA-seq uterus:- placenta:- prostate:3.20 ovary:3.51 testis:2.79 heart:2.03 muscle:1.03 esophagus:- stomach:- intestine:- colon:1.26     liver/hepato:0.37        lung:3.24    bladder:- kidney:0.92 pituitary:- thyroid/parathyroid:1.64 adrenal gland:2.22 pancreas:- breast:1.98 salivary:-

Gene Information

IDs

Refseq ID NM_001957
Gene ID 1909
Unigene ID Hs.183713
Probe set ID 204463_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000151617
GTEx ID ENSG00000151617

Orthologous Gene

Mouse[4]  NM_010332
Rat[2]  NM_012550

Chromosomal Region

4q31.22  [148,402,069  -  148,466,106]

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR002175  Endothelin A receptor
IPR000499  Endothelin receptor
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

1291713
1326535
1415318
1652463
1659806
1719979
1849646
7509919
7882989
8114678
8427579
8440682
8611157
8702836
8982507
9211925
9284755
9645692
10448102
10770212
10789830
11262386
11376172
11382773
11601839
11930911
11982704
12082592
12477932
12544508
12595285
12629276
12768436
12875994
14519635
14616768
14636059
14729387
15041798
15047866
15073116
15139053
15187089
15213100
15489334
15713850
15838262
15838285
15838315
15838329
15838364
15838366
15838367
15851553
15988412
16002759
16149067
16208144
16344560
16531800
16567585
16582543
16618267
16648553
16754659
16816835
16879994
16947775
16962346
16971893
16984730
17016617
17122448
17198909
17203161
17353514
17437213
17468950
17470272
17525706
17575543
17616673
17616694
17706018
18172451
18187620
18212505
18326801
18577758
18660489
18678984
18756291
18945538
19202075
19217622
19225824
19247692
19367425
19460784
19479828
19558538
19575782
19578796
19593212
19601701
19626996
19653178
19898645
19913121
20028935
20034471
20043107
20083432
20100616
20150570
20346360
20371740
20401344
20485444
20538960
20628086
20725140
20963824
20964792
21057729
21220476
21356562
21418087
21424380
21453125
21487064
21498912
21515378
21601190
21773759
21909108
22106312
22129540
22286173
22365955
22480520
22510270
22561246
22580289
22688668
22997346
23058564
23064961
23217151
23233754
23251661
23436727
23515723
23683481
23754170
23818293
23987636
24064210
24262325
24627317

Gene Ontology  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0007202  activation of phospholipase C activity
GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0007568  aging
GO:0014824  artery smooth muscle contraction
GO:0008283  cell proliferation
GO:0071260  cellular response to mechanical stimulus
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0051482  elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
GO:0048484  enteric nervous system development
GO:0048144  fibroblast proliferation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0003094  glomerular filtration
GO:0015758  glucose transport
GO:0060322  head development
GO:0007507  heart development
GO:0001821  histamine secretion
GO:0001701  in utero embryonic development
GO:0060137  maternal process involved in parturition
GO:0043066  negative regulation of apoptosis
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0014032  neural crest cell development
GO:0001569  patterning of blood vessels
GO:0043084  penile erection
GO:0008284  positive regulation of cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0050729  positive regulation of inflammatory response
GO:0090184  positive regulation of kidney development
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0042482  positive regulation of odontogenesis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0008217  regulation of blood pressure
GO:0050678  regulation of epithelial cell proliferation
GO:0007585  respiratory gaseous exchange
GO:0001666  response to hypoxia
GO:0032496  response to lipopolysaccharide
GO:0043278  response to morphine
GO:0007266  Rho protein signal transduction
GO:0019233  sensory perception of pain
GO:0007165  signal transduction
GO:0048659  smooth muscle cell proliferation
GO:0006939  smooth muscle contraction
GO:0042310  vasoconstriction

Cellular Component

GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0031965  nuclear membrane
GO:0005886  plasma membrane
GO:0030315  T-tubule

Molecular Function

GO:0004962  endothelin receptor activity
GO:0004435  phosphoinositide phospholipase C activity
GO:0005515  protein binding