EPH receptor A2

Synonym

EphA2, EPHA2, Ephrin type-A receptor 2 precursor, ECK, EPH receptor A2, Tyrosine-protein kinase receptor ECK, Epithelial cell kinase

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:3.60

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:41.10

artery/aorta:-

vein:66.60

lymphnode:10.10

peripheral blood:-

spleen:18.90

thymus:12.90

bone marrow:-

adipose:-

bone:-

skin:67.20

GeneChip

cerebrum:4.57

cerebellum:4.82

brain stem:4.56

corpus callosum/glia:4.53

pineal gland:-

peripheral nerve:5.28

spine:4.65

retina:-

eye:-

artery/aorta:5.37

vein:5.76

lymphnode:6.22

peripheral blood:-

spleen:5.48

thymus:4.65

bone marrow:4.59

adipose:6.11

bone:-

skin:6.78

CAGE

cerebrum:0.95

cerebellum:-

brain stem:1.15

corpus callosum/glia:1.04

pineal gland:1.89

peripheral nerve:-

spine:1.70

retina:-

eye:-

artery/aorta:2.30

vein:2.35

lymphnode:2.68

peripheral blood:-

spleen:1.36

thymus:0.64

bone marrow:-

adipose:2.08

bone:-

skin:-

RNA-seq

cerebrum:1.22

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.12

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.91

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:29.10

prostate:-

ovary:-

testis:4.30

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:67.80

liver/hepato:31.70

lung:34.20

bladder:-

kidney:93.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:115.60

breast:46.50

salivary:328.40

GeneChip

uterus:5.87

placenta:5.18

prostate:5.03

ovary:5.38

testis:4.55

heart:5.81

muscle:4.91

esophagus:8.54

stomach:5.58

intestine:5.46

colon:5.58

liver/hepato:5.46

lung:6.50

bladder:-

kidney:5.53

pituitary:4.81

thyroid/parathyroid:5.57

adrenal gland:5.74

pancreas:5.69

breast:6.02

salivary:8.21

CAGE

uterus:2.56

placenta:2.37

prostate:2.17

ovary:1.93

testis:1.02

heart:2.04

muscle:1.46

esophagus:4.13

stomach:-

intestine:2.79

colon:2.09

liver/hepato:1.95

lung:1.87

bladder:2.75

kidney:1.91

pituitary:0.90

thyroid/parathyroid:1.87

adrenal gland:-

pancreas:1.87

breast:1.80

salivary:3.80

RNA-seq

uterus:-

placenta:-

prostate:2.34

ovary:2.35

testis:1.96

heart:1.51

muscle:1.25

esophagus:-

stomach:-

intestine:-

colon:1.94

liver/hepato:1.01

lung:3.86

bladder:-

kidney:1.75

pituitary:-

thyroid/parathyroid:2.23

adrenal gland:3.68

pancreas:-

breast:2.48

salivary:-

IDs

Refseq ID	NM_004431
Gene ID	1969
Unigene ID	Hs.171596
Probe set ID	203499_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000142627
GTEx ID	ENSG00000142627

Orthologous Gene

Mouse[1]	NM_010139
Rat[1]	NM_001108977

Chromosomal Region

1p36.13 [16,450,832 - 16,482,582]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0032863	activation of Rac GTPase activity
GO:0001525	angiogenesis
GO:0048320	axial mesoderm formation
GO:0046849	bone remodeling
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0007155	cell adhesion
GO:0060326	cell chemotaxis
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0048013	ephrin receptor signaling pathway
GO:0030216	keratinocyte differentiation
GO:0070309	lens fiber cell morphogenesis
GO:0033598	mammary gland epithelial cell proliferation
GO:0007275	multicellular organismal development
GO:0051898	negative regulation of protein kinase B signaling cascade
GO:0021915	neural tube development
GO:0030182	neuron differentiation
GO:0060035	notochord cell development
GO:0014028	notochord formation
GO:0001649	osteoblast differentiation
GO:0030316	osteoclast differentiation
GO:0090004	positive regulation of establishment of protein localization in plasma membrane
GO:0043491	protein kinase B signaling cascade
GO:0045765	regulation of angiogenesis
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0010591	regulation of lamellipodium assembly
GO:0070848	response to growth factor stimulus
GO:0001501	skeletal system development
GO:0001570	vasculogenesis

Cellular Component

GO:0005925	focal adhesion
GO:0005887	integral to plasma membrane
GO:0031258	lamellipodium membrane
GO:0031256	leading edge membrane
GO:0005886	plasma membrane
GO:0032587	ruffle membrane

Molecular Function

GO:0005524	ATP binding
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0004714	transmembrane receptor protein tyrosine kinase activity

IPR001090	Ephrin receptor, ligand binding
IPR003961	Fibronectin, type III
IPR008957	Fibronectin, type III-like fold
IPR008979	Galactose-binding domain-like
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001660	Sterile alpha motif
IPR010993	Sterile alpha motif homology
IPR013761	Sterile alpha motif-type
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR016257	Tyrosine-protein kinase, ephrin receptor
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

EPH receptor A2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function